Use of n-(4-((3-(2-amino-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-4-(4-methyl-2-thienyl)-1-phthalazinamine in combination with histone deacetylase inhibitors for treatment of cancer
US-2015072988-A1 · Mar 12, 2015 · US
Pharmaceutical combinations comprising a histone deacetylase inhibitor and an aurora kinase inhibitor and methods of use thereof
US11872227B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11872227-B2 |
| Application number | US-202217741146-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 10, 2022 |
| Priority date | Oct 28, 2016 |
| Publication date | Jan 16, 2024 |
| Grant date | Jan 16, 2024 |
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- Title
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Abstract
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The present disclosure relates to a pharmaceutical combination comprising (a) a histone deacetylase 6 inhibitor and (b) an aurora kinase inhibitor, including combined preparations and pharmaceutical compositions thereof; uses of such combination in the treatment or prevention of cancer; and methods of treating or preventing cancer in a subject comprising administering a therapeutically effective amount of such combination.
First claim
Opening claim text (preview).
The invention claimed is: 1. A pharmaceutical combination comprising a histone deacetylase 6 (HDAC6) inhibitor and an aurora kinase inhibitor, wherein the HDAC6 inhibitor is or a pharmaceutically acceptable salt thereof and the aurora kinase inhibitor is alisertib, or a pharmaceutically acceptable salt thereof. 2. The pharmaceutical combination of claim 1 , wherein the HDAC6 inhibitor and the aurora kinase inhibitor are in the same formulation. 3. The pharmaceutical combination of claim 1 , wherein the HDAC6 inhibitor and the aurora kinase inhibitor are in separate formulations. 4. The pharmaceutical combination of claim 1 , wherein the combination is for simultaneous or sequential administration.
Assignees
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Classifications
- A61K31/505Primary
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim · CPC title
- A61K31/55Primary
having seven-membered rings, e.g. azelastine, pentylenetetrazole · CPC title
Antineoplastic agents · CPC title
containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole (nicotine A61K31/465) · CPC title
Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin · CPC title
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- What does patent US11872227B2 cover?
- The present disclosure relates to a pharmaceutical combination comprising (a) a histone deacetylase 6 inhibitor and (b) an aurora kinase inhibitor, including combined preparations and pharmaceutical compositions thereof; uses of such combination in the treatment or prevention of cancer; and methods of treating or preventing cancer in a subject comprising administering a therapeutically effectiv…
- Who is the assignee on this patent?
- Acetylon Pharmaceuticals Inc
- What technology area does this patent fall under?
- Primary CPC classification A61K31/505. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Jan 16 2024 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).