Compounds and uses thereof

Patent metadata

Field	Value
Publication number	US-11873298-B2
Application number	US-201816758495-A
Country	US
Kind code	B2
Filing date	Oct 24, 2018
Priority date	Oct 24, 2017
Publication date	Jan 16, 2024
Grant date	Jan 16, 2024

Abstract

The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

First claim

What is claimed is:

1. A compound, or pharmaceutically acceptable salt thereof, having the structure of any one of the following compounds:

#
Structure

1241

1238

1237

1236

1232

1231

1228

1227

1226

1225

1110

1111

2. A pharmaceutical composition comprising a compound, or pharmaceutically acceptable salt thereof, of claim 1 , and a pharmaceutically acceptable excipient.

3. A method of alleviating the symptoms associated with a neurological disorder in a subject in need thereof, the method comprising administering an effective amount of a compound, or pharmaceutically acceptable salt thereof, of claim 1 .

4. A method of inhibiting toxicity in a cell related to a protein, the method comprising administering an effective amount of a compound, or pharmaceutically acceptable salt thereof, of claim 1 .

5. The method of claim 4 , wherein the toxicity is α-synuclein -related toxicity.

6. The method of claim 4 , wherein the toxicity is ApoE4-related toxicity.

7. The method of claim 4 , wherein the cell is a mammalian neural cell.

8. A method of alleviating the symptoms associated with a stearoyl-CoA desaturase (SCD)-associated disorder in a subject in need thereof, the method comprising administering an effective amount of a compound, or pharmaceutically acceptable salt thereof, of claim 1 .

Assignees

• Janssen Pharmaceutica Nv

Inventors

• Lucas Matthew
• Le Bourdonnec Bertrand
• Wrona Iwona
• Pandya Bhaumik
• Tivitmahaisoon Parcharee
• Ozboya Kerem
• Vincent Benjamin
• Tardiff Daniel
• Piotrowski Jeff
• Solis Eric
• Scannevin Robert
• Chung Chee-Yeun
• Aron Rebecca
• Rhodes Kenneth

Classifications

• G01N33/575

  for cancer · CPC title

• C07D413/14 Primary

  containing three or more hetero rings · CPC title

• C07D271/07

  with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical · CPC title

• C07D413/04

  directly linked by a ring-member-to-ring-member bond · CPC title

• C07D413/10

  linked by a carbon chain containing aromatic rings · CPC title