Cromolyn metal complexes as enhanced pharmaceutical formulations and method of preparing the same

Patent metadata

Field	Value
Publication number	US-11865101-B2
Application number	US-202117307208-A
Country	US
Kind code	B2
Filing date	May 4, 2021
Priority date	May 4, 2020
Publication date	Jan 9, 2024
Grant date	Jan 9, 2024

Abstract

A series of pharmaceutical metal complexes (pMCs) were produced and characterized using the mast cell stabilizer, cromolyn, and bioactive metal ions (Zn +2 , Mg +2 , and Ca +2 ). Three novel pMCs, Cromolyn-Zn, Cromolyn-Mg, and Cromolyn-Ca were formed through reactions under controlled temperature and pH conditions. TGA demonstrated that these metal complexes showed an enhanced thermal stability due to the strong coordination with the ligand, cromolyn. PXRD data indicates a high degree of crystallinity as well as a unique packing arrangement for each pMCs. SEM analysis showed materials with well-defined morphologies while EDS presented elemental evidence for the unique composition of each pMCs. The crystal structure for these materials was elucidated through SCXRD, and a variety of binding modes and packing motifs were found within each respective metal complex. Only 2D structures were achieved under the conditions studied. Dissolution studies show high stability and slow degradation for the metal complexes, while a higher dissolution was observed for the drug compound in PBS. Neither CS nor the pMCs dissolved significantly in FaSSGF at 37° C.

First claim

The invention claimed is:

1. A pharmaceutical metal complex (pMC) comprising: a metal coordination complex of cromolyn coordinated with a metal selected from the group consisting of: Ca 2+ , Zn 2+ , and Mg 2+ .

2. The pMC according to claim 1 , wherein said metal coordination complex has a single crystal form characterized by major x-ray powder diffraction peaks at 2Θ angles of 6.02, 9.24, 11.46, 13.13, 14.04, 14.36, 14.81, 15.56, 25.66, 27.28, 27.9, and 28.28 when said metal is Ca 2+ .

3. The pMC according to claim 1 , wherein said metal coordination complex has a single crystal form characterized by major x-ray powder diffraction peaks at 2Θ angles of 5.56, 9.08, 12.94, 13.44, 15.52, 17.62, 18.22, 25.42, 26.06, 27.96, 28.38, and 28.64 when said metal is Zn 2+ .

4. The pMC according to claim 1 , wherein said metal coordination complex has a single crystal form characterized by major x-ray powder diffraction peaks at 2Θ angles of 5.42, 10.84, 14.22, 15.24, 17.84, 19.7, 24.3, 25.2, 26.28, 26.74, 27.2, and 30.8 when said metal is Mg 2+ .

5. The pMC of claim 2 , wherein the single crystal form is characterized by the X-ray powder diffraction pattern of FIG. 24 .

6. The pMC of claim 3 , wherein the single crystal form is characterized by the X-ray powder diffraction pattern of FIG. 22 .

7. The pMC of claim 4 , wherein the single crystal form is characterized by the X-ray powder diffraction pattern of FIG. 23 .

8. The pMC of claim 2 , wherein the single crystal form has a monoclinic unit cell with cell parameters: a=7.0293(3) Å, b=29.2917(7) Å, c=12.7862(4) Å and β=99.495(3)°.

9. The pMC of claim 3 , wherein the single crystal form has a monoclinic unit cell with cell parameters: a=31.90641(18) Å, b=6.99799(5) Å, c=22.92769(14) Å and β=95.6148 (6)°.

10. The pMC of claim 4 , wherein the single crystal form has a triclinic unit cell with cell parameters: a=7.34210(1) Å, b=10.37410(1) Å, c=16.8517(2) Å and β=98.9160 (1)°.

11. The pMC of claim 2 , wherein the single crystal form has monoclinic space group of P 21/n.

12. The pMC of claim 3 , wherein the single crystal form has monoclinic space group of C 2/c.

13. The pMC of claim 4 , wherein the single crystal form has triclinic space group of P 1 .

Assignees

• Lopez Mejias Vilmali
• Flores Bello Jeaninna P
• Rodriguez Rodriguez Israel
• Serrano Valcarcel Joyce Marie
• Univ Puerto Rico

Inventors

• Lopez-Mejias Vilmali
• Flores Bello Jeaninna P
• Rodriguez Rodriguez Israel
• Serrano Valcarcel Joyce Marie

Classifications

• A61K31/352 Primary

  condensed with carbocyclic rings, e.g. methantheline  {(cannabinoids A61K31/658)} · CPC title

• C07B2200/13

  Crystalline forms, e.g. polymorphs · CPC title

• A61K31/315 Primary

  Zinc compounds · CPC title