Immunomodulatory Combinations of Antigen and Drug-Lipid Conjugate
US-2024374734-A1 · Nov 14, 2024 · US
Nanoparticle/peptide method of blocking potassium channels
US11878064B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11878064-B2 |
| Application number | US-202318170229-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 16, 2023 |
| Priority date | Sep 12, 2019 |
| Publication date | Jan 23, 2024 |
| Grant date | Jan 23, 2024 |
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- Title
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Abstract
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A nanoparticle (NP)-peptide conjugate provides efficient steric hindrance/blockage of cellular membrane potassium (K + ) channels to mediate depolarization of cellular membrane potential.
First claim
Opening claim text (preview).
What is claimed is: 1. A method of blocking potassium channels, comprising: providing a construct comprising a gold nanoparticle conjugated to a peptide comprising SEQ ID NO: 1 and a spacer sequence; and contacting mammalian cells with the construct, thereby blocking potassium channels on the mammalian cells. 2. The method of claim 1 , wherein the peptide consists of SEQ ID NO: 3. 3. The method of claim 1 , further comprising applying heat to the nanoparticle, thus at least partially releasing the blockage of potassium channels.
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Classifications
- A61K47/6929Primary
the form being a nanoparticle, e.g. an immuno-nanoparticle · CPC title
from animals; from humans {(enzyme inhibitors A61K38/005)} · CPC title
the modifying agent being an inorganic compound, e.g. an inorganic ion that is complexed with the active ingredient · CPC title
- A61K38/1767Primary
from invertebrates · CPC title
the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb · CPC title
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Frequently asked questions
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- What does patent US11878064B2 cover?
- A nanoparticle (NP)-peptide conjugate provides efficient steric hindrance/blockage of cellular membrane potassium (K + ) channels to mediate depolarization of cellular membrane potential.
- Who is the assignee on this patent?
- Us Dept Of The Navy, Us Gov Sec Navy
- What technology area does this patent fall under?
- Primary CPC classification A61K47/6929. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Jan 23 2024 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).