Flow sensor for cerebral fluidic device

Patent metadata

Field	Value
Publication number	US-11865284-B2
Application number	US-201816498597-A
Country	US
Kind code	B2
Filing date	Mar 29, 2018
Priority date	Mar 30, 2017
Publication date	Jan 9, 2024
Grant date	Jan 9, 2024

Abstract

The present disclosure provides a fluidic device including (a) a first channel including a first inlet and a first outlet, (b) a second channel including a second inlet and a second outlet, wherein the second inlet of the second channel is in fluid communication with the first outlet of the first channel, and (c) a sensor positioned between the first outlet and the second inlet, wherein the sensor includes a sensor configured to deflect in response to a flow between the first channel and the second channel.

First claim

We claim:

1. A system, comprising:
a fluidic device adapted to be positioned under a skin of a patient, the fluidic device comprising:
a first channel including a first inlet and a first outlet;
a second channel including a second inlet and a second outlet, wherein the second inlet of the second channel is in fluid communication with the first outlet of the first channel;
a sensor positioned between the first outlet and the second inlet, wherein the sensor comprises a membrane valve configured to deflect from a first position to a second position in response to a flow between the first channel and the second channel, and wherein the membrane valve includes one or more biocompatible reflective surfaces; and
an optical system adapted to be positioned under the skin of the patient, wherein the optical system includes a focusing lens configured to focus light from a light source onto the membrane valve, wherein the one or more biocompatible reflective surfaces of the membrane valve are configured to deflect light from the membrane valve to an imaging device, wherein the imaging device is configured to measure a light intensity of light reflected off of the one or more biocompatible reflective surfaces of the membrane valve, and wherein the light intensity measured by the imaging device has a first value when the membrane valve is in the first position, wherein the light intensity measured by the imaging device has a second value when the membrane valve is in the second position in response to the flow between the first channel and the second channel, and wherein the second value is greater than or less than the first value.

2. The system of claim 1 , wherein a longitudinal axis of the first outlet is substantially perpendicular to a longitudinal axis of the sensor, and wherein a flow at the first inlet of the first channel is substantially perpendicular to a flow across the sensor.

3. The system of claim 1 , wherein the one or more biocompatible reflective surfaces include a metal selected from a list including gold, Platinum, iridium, iridium oxide, Titanium, titanium alloys, and CoCr alloys.

4. The system of claim 1 , wherein the first inlet comprises a first nozzle.

5. The system of claim 1 , wherein the second outlet comprises a second nozzle.

6. The system of claim 1 , wherein the first channel is positioned in a first compartment, wherein the second channel is positioned in a second compartment, wherein the first compartment and the second compartment are coupled to one another such that the sensor is positioned between the first outlet of the first channel and the second inlet of the second channel.

7. The system of claim 6 , wherein the first compartment and the second compartment are removably coupled to one another.

8. The system of claim 6 , wherein a top surface of the second compartment includes an opening positioned above the sensor.

9. The system of claim 6 , wherein the first compartment and the second compartment are transparent.

10. The system of claim 1 , wherein the light source comprises an infrared light emitting diode, and wherein the imaging device comprises a charged coupled device (CCD) camera.

11. The system of claim 1 , wherein the first channel has a length between about 1 mm and about 20 mm and/or wherein the second channel has a length between about 1 mm and about 20 mm.

12. The system of claim 1 , wherein the first channel has a diameter between about 0.1 mm and about 3 mm, and/or wherein the second channel has a diameter between about 0.1 mm and about 3 mm.

13. The system of claim 1 , wherein the optical system is aligned to the sensor by an optical system holder.

14. The system of claim 1 , wherein the optical system comprises a prism mirror, an optical fiber, a ball lens positioned between the optical fiber and the prism mirror, and the focusing lens positioned between the optical fiber and the sensor, wherein the prism mirror is configured to deflect the light from the light source into the ball lens, wherein the ball lens is configured to focus the light into the optical fiber, wherein the optical fiber is configured to direct the light into the focusing lens, and wherein the focusing lens is configured to focus the light into the sensor.

15. The system of claim 14 , wherein the prism mirror has a dimension of about 1 mm by 1 mm to 5 mm by 5 mm, and/or wherein the ball lens has a diameter of about 1 mm to 5 mm, and/or wherein the optical fiber has a diameter of about 0.5 mm to 3 mm, and/or wherein the focusing lens has a diameter of about 2 mm to 6 mm.

16. The system of claim 1 , wherein the optical system comprises a prism mirror, an aperture, a hollow metal tube, and the focusing lens, wherein the prism mirror is configured to deflect the light from the light source into the aperture, wherein the aperture is configured to focus the light into the hollow metal tube, wherein the hollow metal tube is configured to direct the light into the focusing lens, and wherein the focusing lens is configured to focus the light into the sensor.

17. A method comprising:
positioning the system of claim 1 in a cerebral ventricle of a subject; and
detecting, via a deflection in the membrane valve, a flow rate of a liquid between the first channel and the second channel.

18. A non-transitory computer readable medium having stored thereon instructions, that when executed by one or more processors, cause an additive manufacturing machine to create the system of claim 1 .

19. A non-transitory computer readable medium having stored thereon instructions, that when executed by one or more processors, cause a system to perform operations comprising the steps of claim 17 .

20. The system of claim 1 , wherein the light source is adapted to be positioned above the skin of the patient, and wherein the imaging device is adapted to be positioned above the skin of the patient.

21. The system of claim 1 , wherein the membrane valve is configured to straighten when the membrane valve is in the second position.

Assignees

• Univ Connecticut
• Univ Yale

Inventors

• Hoshino Kazunori
• Jaiswal Davina
• Bao Mengdi
• Soler Garrett
• Garrett Ariane
• Grant Ryan
• Diluna Michael
• Zaveri Hitten

Classifications

• A61M27/006 Primary

  Cerebrospinal drainage; Accessories therefor, e.g. valves · CPC title

• B33Y80/00

  Products made by additive manufacturing · CPC title

• A61M2205/0216

  Materials providing elastic properties, e.g. for facilitating deformation and avoid breaking · CPC title

• A61M2205/0294

  Piezoelectric materials · CPC title

• A61M2205/3306

  Optical measuring means · CPC title