Flow cytometer communication system for smart flow cytometers with self monitoring

Patent metadata

Field	Value
Publication number	US-11879826-B2
Application number	US-202117412695-A
Country	US
Kind code	B2
Filing date	Aug 26, 2021
Priority date	Aug 10, 2018
Publication date	Jan 23, 2024
Grant date	Jan 23, 2024

Abstract

In some embodiments, a plurality of smart flow cytometers are coupled into communication with a computer communication network. A central repair server system is coupled into communication with the computer communication network and the plurality of smart flow cytometers. Each of the plurality of smart flow cytometers includes a monitoring system coupled to monitor differing operational parameters of the smart flow cytometer for possible failure. The monitoring system can detect an advanced failure of components based on the operational parameters being monitored. The monitoring system can also detect an advanced need for repair and maintenance based on the operational parameters being monitored.

First claim

What is claimed is:

1. A flow cytometer communication system comprising:
a computer communication network;
a plurality of smart flow cytometers in one or more biological laboratories to analyze biological fluids, the plurality of smart flow cytometers coupled into communication with the computer communication network;
a first central repair server system coupled into communication with the computer communication network and the plurality of smart flow cytometers;
wherein each of the plurality of smart flow cytometers includes a monitoring system configured to monitor a plurality of differing operational parameters of the smart flow cytometer, detect an advanced failure of a plurality of components based on the operational parameters being monitored, and determine an advanced need for repair and maintenance of a smart flow cytometer based on the plurality of differing operational parameters being monitored; and
wherein the monitoring system is configured to
monitor a plurality of differing operational parameters of a laser subsystem and a fluidic subsystem of the smart flow cytometer, and
detect an advanced failure of a plurality of components in the laser subsystem and the fluidic subsystem based on the operational parameters being monitored.

2. The flow cytometer communication system of claim 1 ,
wherein an advanced failure of a component is detected in a failing smart flow cytometer, the failing smart flow cytometer sends a message out from the failing smart flow cytometer to the first central repair server system;
wherein the first central repair server system downloads parameter history associated with the failing component and diagnoses the failure with at least one of a plurality of diagnosis routines that diagnose systems and components of the smart flow cytometer; and
wherein the first central repair server system alerts a user, a manufacturer, and/or a repair technician to provide information about the failing smart flow cytometer, an initial diagnosis of the failing component, and schedules a repair service for the failing smart flow cytometer.

3. The flow cytometer communication system of claim 1 , further comprising:
a remote host computer at a service provider coupled into communication with the computer communication network and at least one of the plurality of smart flow cytometers;
wherein the first central repair server system receives a warning message from the at least one smart flow cytometer, communicates the warning message to the remote host computer of the service provider, and alerts a repair technician of the service provider to further diagnose the at least one smart flow cytometer and schedule a repair service for the at least one smart flow cytometer before the at least one smart flow cytometer fails.

4. The flow cytometer communication system of claim 1 , further comprising:
a remote host computer at a service provider coupled into communication with the computer communication network and at least one of the plurality of smart flow cytometers; and
wherein the first central repair server system receives an alarm message from the at least one smart flow cytometer, communicates the alarm message to the remote host computer of the service provider, and alerts a repair technician of the service provider to further diagnose the at least one smart flow cytometer and immediately provide a repair service for the at least one smart flow cytometer because the at least one smart flow cytometer has failed.

5. The flow cytometer communication system of claim 3 , wherein
the warning message is based on a predetermined warning limit for a component being exceeded.

6. The flow cytometer communication system of claim 4 , wherein
the alarm message is based on a predetermined warning limit and a predetermined alarm limit for a component being exceeded.

7. A flow cytometer communication system comprising:
a computer communication network;
a plurality of smart flow cytometers in one or more biological laboratories to analyze biological fluids, the plurality of smart flow cytometers coupled into communication with the computer communication network;
a first central repair server system coupled into communication with the computer communication network and the plurality of smart flow cytometers;
wherein each of the plurality of smart flow cytometers includes a monitoring system configured to monitor a plurality of differing operational parameters of the smart flow cytometer, detect an advanced failure of a plurality of components based on the operational parameters being monitored, and determine an advanced need for repair and maintenance of a smart flow cytometer based on the plurality of differing operational parameters being monitored; and
wherein the monitoring system is configured to
monitor a plurality of differing operational parameters of a laser subsystem and a receiver subsystem of the smart flow cytometer, and
detect an advanced failure of a plurality of components in the laser subsystem and the receiver subsystem based on the operational parameters being monitored.

8. The flow cytometer communication system of claim 1 , wherein
the monitoring system is further configured to
monitor one or more operational parameters of a receiver subsystem of the smart flow cytometer, and
detect an advanced failure of a component in the receiver subsystem based on the one or more operational parameters being monitored of the receiver subsystem.

9. The flow cytometer communication system of claim 1 , wherein
the monitoring system is configured to
monitor a plurality of differing operational parameters of a receiver subsystem of the smart flow cytometer, and
detect an advanced failure of a plurality of components the receiver subsystem based on the operational parameters being monitored.

10. A flow cytometer communication system comprising:
a computer communication network;
a plurality of smart flow cytometers in one or more biological laboratories to analyze biological fluids, the plurality of smart flow cytometers coupled into communication with the computer communication network;
a first central repair server system coupled into communication with the computer communication network and the plurality of smart flow cytometers;
wherein each of the plurality of smart flow cytometers includes a monitoring system configured to monitor a plurality of differing operational parameters of the smart flow cytometer, detect an advanced failure of a plurality of components based on the operational parameters being monitored, and determine an advanced need for repair and maintenance of a smart flow cytometer based on the plurality of differing operational parameters being monitored; and
wherein each of the plurality of smart flow cytometers further includes a quality control system configured to provide start up validation.

11. The flow cytometer communication system of claim 10 , wherein
the quality control system is further configured to provide a measure of performance monitoring.

Assignees

• Cytek Biosciences Inc

Inventors

• Jiang Janine
• Vrane David

Classifications

• G01N15/1431 Primary

  the electronics being integrated with the analyser, e.g. hand-held devices for on-site investigation · CPC title

• G01N15/1425

  using an analyser being characterised by its control arrangement · CPC title

• G01N15/1434

  Optical arrangements · CPC title

• G01N2015/1438

  Using two lasers in succession · CPC title

• G01N15/1429 Primary

  Signal processing · CPC title