Lubricious medical device coating with low particulates

Patent metadata

Field	Value
Publication number	US-11872325-B2
Application number	US-202117161396-A
Country	US
Kind code	B2
Filing date	Jan 28, 2021
Priority date	Jan 18, 2012
Publication date	Jan 16, 2024
Grant date	Jan 16, 2024

Abstract

Embodiments of the invention include lubricious medical device coatings. In an embodiment the invention includes a coating for a medical device including a first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group; and a first cross-linking agent comprising at least two photoreactive groups; a second layer disposed on the first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group; a second cross-linking agent comprising at least two photoreactive groups; and a polymer comprising polyacrylamide, the polymer derivatized with at least one photoreactive group. Other embodiments are included herein.

First claim

The invention claimed is:

1. A medical device comprising:
a substrate; and
a first layer disposed on the substrate, the first layer comprising
polyvinylpyrrolidone derivatized with a photoreactive group;
at least one acrylamide containing copolymer selected from the group consisting of poly[acrylamide-co-sodium-2-acrylamido-2-methylpropanesulfonate-co-N-(3-(4-benzoylbenzamido)propyl)methacrylamide] and N-Acetylated poly[acrylamide-co-sodium-2-acrylamido-2-methylpropanesulfonate-co-N-(3-(4-benzoylbenzamido)propyl)methacrylamide]-co-methoxy poly(ethylene glycol) monomethacrylate; and
sodium bis(4-benzoylphenyl) phosphate (BPP).

2. The medical device of claim 1 , wherein the coating releases less than 10,000 particles greater than 10 microns in size when exposed to an aqueous environment.

3. The medical device of claim 1 , wherein the ratio of polyvinylpyrrolidone derivatized with a photo reactive group in the first layer to sodium bis(4-benzoylphenyl) phosphate (BPP) is from about 2:1 to about 30:1 (wt./wt.).

4. The medical device of claim 1 , wherein the ratio of polyvinylpyrrolidone derivatized with a photo reactive group in the first layer to sodium bis(4-benzoylphenyl) phosphate (BPP) is from about 8:1 to about 16:1 (wt./wt.).

5. The medical device of claim 1 , the first layer further comprising non-derivatized polyvinylpyrrolidone.

6. The medical device of claim 1 , the coating exhibiting a lubricity when wetted of between 0 and 30 grams of force.

7. The medical device of claim 1 , the coating exhibiting a lubricity when wetted of between 0 and 30 grams of force for at least 10 consecutive testing cycles.

8. The medical device of claim 1 , the coating exhibiting a durability of lubricity such there is less than a 30 percent increase in measured friction between the average of cycles 1-5 of testing and cycles 10-15 of testing.

9. The medical device of claim 1 , wherein the thickness of the first layer is between about 100 and 3000 nm when dry.

10. The medical device of claim 1 , wherein the photoreactive group is benzophenone.

11. The medical device of claim 1 , wherein the medical device is a balloon catheter.

12. The medical device of claim 1 , the substrate comprising a catheter shaft.

13. The medical device of claim 1 , the substrate comprising a metal or a polymer.

14. A medical device comprising:
a substrate; and
a first layer disposed on the substrate, the first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group;
N-Acetylated poly[acrylamide-co-sodium-2-acrylamido-2-methylpropanesulfonate-co-N-(3-(4-benzoylbenzamido)propyl)methacrylamide]-co-methoxy poly(ethylene glycol) monomethacrylate; and
sodium bis(4-benzoylphenyl) phosphate (BPP).

15. The medical device of claim 14 , wherein the coating releases less than 10,000 particles greater than 10 microns in size when exposed to an aqueous environment.

16. The medical device of claim 14 , wherein the ratio of polyvinylpyrrolidone derivatized with a photo reactive group in the first layer to sodium bis(4-benzoylphenyl) phosphate (BPP) is from about 2:1 to about 30:1 (wt./wt.).

17. The medical device of claim 14 , wherein the ratio of polyvinylpyrrolidone derivatized with a photo reactive group in the first layer to sodium bis(4-benzoylphenyl) phosphate (BPP) is from about 8:1 to about 16:1 (wt./wt.).

18. The medical device of claim 14 , wherein the photoreactive group is benzophenone.

19. The medical device of claim 14 , wherein the medical device is a balloon catheter.

20. The medical device of claim 14 , the substrate comprising a catheter shaft.

Assignees

• Surmodics Inc

Inventors

• Babcock David E

Classifications

• A61L29/085 Primary

  Macromolecular materials · CPC title

• A61L27/34

  Macromolecular materials · CPC title

• A61L29/14

  Materials characterised by their function or physical properties {, e.g. lubricating compositions} · CPC title

• A61L31/10

  Macromolecular materials · CPC title

• A61L2400/10

  Materials for lubricating medical devices · CPC title