Enhanced-flexibility transducer arrays for delivering TTFields (tumor treating fields)

Patent metadata

Field	Value
Publication number	US-11872391-B2
Application number	US-202117545248-A
Country	US
Kind code	B2
Filing date	Dec 8, 2021
Priority date	Nov 29, 2018
Publication date	Jan 16, 2024
Grant date	Jan 16, 2024

Abstract

A transducer array for use in tumor-treating fields (TTFields) therapy is particularly suited for use in treating abdominal or thoracic cancers. The transducer array has features that increase its flexibility and adhesion to the patient's skin, including a branching configuration and a correspondingly branching top covering adhesive-backed layer. Additionally, a skin-level adhesive layer is provided beneath the flex circuit to which the electrode elements are attached, to help ensure thorough, lasting adhesion of the transducer array to the patient's skin over the course of treatment.

First claim

What is claimed is:

1. An electrode apparatus configured for affixation to a patient's skin, comprising:
a flex circuit having a trunk region that extends in a longitudinal direction and a plurality of branches that extend laterally from the trunk region, each of the branches having a free distal end and a proximal end that is connected to the trunk region, with a plurality of branches extending on at least one lateral side of the trunk region, the flex circuit having an inner skin-facing side and an outer side;
a plurality of electrode elements disposed on the inner side of the flex circuit along the branches of the flex circuit, each of the electrode elements having a conductive plate that is connected to the flex circuit in an electrically conducting manner, and a dielectric layer positioned and adapted to be facing the skin of the patient;
a foam layer disposed on the inner side of the flex circuit, wherein the foam layer is configured to cover at least a portion of the trunk region of the flex circuit and at least a portion of the branches of the flex circuit, and leave the electrode elements uncovered;
a skin-level adhesive layer disposed on a skin-facing side of the foam layer; and
a top, covering layer disposed on the outer side of the flex circuit, the covering layer being sized to cover the branches of the flex circuit and to overlap spaces between the branches, the covering layer having adhesive on a skin-facing side thereof by means of which the covering layer can be adhered to an underlying surface through the spaces between the branches.

2. The electrode apparatus of claim 1 , further comprising a plurality of conductive hydrogel discs wherein each of the conductive hydrogel discs is attached to a skin-facing side of a respective electrode element.

3. The electrode apparatus of claim 1 , wherein the covering layer is slotted to define a plurality of fingers overlying the branches of the flex circuit so that the fingers of the covering layer can move independently of each other as branches of the flex circuit flex independently of each other.

4. The electrode apparatus of claim 1 , wherein the flex circuit has a plurality of branches extending on each lateral side of the trunk region.

5. The electrode apparatus of claim 1 , wherein the foam layer is configured to cover the entire surface of the flex circuit, except for regions where the electrode elements are positioned.

6. The electrode apparatus of claim 2 , further comprising a plurality of gel barriers, wherein each of the gel barriers surrounds a respective one of the hydrogel discs.

7. The electrode apparatus of claim 1 , wherein more electrode elements are attached to branches of the flex circuit that are closer to the longitudinal center of the trunk than are attached to branches of the flex circuit that are closer to the longitudinal ends of the trunk.

8. The electrode apparatus of claim 1 , wherein the trunk shifts back and forth in the lateral direction as it extends in the longitudinal direction.

9. The electrode apparatus of claim 1 , wherein the trunk extends in the longitudinal direction in a straight manner.

10. The electrode apparatus of claim 1 , wherein the skin-level adhesive layer has a configuration that follows the configuration of the flex circuit, with branches and trunk portions of the skin-level adhesive layer being wider than corresponding portions of the flex circuit so as to overlap spaces between the branches of the flex circuit.

11. The electrode apparatus of claim 1 , wherein the flex circuit has a plurality of branches which are present only on a single lateral side of the trunk region.

12. The electrode apparatus of claim 1 , wherein the flex circuit is configured so that no more than three paths emanate from any intersection on the flex circuit.

13. The electrode apparatus of claim 1 , wherein the flex circuit is configured so that one or more intersections on the flex circuit exist from which four paths emanate.

14. The electrode apparatus of claim 1 , wherein the flex circuit is configured so that all segments of the flex circuit are straight.

15. The electrode apparatus of claim 1 , further comprising an electrical cable that terminates on the flex circuit.

16. The electrode apparatus of claim 15 , wherein segments of the flex circuit near the distal end of each branch are thinner than at least some of the segments of the flex circuit that are adjacent to the electrical cable.

Assignees

• Novocure Gmbh

Inventors

• Kirson Eilon
• Wasserman Yoram
• Halavee Noa

Classifications

• A61N1/36014

  External stimulators, e.g. with patch electrodes (external pacemakers A61N1/3625) · CPC title

• A61N1/0496

  characterised by using specific chemical compositions, e.g. hydrogel compositions, adhesives · CPC title

• A61N1/0476

  Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities) · CPC title

• A61N1/36002 Primary

  Cancer treatment, e.g. tumour · CPC title

• A61N1/0492 Primary

  Patch electrodes (A61N1/0412, A61N1/0428 take precedence) · CPC title