Parameter monitoring in medical treatment systems

Patent metadata

Field	Value
Publication number	US-11865243-B2
Application number	US-201716328443-A
Country	US
Kind code	B2
Filing date	Aug 30, 2017
Priority date	Aug 30, 2016
Publication date	Jan 9, 2024
Grant date	Jan 9, 2024

Abstract

A blood treatment system with pressure sensors may be configured to control blood flow to and from the patient and use readings of the pressure sensors to determine a change in a pressure drop across a flow restriction in the blood circuit to estimate a condition of the machine or the patient, or outputting data responsive to the estimation. Further embodiments employ measurement of pressure drop to detect abnormal viscosity or viscosity variations in order to detect possible infection.

First claim

What is claimed is:

1. A blood treatment system, comprising:
a machine comprising one or more pumps;
a blood circuit in engagement with the one or more pumps and having an inlet line for conveying blood to a patient and an outlet line for conveying the blood from the patient;
a treatment device configured to treat the blood and having a first port and a second port, the first port of the treatment device fluidly connected to the inlet line and the second port of the treatment device fluidly connected to the outlet line;
at least one of the inlet line or the outlet line having at least two pressure sensors positioned in it and a flow restriction located between said at least two pressure sensors, wherein all of the at least two pressure sensors are disposed upstream or downstream from a pump, among the one or more pumps, said pump being disposed in a same one of the inlet and outlet lines as the at least two pressure sensors; and
a controller configured to control the one or more pumps to convey blood to and from the patient, the controller further configured to use readings of the at least two pressure sensors to determine a change over time in a pressure drop across the flow restriction and to perform an action responsive to the change in the pressure drop, the action comprising at least one of:
generating a notification,
adjusting a blood flow rate in the blood circuit,
outputting an estimation of a condition of the machine or the patient, or
outputting data responsive to said estimation.

2. The blood treatment system of claim 1 , wherein the controller is configured to sample the pressure drop at multiple times over a period of time comprising a single treatment or multiple treatments and store data responsive thereto, wherein the change in the pressure drop is determined based on a trend over time of the stored data.

3. The blood treatment system of claim 2 , wherein the controller, responsively to said trend, generates a user notification, caution, or alarm, indicating that the trend is exceeding a limit.

4. The blood treatment system of claim 2 , wherein the inlet line comprises an arterial line and the outlet line comprises a venous line.

5. The blood treatment system of claim 2 , wherein the machine is adapted to control a balance of fluid in the patient by regulating a ratio of a total volume of fluid removed from the patient to a total volume of fluid supplied to the patient.

6. The blood treatment system of claim 5 , wherein the controller is programmed to estimate said ratio from said stored data.

7. The blood treatment system of claim 5 , wherein the controller is programmed to estimate said ratio independently of said stored data by using a signal indicating a pump speed, a fluid weight, a flow rate, or a fluid volume.

8. The blood treatment system of claim 2 , wherein the controller calculates a rate of fluid volume loss from said stored data.

9. The blood treatment system of claim 8 , wherein a relationship between viscosity and hematocrit is derived from historical data for the patient or for a class of patients into which the patient belongs.

10. The blood treatment system of claim 8 , wherein the controller stores a function of hematocrit versus viscosity-dependent parameter or hemoglobin versus viscosity, wherein the controller calculates hematocrit or hemoglobin responsively to said function and responsively to the stored data and wherein the controller outputs said hematocrit or hemoglobin.

11. The blood treatment system of claim 10 , wherein the function is a lookup table.

12. The blood treatment system of claim 2 , wherein the at least two pressure sensors include two pressure sensors upstream and two pressure sensors downstream of the flow restriction.

13. The blood treatment system of claim 2 , wherein the stored data is stored over multiple treatments for said patient to generate a historical record for said patient.

14. The blood treatment system of claim 13 , wherein the stored data over said multiple treatments indicates a trend over a course of therapy, said trend being stored over the multiple treatments for said patient to generate a historical record of trends for said patient.

15. The blood treatment system of claim 14 , wherein the trends are stored as an average or a curve fit to viscosity over time to provide a baseline trend, wherein the baseline trend is compared by said controller to a current trend, and a result of the comparison is output as a signal.

16. The blood treatment system of claim 2 , wherein the controller is configured to output said stored data to a treatment log.

17. The blood treatment system of claim 1 , wherein the at least two pressure sensors include pressure pods.

18. The blood treatment system of claim 1 , wherein the flow restriction in a flow path includes a physical structure in the flow path that causes a pressure drop between an inlet of the flow path and an outlet of the flow path.

19. The blood treatment system of claim 18 , wherein
the physical structure is a reduction of tubing diameter compared to the inlet and the outlet of the flow path.

20. The blood treatment system of claim 1 , further comprising a viscosity sensor, wherein the viscosity sensor draws a sample of blood from said blood circuit and applies the sample to a viscometer.

21. A blood treatment system, comprising:
a machine comprising one or more pumps;
a blood circuit in engagement with the one or more pumps and having a venous line for conveying blood to a patient and an arterial line for conveying the blood from the patient;
a treatment device configured to treat the blood and having an inlet port and an outlet port, the inlet port of the treatment device fluidly connected to the arterial line and the outlet port of the treatment device fluidly connected to the venous line;
at least two pressure sensors in the venous line or in the arterial line, with two pressure sensors of the at least two pressure sensors being in a same line and a flow restriction that causes a pressure drop from upstream to downstream of the flow restriction; and
a controller configured to control the one or more pumps to convey blood to and from the patient, the controller further configured to use readings of the at least two pressure sensors to determine a change over time in a pressure drop across the flow restriction and to perform an action responsive to the change in the pressure drop, the action comprising at least one of:
generating a notification,
adjusting a blood flow rate in the blood circuit,
outputting an estimation of a condition of the machine or the patient, or
outputting data responsive to said estimation,
wherein the controller is configured to sample the pressure drop at multiple times over a period of time comprising a single treatment or multiple treatments and store data responsive thereto, wherein the change in the pressure drop is determined based on a trend over time of the stored data.

22. The blood treatment system of claim 21 , wherein
the flow restriction in a flow path includes a reduction of tubing diameter compared to an inlet and an outlet of the flow path.

23. The blood treatment system of claim 21 , wherein
both of the two pressure sensors are disposed upstream or downstream from a pump, among the one or more pumps, said pump being disposed in the same line with the two pressure sensors.

Assignees

• Nxstage Medical Inc

Inventors

• Wyeth Mark T
• Mccarty Robert Paul
• Yantz Gregory
• Johnson James Ian
• Turk Jr Joseph E
• Brugger James M
• Burbank Jeffrey H

Classifications

• A61M1/3639 Primary

  Blood pressure control, pressure transducers specially adapted therefor · CPC title

• A61M1/1611

  Weight of the patient · CPC title

• A61M1/1621

  Constructional aspects thereof (semi-permeable membranes for separation processes characterised by their properties B01D69/00; semi permeable membranes characterised by their material B01D71/00) · CPC title

• A61M1/3623

  Means for actively controlling temperature of blood · CPC title

• A61M2205/3344

  Measuring or controlling pressure at the body treatment site · CPC title