Systems and methods for delivery of gel embolics

Patent metadata

Field	Value
Publication number	US-11877753-B2
Application number	US-202117376769-A
Country	US
Kind code	B2
Filing date	Jul 15, 2021
Priority date	Apr 1, 2015
Publication date	Jan 23, 2024
Grant date	Jan 23, 2024

Abstract

Delivery systems for liquid embolics and methods of using them are disclosed. The devices generally include a catheter and one or more retention elements to limit migration of the liquid embolic to non-target sites.

First claim

What is claimed is:

1. A system for treating a patient, the system comprising:
a catheter;
at least one retention element slidably disposed within the catheter;
an embolic material flowable or slidable through a lumen of the catheter; and
a pushrod comprising an elongate body slidably disposed within the catheter;
wherein the system is configured such that when the catheter is positioned in a body lumen and the catheter is retracted relative to the pushrod or the pushrod is advanced relative to the catheter, the at least one retention element and the embolic material are delivered from the catheter into the body lumen;
wherein the at least one retention element is configured to move from an unexpanded configuration to an expanded configuration within the body lumen and retain the embolic material substantially proximal to the at least one retention element within the body lumen; and
wherein the retention member is configured to be released and remain in the body with the embolic material.

2. The system of claim 1 , wherein the embolic material absorbs water when disposed in an aqueous environment.

3. The system of claim 1 , wherein the embolic material forms a gel.

4. The system of claim 1 , wherein the embolic material is a superabsorbent polymer plug.

5. The system of claim 1 , wherein the at least one retention element comprises a first retention element and a second retention element disposed proximally and distally about the embolic material, respectively.

6. The system of claim 5 , wherein the first retention element and the second retention element are connected to one another by an elongate member extending between them.

7. The system of claim 1 , comprising a link disposed on an end of the pushrod, the link detachably connecting the end of the pushrod to the at least one retention element.

8. A system for treating a patient, the system comprising:
a catheter;
at least one retention element slidably disposed within the catheter;
a liquid embolic material flowable through a lumen of the catheter;
an elongate body connected to the at least one retention element; and
a detachable link disposed on the elongate body;
wherein the at least one retention element is configured to move from an unexpanded configuration to an expanded configuration within a body lumen and retain the liquid embolic material substantially proximal to the at least one retention element within the body lumen.

9. The system for treating a patient of claim 8 , wherein the elongate body is a pushrod.

10. The system for treating a patient of claim 8 , wherein the liquid embolic is a material that changes from a liquid to a gel or a solid in situ.

11. The system for treating a patient of claim 8 , wherein the liquid embolic is a material that polymerizes, cross-links, or viscifies to form a gel or a solid in situ.

12. The system of claim 8 , wherein the elongate body is a shape memory wire.

13. The system for treating a patient of claim 12 , wherein the catheter is a multi-lumen catheter comprising a first lumen and a second lumen.

14. The system for treating a patient of claim 13 , wherein that shape memory wire is configured to be positioned in the first lumen and the liquid embolic material is configured to be flowed through the second lumen.

15. The system for treating a patient of claim 12 , wherein the shape memory wire is configured to be severed, such that the retention element, a distal portion of the shape memory wire, and the liquid embolic material are delivered to the body lumen.

16. The system of claim 8 , wherein the at least one retention element is moveable between the unexpanded configuration characterized by a first diameter and the expanded configuration characterized by a second diameter larger than the first diameter.

17. The system of claim 8 , wherein the at least one retention element comprises a spiral shape.

18. The system of claim 8 , wherein the at least one retention element comprises a plurality of cross-members.

19. The system of claim 8 , wherein the at least one retention element has a substantially planar structure.

20. A system for treating a patient, the system comprising:
a catheter;
at least one retention element slidably disposed within the catheter;
a liquid embolic material flowable through a lumen of the catheter;
a pushrod comprising an elongate body slidably disposed within the catheter; and
a detachable link disposed on the elongate body, the elongate body being one of an electrolytically severable segment, a mechanical link, and a thermally severable segment;
wherein the system is configured such that when the catheter is positioned in a body lumen and the catheter is retracted relative to the pushrod or the pushrod is advanced relative to the catheter, the at least one retention element and the liquid embolic material are delivered from the catheter into the body lumen and wherein the at least one retention element is configured to move from an unexpanded configuration to an expanded configuration within the body lumen and retain the liquid embolic material substantially proximal to the at least one retention element within the body lumen.

Assignees

• Boston Scient Scimed Inc

Inventors

• Connolly Joseph
• Pederson Gary
• Anderson Mary-Claire
• Haverkost Patrick
• Raab David
• Smith Mark

Classifications

• A61B17/1219 Primary

  expandable in contact with liquids · CPC title

• A61B17/12022

  Occluding by internal devices, e.g. balloons or releasable wires (plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20) · CPC title

• A61B17/12113

  within an aneurysm · CPC title

• A61B17/12159

  Solid plugs; being solid before insertion · CPC title

• A61B17/12172

  having a pre-set deployed three-dimensional shape (methods of manufacturing A61B2017/00526) · CPC title