Modulators of G-Protein Coupled Receptors
US-2024383960-A1 · Nov 21, 2024 · US
Methods of treatment comprising Selenoprotein P fragment-containing compounds
US11878997B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11878997-B2 |
| Application number | US-202117363140-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 30, 2021 |
| Priority date | May 2, 2017 |
| Publication date | Jan 23, 2024 |
| Grant date | Jan 23, 2024 |
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- Title
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- Abstract
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Abstract
Official abstract text for this publication.
This invention relates to methods of administering compounds containing selenium, selenocysteine, or a selenocysteine peptide to treat, for example, conditions associated with selenium deficiency, or ferroptoptic, parthanototic, and endoplasmic reticulum stress, and/or cancer. The methods of treatment may activate or inhibit (via TFAP2C and Sp1 proteins) the adaptive homeostatic response of the selenome. The compounds may contain a targeting sequence that causes them to be delivered to specific organs and/or tissues. The compounds may be administered, for example, orally, intranasally, intravenously, or by a minimally invasive catheter or BrainPath.
First claim
Opening claim text (preview).
What is claimed is: 1. A method of treating a subject with ischemic stroke or hemorrhagic stroke, comprising administering to the subject a compound comprising (a) a selenium-containing peptide, wherein the selenium-containing peptide consists of UKUNLN (SEQ ID NO:28), linked to (b) a TAT transduction domain. 2. The method of claim 1 , wherein the compound further comprises (c) a peptide selected from the group consisting of a NA1, PTP-Sigma, GluR2-Gapdh inhibitor sequence, SDK-5 inhibitor sequence, and SS31 sequence. 3. The method of claim 1 , wherein the compound consists of SEQ ID NO:2. 4. The method of claim 1 , wherein the method is for treating hemorrhagic stroke. 5. The method of claim 1 , wherein the method is for treating ischemic stroke. 6. The method of claim 1 , wherein administration of the compound comprises delivery of the compound by catheter. 7. The method of claim 1 , wherein administration of the compound comprises delivery of the compound via parenteral injection.
Assignees
Inventors
Classifications
- C07K14/001Primary
by chemical synthesis · CPC title
Sulfur, selenium, or tellurium compounds, e.g. thiols · CPC title
Peptides having 12 to 20 amino acids {(A61K38/043 - A61K38/046 take precedence)} · CPC title
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof {(enzyme inhibitors A61K38/005)} · CPC title
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title
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- What does patent US11878997B2 cover?
- This invention relates to methods of administering compounds containing selenium, selenocysteine, or a selenocysteine peptide to treat, for example, conditions associated with selenium deficiency, or ferroptoptic, parthanototic, and endoplasmic reticulum stress, and/or cancer. The methods of treatment may activate or inhibit (via TFAP2C and Sp1 proteins) the adaptive homeostatic response of the…
- Who is the assignee on this patent?
- Burke Neurological Inst, Univ Of Vermont And State Agricultural College
- What technology area does this patent fall under?
- Primary CPC classification C07K14/001. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jan 23 2024 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).