Detecting and treating COPD-OSA overlap syndrome

Patent metadata

Field	Value
Publication number	US-11872344-B2
Application number	US-202017015451-A
Country	US
Kind code	B2
Filing date	Sep 9, 2020
Priority date	Sep 30, 2019
Publication date	Jan 16, 2024
Grant date	Jan 16, 2024

Abstract

The present ventilator system, for detecting and treating concurrent chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA event(s)) overlap syndrome, comprises a pressure generator for generating a pressurized flow of breathable gas for delivery to an airway of a subject; sensor(s) for generating output signals conveying information related to breathable gas parameters; and processor(s) operatively connected to the sensor(s) and the pressure generator, configured to: detect presence of OSA event(s) and/or expiratory flow limitation (EFL) in the subject based on the output signals. Responsive to detecting concurrent presence of OSA event(s) and EFL, the processors are configured to determine OSA EVENT(S) therapy parameters for treating the detected OSA event(s) in the subject; determine EFL therapy parameters for treating the detected EFL in the subject; determine a priority treatment based on a comparison between the OSA event(s) therapy parameters and the EFL therapy parameters; and control the pressure generator.

First claim

What is claimed is:

1. A ventilator system for detecting and treating concurrent chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) event(s) overlap syndrome, the ventilator system comprising:
a pressure generator configured to generate a pressurized flow of breathable gas for delivery to an airway of a subject;
one or more sensors configured to generate output signals conveying information related to one or more parameters related to the breathable gas; and
one or more physical computer processors operatively connected to the one or more sensors and the pressure generator, the one or more physical computer processors configured by computer readable instructions to:
detect presence of obstructive sleep apnea OSA event(s) and/or expiratory flow limitation (EFL) in the subject based on the output signals; and
responsive to detecting concurrent presence of the OSA event(s) and the EFL:
determine one or more OSA event(s) therapy parameters indicative of one or more of a first pressure, a first flow, and a first volume for treating the detected obstructive sleep apnea in the subject;
determine one or more EFL therapy parameters indicative of one or more of a second pressure, a second flow, and a second volume for treating the detected expiratory flow limitation in the subject;
determine a priority treatment based on a comparison between the one or more OSA event(s) therapy parameters and the one or more EFL therapy parameters; and

control the pressure generator to deliver the determined priority treatment to the subject.

2. The ventilator system of claim 1 , wherein detecting presence of OSA event(s) in the subject comprises detecting upper airway obstruction in the subject based on the output signals.

3. The ventilator system of claim 1 , wherein the one or more physical computer processors are further configured to:
responsive to a first OSA event therapy parameter being greater than a corresponding first EFL therapy parameter, control the ventilator system to deliver a cumulative first parameter, the cumulative first parameter being a cumulative of the first OSA event therapy parameter and a first parameter offset; and
responsive to the first EFL therapy parameter being greater than or equal to the first OSA event therapy parameter, control the ventilator system to deliver the first EFL therapy parameter.

4. The ventilator system of claim 1 , wherein the one or more OSA event(s) therapy parameters comprise the first pressure for treating OSA event(s) (POSA).

5. The ventilator system of claim 1 , wherein the one or more EFL therapy parameters comprise the second pressure for treating EFL (PEFL).

6. The ventilator system of claim 1 , wherein the one or more physical computer processors are further configured to: deliver a forced oscillation technique (FOT) to determine the one or more OSA event(s) therapy parameters and/or the one or more EFL therapy parameters.

7. The ventilator system of claim 1 , wherein the one or more physical computer processors are further configured to: prioritize treatment of the detected OSA event(s) over treatment for the detected EFL.

8. The ventilator system of claim 1 , wherein detecting presence of the OSA event(s) in the subject comprises detecting upper airway obstruction in the subject based on an apnea and hypopnea index AHI).

9. A method for detecting and treating concurrent chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) event overlap syndrome with a ventilator system comprising a pressure generator, one or more sensors, and one or more physical computer processors, the method comprising:
generating a pressurized flow of breathable gas for delivery to an airway of a subject with the pressure generator;
generating output signals conveying information related to one or more parameters of the breathable gas with the one or more sensors;
detecting, with the one or more physical computer processors presence of obstructive sleep apnea OSA event(s) and/or expiratory flow limitation (EFL) in the subject based on the output signals;
responsive to detecting concurrent presence of the OSA event(s) and the EFL:
determining, with the one or more physical computer processors, one or more OSA event(s) therapy parameters indicative of one or more of a first pressure, a first flow, and a first volume for treating the detected obstructive sleep apnea in the subject;
determining, with the one or more physical computer processors, one or more EFL therapy parameters indicative of one or more of a second pressure, a second flow, and a second volume for treating the detected expiratory flow limitation in the subject;
determining, with the one or more physical computer processors, a priority treatment based on a comparison between the one or more OSA event(s) therapy parameters and the one or more EFL therapy parameters; and
controlling, with the one or more physical computer processors, the pressure generator to deliver the determined priority treatment to the subject.

10. The method of claim 9 , wherein detecting the presence of OSA event(s) in the subject comprises detecting upper airway obstruction in the subject based on the output signals.

11. The method of claim 9 , further comprising:
responsive to a first OSA event(s) therapy parameter being greater than a corresponding first EFL therapy parameter, controlling the ventilator system to deliver a cumulative first parameter, the cumulative first parameter being a cumulative of the first OSA event(s) therapy parameter and a first parameter offset; and
responsive to the first EFL therapy parameter being greater than or equal to the first OSA event(s) therapy parameter, controlling the ventilator system to deliver the first EFL therapy parameter.

12. The method of claim 9 , wherein the one or more OSA event(s) therapy parameters comprise the first pressure for treating OSA event(s) (POSA).

13. The method of claim 9 , wherein the one or more EFL therapy parameters comprise the second pressure for treating EFL (PEFL).

14. The method of claim 9 , further comprising: delivering a forced oscillation technique (FOT) to determine the one or more OSA event(s) therapy parameters and/or the one or more EFL therapy parameters.

15. The method of claim 9 , further comprising: prioritizing treatment of the detected OSA event(s) over treatment for the detected EFL.

16. The method of claim 9 , wherein detecting presence of OSA event(s) in the subject comprises detecting upper airway obstruction in the subject based on an apnea and hypopnea index (AHI).

17. A ventilator system for detecting and treating concurrent chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) event(s) overlap syndrome, the ventilator system comprising:
means for generating a pressurized flow of breathable gas for delivery to the airway of a subject;
means for generating output signals conveying information related to one or more parameters of the breathable gas;
means for detecting, with the one or more physical computer processors presence of obstructive sleep apnea OSA event(s) and/or expiratory flow limitation (EFL) in the subject based on the output signals; and
means for, responsive to detecting concurrent presence of the OSA event(s) and the EFL:
determining one or more OSA event(s) therapy parameters indicative of one or more of a first pressure, a first flow, and a first volume for treating the detected obstructive sleep apnea in the subject;
determining one or more EFL therapy parameters indicative of one or more of a second pressure, a

Assignees

• Koninklijke Philips Nv

Inventors

• Romano Robert
• Mckenzie Jr Richard James

Classifications

• A61M16/06 Primary

  Respiratory or anaesthetic masks · CPC title

• A61M16/0003

  Accessories therefor, e.g. sensors, vibrators, negative pressure · CPC title

• A61M16/024

  including calculation means, e.g. using a processor · CPC title

• A61M2205/50

  with microprocessors or computers · CPC title

• A61B5/0826 Primary

  Detecting or evaluating apnoea events (sleep apnoea A61B5/4818) · CPC title