Bioactive glass compositions

Patent metadata

Field	Value
Publication number	US-11878940-B2
Application number	US-202016992534-A
Country	US
Kind code	B2
Filing date	Aug 13, 2020
Priority date	Aug 13, 2019
Publication date	Jan 23, 2024
Grant date	Jan 23, 2024

Abstract

A silicate-based glass composition includes: 50-70 wt. % SiO2, 0.01-10 wt. % P2O5, 10-30 wt. % Na2O, 0.01-10 wt. % CaO, 0.01-10 wt. % MO, and 15-30 wt. % R2O, such that MO is the sum of MgO, CaO, SrO, BeO, and BaO, and R2O is the sum of Na2O, K2O, Li2O, Rb2O, and Cs2O.

First claim

What is claimed is:

1. A fiber filament comprising a silicate-based glass composition, the glass composition comprising:
50-70 wt. % SiO 2 ,
0.01-10 wt. % P 2 O 5 ,
10-30 wt. % Na 2 O,
0.01-10 wt. % CaO,
0.01-10 wt. % MO, and
15-30 wt. % R 2 O,
wherein MO is the sum of MgO, CaO, SrO, BeO, and BaO;
wherein R 2 O is the sum of Na 2 O, K 2 O, Li 2 O, Rb 2 O, and Cs 2 O, and

wherein the fiber filament comprises a biopolymer coating including at least one of: polylactic acid (PLA), polyglyolic acid (PGA), co-polymers thereof (PLGA), poly D,L-lactic acid (PDLLA), poly 3-hydroxybutyrate (P(3HB)), alginate, polycaprolactone (PCL), or polyvinyl-alcohol (PVA).

2. The fiber filament of claim 1 , wherein the glass composition further comprises:
0.01-10 wt. % K 2 O, and
0.01-5 wt. % MgO.

3. The fiber filament of claim 1 , wherein the glass composition further comprises:
0-10 wt. % Al 2 O 3 ,
0-10 wt. % ZnO,
0-10 wt. % B 2 O 3 , and
0-5 wt. % Li 2 O.

4. The fiber filament of claim 1 , wherein the glass composition comprises:
60-70 wt. % SiO 2 ,
5-10 wt. % P 2 O 5 ,
20-30 wt. % Na 2 O,
1-10 wt. % K 2 O,
1-4 wt. % MgO, and
0.01-5 wt. % CaO.

5. The fiber filament of claim 4 , wherein the glass composition further comprises:
1-6 wt. % K 2 O.

6. The fiber filament of claim 4 , wherein the glass composition is essentially free of B 2 O 3 , Al 2 O 3 , ZnO, and Li 2 O.

7. The fiber filament of claim 1 , wherein the glass composition is configured to have a viscosity of at least 100-poise (P) at temperatures in a range of 1000° C. to 1500° C., and a liquidus temperature in a range of 900° C. to 1200° C.

8. The fiber filament of claim 1 , wherein the glass composition is configured for hydroxyapatite formation within seven days of immersion in simulated body fluid (SBF).

9. The fiber filament of claim 8 , wherein the hydroxyapatite formation comprises: granular spherical crystals having at least one size dimension in a range of 0.1-10 μm.

10. The fiber filament of claim 1 , wherein a difference between a glass transition temperature (T g ) of the glass composition and an onset of crystallization temperature (T c,o ) is at least 200° C.

11. The fiber filament of claim 1 produced via a contact coating method by passing the fiber filament through a polymer-containing reservoir.

12. The fiber filament of claim 1 , having a diameter in a range of 5 μm to 25 μm.

13. A yarn comprising at least one fiber filament of claim 1 , where the yarn has at least 50 holes.

14. A textile comprising the fiber filament of claim 1 .

15. A matrix comprising the fiber filament of claim 1 , wherein:
the matrix includes at least one of: a toothpaste, mouthwash, rinse, spray, ointment, salve, cream, bandage, polymer film, oral formulation, pill, capsule, or transdermal formulation.

16. The matrix of claim 15 , wherein the fiber filament is attached to the matrix or mixed therein.

Assignees

• Corning Inc

Inventors

• Fu Qiang
• Zhou Qing

Classifications

• C03C3/097 Primary

  containing phosphorus, niobium or tantalum · CPC title

• C03C4/0007

  for biologically-compatible glass · CPC title

• C03C13/00

  Fibre or filament compositions (manufacture of fibres or filaments C03B37/00) · CPC title

• C03C17/324

  Polyesters · CPC title

• C03C3/087

  containing calcium oxide, e.g. common sheet or container glass · CPC title