Isoxazoline compositions and use thereof in the prevention or treatment of parasite infestations in animals

Patent metadata

Field	Value
Publication number	US-11883530-B2
Application number	US-202117390296-A
Country	US
Kind code	B2
Filing date	Jul 30, 2021
Priority date	Dec 20, 2013
Publication date	Jan 30, 2024
Grant date	Jan 30, 2024

Abstract

This invention is directed to a pharmaceutical composition for drinking water administration comprising isoxazoline compounds of formula (I) and a polysorbate surfactant and diethylene glycol monoethyl ether (transcutol); and the use of the composition to treat or prevent parasite infestations of animals.

First claim

The invention claimed is:

1. A method of preventing or treating parasite infestations in animals by administering to such animal in its drinking water a pharmaceutical composition comprising fluralaner or a salt or solvate thereof, and a pharmaceutically acceptable carrier comprising diethylene glycol monoethyl ether and a polysorbate surfactant, wherein the polysorbate is 30 to 80% by weight of the pharmaceutical composition.

2. The method according to claim 1 comprising between 1.5 mg/ml and 100 mg/ml of fluralaner.

3. The method according to claim 1 wherein the ratio of diethylene glycol monoethyl ether to polysorbate surfactant is <about 25/75 w/w.

4. The method according to claim 1 wherein the animals are selected from pigs and poultry.

5. The method according to claim 4 wherein the animals are laying hens.

6. The method according to claim 1 wherein the parasite infestation is a mite infestation.

7. The method according to claim 6 wherein the mite infestation is an infestation with Dermanyssus sp. or Ornithonyssus sp.

8. A Medicated drinking water comprising a mixture of a pharmaceutical composition comprising fluralaner or a salt or solvate thereof, and a pharmaceutically acceptable carrier comprising diethylene glycol monoethyl ether and a polysorbate surfactant and water, wherein the polysorbate is 30 to 80% by weight of the pharmaceutical composition.

9. The Medicated drinking water according to claim 8 comprising between 0.001 and 1 mg/ml of the fluralaner compound.

10. A Method for preparing medicated drinking water according to claim 8 wherein the pharmaceutical composition is diluted by injecting through a dosing pump system in a water system or by mixing with water in a medication tank.

11. The method of claim 1 , wherein the polysorbate surfactant is polysorbate 80.

12. The medicated drinking water of claim 8 , wherein the polysorbate surfactant is polysorbate 80.

Assignees

• Intervet Inc

Inventors

• Lehay Anne
• Flochlay-Sigognault Annie

Classifications

• A61K47/26

  Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin · CPC title

• A61K47/10

  Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers · CPC title

• A61P33/14

  Ectoparasiticides, e.g. scabicides · CPC title

• A61P33/10

  Anthelmintics · CPC title

• A61K9/0095 Primary

  Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches (A61K9/0007 takes precedence; eatable gels or foams A61K9/0056; oral mucosa adhesive forms A61K9/006) · CPC title