Treatment of pain using electrical nerve conduction block

Patent metadata

Field	Value
Publication number	US-11872394-B2
Application number	US-202117319180-A
Country	US
Kind code	B2
Filing date	May 13, 2021
Priority date	Jun 15, 2012
Publication date	Jan 16, 2024
Grant date	Jan 16, 2024

Abstract

Described herein are systems and methods for the treatment of pain using electrical nerve conduction block (ENCB). Contrary to other methods of pain treatment, the ENCB can establish a direct block of neural activity, thereby eliminating the pain. Additionally, the ENCB can be administered without causing electrochemical damage. An example method can include: placing at least one electrode contact in electrical communication with a region of a subject's spinal cord; applying an electrical nerve conduction block (ENCB) to a nerve in the region through the at least one electrode contact; and blocking neural activity with the ENCB to reduce the pain or other unwanted sensation in the subject.

First claim

The following is claimed:

1. A method for treating pain in a patient, comprising:
delivering an electrical waveform comprising a therapy signal to the patient's spinal cord from a waveform generator via at least one electrode comprising at least one contact in electrical communication with the patient's spinal cord,
wherein the electrical waveform is a multi-phase direct current waveform, wherein the multi-phase direct current waveform comprises an anodic phase and a cathodic phase, the anodic phase and the cathodic phase both comprising a ramp segment and a plateau segment,
wherein one of the anodic phase or the cathodic phase provides the therapy signal to the spinal cord, and the subsequent one of the anodic phase or the cathodic phase reduces or balances a return charge,
wherein the at least one contact comprises a high charge capacity titanium nitride or platinum material that limits formation of irreversible reaction products when the electrical waveform delivers a charge of 100 μC or more to the spinal cord.

2. The method of claim 1 , wherein the anodic phase provides the therapy signal.

3. The method of claim 1 , wherein the cathodic phase provides the therapy signal.

4. The method of claim 1 , wherein the pain is acute pain.

5. The method of claim 1 , wherein the pain is chronic pain.

6. The method of claim 1 , wherein the electrical waveform is a continuous waveform.

7. The method of claim 1 , wherein the electrical waveform is an interrupted waveform.

8. The method of claim 1 , wherein the at least one electrode comprises platinum coated with titanium nitride.

9. A method for treating pain in a patient, comprising:
delivering an electrical waveform comprising a therapy signal to the patient's spinal cord from a waveform generator via at least one electrode comprising at least one contact in electrical communication with the patient's spinal cord,
wherein the electrical waveform is a multi-phase direct current waveform, wherein the multi-phase direct current waveform comprises an anodic phase and a cathodic phase, the anodic phase and the cathodic phase both comprising a ramp segment and a plateau segment,
wherein one of the anodic phase or the cathodic phase provides the therapy signal to the spinal cord, and the other of the anodic phase or the cathodic phase reduces or balances a return charge,
wherein the at least one contact comprises a high charge capacity titanium nitride or platinum material that limits formation of irreversible reaction products when the electrical waveform delivers a charge of 10 μC or more to the spinal cord.

10. The method of claim 9 , wherein a period of the anodic phase is about equal to a period of the cathodic phase.

11. The method of claim 9 , wherein the waveform is charge-imbalanced, wherein the charge imbalance is less than 10%.

12. The method of claim 9 , further comprising delivering another electrical waveform to the patient's spinal cord comprising a high-frequency alternating current signal.

13. The method of claim 12 , wherein the high-frequency alternating current signal has a frequency of at least about 1 kHz.

14. The method of claim 12 , wherein the high-frequency alternating current signal has a frequency of between about 5 kHz and about 50 kHz.

15. A method for treating pain in a patient, comprising:
delivering an electrical waveform to the patient's neural tissue from a waveform generator via at least one electrode comprising at least one contact in electrical communication with the patient's neural tissue,
wherein the electrical waveform is a multi-phase direct current waveform, wherein the multi-phase direct current waveform comprises an anodic phase and a cathodic phase, the anodic phase and the cathodic phase both comprising a first ramp segment, a second ramp segment, and a third ramp segment,
wherein one of the anodic phase or the cathodic phase provides a therapy signal to the neural tissue, and the other of the anodic phase or the cathodic phase reduces or balances a return charge,
wherein the at least one contact comprises a high charge capacity titanium nitride or platinum material that limits formation of irreversible reaction products when the electrical waveform delivers a charge of 10 μC or more to the neural tissue,
wherein the multi-phase direct current waveform has a period of about 15 seconds or more.

16. The method of claim 15 , wherein the electrode comprises a cuff electrode.

17. The method of claim 15 , wherein the electrode comprises a paddle electrode.

18. The method of claim 15 , wherein the electrode comprises a mesh electrode.

19. The method of claim 15 , wherein the anodic phase and the cathodic phase further comprise a first plateau segment in between the first ramp segment and the second ramp segment.

20. The method of claim 19 , wherein the anodic phase and the cathodic phase further comprise a second plateau segment in between the second ramp segment and the third ramp segment.

21. The method of claim 20 , wherein a beginning and an end of the anodic phase and the cathodic phase are defined by at least two of said ramp segments.

Assignees

• Univ Case Western Reserve
• Case Western Reserve Univeraity
• Nat Institutes Of Health Nih U S Dept Of Health And Human Services Dhhs U S Government

Inventors

• Bhadra Niloy
• Bhadra Narendra
• Kilgore Kevin L
• Lempka Scott
• Wainright Jesse
• Vrabec Tina
• Franke Manfred

Classifications

• A61N1/0551 Primary

  Spinal or peripheral nerve electrodes · CPC title

• A61N1/06

  for high-frequency therapy · CPC title

• A61N1/20

  continuous direct currents · CPC title

• A61N1/36021

  for treatment of pain · CPC title

• A61N1/36062

  Spinal stimulation · CPC title