Handheld drug delivery device

Patent metadata

Field	Value
Publication number	US-11865310-B2
Application number	US-202016872230-A
Country	US
Kind code	B2
Filing date	May 11, 2020
Priority date	Nov 9, 2017
Publication date	Jan 9, 2024
Grant date	Jan 9, 2024

Abstract

Handheld drug delivery devices for injection of a medicament into a target location are disclosed herein. The drug delivery devices of the present disclosure include drive mechanisms, needle insertion mechanisms, and fluid pathway connectors. These components may be arranged within a housing. The arrangement of these components may provide an easy to use device that is capable of delivering volumes larger than traditionally injected using syringes. Translation of a drug container of the device may cause connection of a fluid pathway from the drug container for delivery of a medicament to a target location.

First claim

The invention claimed is:

1. A drug delivery device comprising:
a housing having a proximal end and a distal end;
an activation mechanism disposed at the proximal end of the housing;
a drive mechanism disposed in the housing the drive mechanism including a biasing member;
a drug container disposed in the housing, the drug container defining a longitudinal drug container axis;
a fluid pathway connection disposed in the housing, the fluid pathway connection including a piercing member defining a longitudinal piercing member axis;
a needle insertion mechanism disposed in the distal end of the housing, the needle insertion mechanism including an insertion needle defining a longitudinal insertion needle axis and further including an insertion biasing member retained in a compressed state at the distal end of the housing,
wherein the longitudinal drug container axis, the longitudinal piercing member axis, and the longitudinal insertion needle axis are substantially coaxial; and
a plunger seal disposed in the drug container, wherein the biasing member of the drive mechanism is configured to apply a force on the plunger seal in response to actuation of the activation mechanism, the force directed toward a distal end of the drug container, and
wherein upon actuating the activation mechanism, the insertion biasing member decompresses, thereby driving and causing the insertion needle to extend in a distal direction toward the distal end of the housing.

2. The drug delivery device of claim 1 , wherein the force applied by the biasing member of the drive mechanism is configured to cause the drug container to translate in the distal direction.

3. The drug delivery device of claim 2 , further comprising a pierceable seal disposed at the distal end of the drug container and wherein displacement of the drug container is configured to cause the piercing member of the fluid pathway connection to pierce the pierceable seal to open a fluid pathway from the drug container, through the piercing member and to the needle insertion mechanism.

4. The drug delivery device of claim 2 , wherein the insertion biasing member is configured to cause the insertion needle to extend in the distal direction in response to the translation of the drug container.

5. The drug delivery device of claim 4 , further including an activator, and wherein displacement of the drug container is configured to cause the activator to displace a lockout pin of the needle insertion mechanism.

6. The drug delivery device of claim 5 , wherein the activator includes a ramped surface, wherein the ramped surface is configured to cause displacement of the lockout pin in a direction perpendicular to the longitudinal axis of the drug container.

7. The drug delivery device of claim 1 , wherein the housing includes an upper portion and a lower portion, the upper portion joined to the lower portion at a junction.

8. The drug delivery device of claim 7 , wherein the lower portion is capable of articulation with respect to the upper portion and further wherein the needle insertion mechanism is disposed substantially within the lower portion.

9. The drug delivery device of claim 1 , wherein the drive mechanism includes a retainer and a piston, the retainer being in an initial position in which it restricts translation of the piston and wherein actuation of the activation mechanism causes the retainer to release the piston.

10. The drug delivery device of claim 9 , wherein the drive mechanism further includes a drive mechanism housing, the retainer configured for rotation with respect to the drive mechanism housing and wherein actuation of the activation mechanism is configured to cause rotation of the retainer to release the piston.

11. The drug delivery device of claim 1 , further comprising an interlock, wherein in an initial configuration the interlock prevents actuation of the activation mechanism and wherein in a second configuration the interlock does not prevent actuation of the activation mechanism.

12. A drug delivery device comprising:
an activation mechanism;
a drive mechanism including a biasing member;
a drug container defining a longitudinal axis;
a pierceable seal disposed at a distal end of the drug container;
a plunger seal disposed in the drug container;
a fluid pathway connection including a piercing member;
a needle insertion mechanism including an insertion needle and an insertion biasing member;
a housing having a proximal end adjacent the activation mechanism and a distal end adjacent the needle insertion mechanism, wherein the drive mechanism, the fluid pathway connection, and the needle insertion mechanism are disposed within the housing; and
wherein the biasing member is configured to apply a force on the plunger seal in response to actuation of the activation mechanism, the force directed toward the distal end of the drug container, further wherein the force causes the drug container to translate in a distal direction and wherein the piercing member of the fluid pathway connection is configured to pierce the pierceable seal as a result of the translation of the drug container to open a fluid pathway from the drug container, through the piercing member and to the needle insertion mechanism,
wherein the needle insertion mechanism is disposed in the distal end of the housing, the insertion biasing member being retained in a compressed state at the distal end of the housing, wherein upon actuating the activation mechanism the insertion biasing member decompresses, thereby driving and causing the insertion needle to extend in the distal direction toward the distal end of the housing.

13. The drug delivery device of claim 12 , wherein the insertion biasing member is configured to cause the insertion needle to extend in the distal direction in response to the translation of the drug container.

14. The drug delivery device of claim 13 , further including an activator, and wherein displacement of the drug container is configured to cause the activator to displace a lockout pin of the needle insertion mechanism.

15. The drug delivery device of claim 14 , wherein the activator includes a ramped surface, wherein the ramped surface is configured to cause displacement of the lockout pin in a direction perpendicular to the longitudinal axis of the drug container.

16. The drug delivery device of claim 12 , wherein the housing includes an upper portion and a lower portion, the upper portion joined to the lower portion at a junction.

17. The drug delivery device of claim 16 , wherein the lower portion is capable of articulation with respect to the upper portion and further wherein the needle insertion mechanism is disposed substantially within the lower portion.

18. The drug delivery device of claim 12 , wherein the drive mechanism includes a retainer and a piston, the retainer being in an initial position in which it restricts translation of the piston and wherein actuation of the activation mechanism is configured to cause the retainer to release the piston.

19. The drug delivery device of claim 18 , wherein the drive mechanism further includes a drive mechanism housing, the retainer configured for rotation with respect to the drive mechanism housing and wherein actuation of the activation mechanism is configured to cause rotation of the retainer to release the piston.

20. The drug delivery device of claim 12 , further comprising an interlock, wherein in an initial configuration the interlock prevents actuation of the activation mechanism and wherein in a second c

Assignees

• Unl Holdings Llc

Inventors

• King Andrew N
• Hanson Ian B
• Bente Iv Paul F

Classifications

• A61M5/31535 Primary

  Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose · CPC title

• A61M2005/206

  With automatic needle insertion · CPC title

• A61M2005/247

  with fixed or steady piercing means, e.g. piercing under movement of ampoule · CPC title

• A61M2205/13

  with means for the detection of operative contact with patient, e.g. lip sensor · CPC title

• A61M2205/50

  with microprocessors or computers · CPC title