Compositions comprising an urolithin compound

Patent metadata

Field	Value
Publication number	US-11878964-B2
Application number	US-202117238525-A
Country	US
Kind code	B2
Filing date	Apr 23, 2021
Priority date	Aug 28, 2015
Publication date	Jan 23, 2024
Grant date	Jan 23, 2024

Abstract

The invention provides compositions comprising a source of protein and a urolithin. The invention also provides uses and methods associated with, or making use of the compositions, such as a medicament, dietary supplement, functional food or medical food and in the treatment and/or prophylaxis of a muscle-related pathological condition. The invention also provides kits comprising urolithin and protein.

First claim

The invention claimed is:

1. A method of improving physical performance, comprising administering to a subject in need thereof an effective amount of a composition comprising a urolithin and a source of protein; wherein the physical performance is walking or running.

2. The method of claim 1 , wherein the subject's performance in the six-minute walk test (MWT) is improved.

3. The method of claim 1 , wherein the subject's time to walk a certain distance (gait speed) is improved.

4. The method of claim 1 , wherein the subject's time to run a certain distance (running speed) is improved.

5. The method of claim 1 , wherein the subject's running economy is improved.

6. The method of claim 1 , wherein the subject's International Physical Activity Questionnaire (IPAQ) score is improved.

7. The method of claim 1 , wherein the subject's number of chair-stands in a certain time is increased.

8. A method of improving muscle function, comprising administering to a subject in need thereof an effective amount of a composition comprising a urolithin and a source of protein; wherein the muscle function is muscle endurance.

9. The method of claim 8 , wherein the subject's muscular contraction strength is increased.

10. The method of claim 8 , wherein the subject's amplitude of muscle contracting is increased.

11. The method of claim 8 , wherein subject's muscle reaction time between stimulation and contraction is shortened.

12. The method of claim 8 , wherein the subject's upper body and/or lower body muscle endurance is improved.

13. The method of claim 12 , wherein the subject's hand grip strength is improved.

14. The method of claim 8 , wherein the subject's skeletal muscle respiratory capacity is increased.

15. The method of claim 14 , wherein the subject's maximal oxygen consumption (VO 2 max ) is increased.

16. The method of claim 8 , wherein the subject's muscle mass is increased.

17. The method of claim 8 , wherein the subject's muscle stem cell regenerative ability is improved.

18. A method of improving physical performance, comprising administering to a subject in need thereof an effective amount of a composition comprising urolithin A and a source of protein.

19. The method of claim 18 , wherein the physical performance is walking or running.

20. A method of improving muscle function, comprising administering to a subject in need thereof an effective amount of a composition comprising urolithin A and a source of protein.

21. The method of claim 20 , wherein the muscle function is muscle endurance.

Assignees

• Amazentis Sa

Inventors

• Andreux Penelope
• Rinsch Christopher L
• Blanco-Bose William

Classifications

• A23V2002/00

  Food compositions, function of food ingredients or processes for food or foodstuffs · CPC title

• A23L33/17

  Amino acids, peptides or proteins · CPC title

• A23L33/10

  using additives (addition of substantially indigestible substances A23L33/21) · CPC title

• A61P25/00

  Drugs for disorders of the nervous system · CPC title

• A61P21/00

  Drugs for disorders of the muscular or neuromuscular system · CPC title