System, method and computer-accessible medium for accelerated, simultaneous quantitative and non-synthetic multi-contrast imaging

Patent metadata

Field	Value
Publication number	US-11864863-B2
Application number	US-202117475687-A
Country	US
Kind code	B2
Filing date	Sep 15, 2021
Priority date	Mar 15, 2019
Publication date	Jan 9, 2024
Grant date	Jan 9, 2024

Abstract

An exemplary system, method, and computer-accessible medium for generating a particular image which can be a quantitative image(s) of at least one section(s) of a patient(s) or (ii) a non-synthetic contrast image(s) of the section(s) of the patient(s), can include, for example, generating a first magnetic resonance (MR) signal and detecting the first MR signal to patient(s), receiving a second MR signal from the patient(s) that can be based on the first MR signal, and generating the particular image(s) based on the second MR signal. The first MR signal can be a configured MR signal. The configured MR signal can be configured for a particular contrast. The first MR signal can have a constant signal intensity. The first MR signal can be generated based on a degree of a plurality of flip angles that maintains the constant signal intensity. A degree of flip angles can be selected for the first MR signal based on the particular contrast.

First claim

What is claimed is:

1. A non-transitory computer-accessible medium having stored thereon computer-executable instructions for generating at least one particular image which is at least one of (i) at least one quantitative image of at least one section of at least one patient or (ii) at least one non-synthetic contrast image of the at least one section of the at least one patient, wherein, when a computer arrangement executes the instructions, the computer arrangement is configured to perform procedures comprising:
generating a first magnetic resonance (MR) signal and directing the first MR signal to the at least one patient;
receiving a second MR signal from the at least one patient that is based on the first MR signal;
generating the at least one particular image based on the second MR signal; and
generating MR information based on the second MR signal by:
pre-processing the second MR signal by compensating for a calibrated gradient delay,
scaling k-space of the second MR signal with a ratio of a field of view to a matrix size,
removing spikes in the second MR signal, and
weighting k-space data in the second MR signal with a predetermined density compensation factor,

wherein the at least one particular image is generated based on the MR information.

2. The computer-accessible medium of claim 1 , wherein the first MR signal is a configured MR signal.

3. The computer-accessible medium of claim 2 , wherein the MR signal is configured for a particular contrast.

4. The computer-accessible medium of claim 3 , wherein the first MR signal has a constant signal intensity.

5. The computer-accessible medium of claim 4 , wherein the computer arrangement is configured to generate the first MR signal based on a degree of a plurality of flip angles that maintains the constant signal intensity.

6. The computer-accessible medium of claim 3 , wherein the computer arrangement is configured to select a degree of flip angles for the first MR signal based on the particular contrast.

7. The computer-accessible medium of claim 6 , wherein the degree of the flip angles varies within a particular range.

8. The computer-accessible medium of claim 7 , wherein the degree of the flip angles varies about a mean value.

9. The computer-accessible medium of claim 8 , wherein the degree of the flip angles varies monotonously about the mean value.

10. The computer-accessible medium of claim 7 , wherein the degree of the flip angles varies pseudo randomly within the particular range.

11. The computer-accessible medium of claim 7 , wherein the particular range is about - −5+/−4 degrees, about 45+/−5 degrees, about 75+/−5 degrees, or about 75+/−5 degrees.

12. The computer-accessible medium of claim 3 , wherein the particular contrast includes at least one of T1, T2, proton density, water, fat, off resonance, diffusion, perfusion, or flow.

13. The computer-accessible medium of claim 1 , wherein the at least one non-synthetic contrast image is at least one non-synthetic multi-contrast image.

14. The computer-accessible medium of claim 1 , wherein the computer arrangement is configured to generate the at least one particular image using a reconstruction procedure.

15. The computer-accessible medium of claim 14 , wherein the reconstruction procedure is a sliding window reconstruction procedure.

16. The computer-accessible medium of claim 15 , wherein the reconstruction procedure includes converting the second MR signal to an image using a Non-Uniform Fast Fourier Transform.

17. The computer-accessible medium of claim 1 , wherein the computer arrangement is configured to generate the at least one quantitative image by vector-dot product matching L 2 -norm normalized dictionary entries with voxel signal evolutions in the second MR signal.

18. A method for generating at least one particular image which is at least one of (i) at least one quantitative image of at least one section of at least one patient or (ii) at least one non-synthetic contrast image of the at least one section of the at least one patient, comprising:
generating a first magnetic resonance (MR) signal and directing the first MR signal to the at least one patient;
receiving a second MR signal from the at least one patient that is based on the first MR signal;
generating the at least one particular image based on the second MR signal; and
generating MR information based on the second MR signal by:
pre-processing the second MR signal by compensating for a calibrated gradient delay,
scaling k-space of the second MR signal with a ratio of a field of view to a matrix size,
removing spikes in the second MR signal, and
weighting k-space data in the second MR signal with a predetermined density compensation factor,

wherein the at least one particular image is generated based on the MR information.

19. A system for generating at least one particular image which is at least one of (i) at least one quantitative image of at least one section of at least one patient or (ii) at least one non-synthetic contrast image of the at least one section of the at least one patient, comprising:
a computer hardware arrangement configured to:
generate a first magnetic resonance (MR) signal and directing the first MR signal to the at least one patient;
receive a second MR signal from the at least one patient that is based on the first MR signal; and

generate the at least one particular image based on the second MR signal; and
generate MR information based on the second MR signal by:
pre-processing the second MR signal by compensating for a calibrated gradient delay,
scaling k-space of the second MR signal with a ratio of a field of view to a matrix size,
removing spikes in the second MR signal, and
weighting k-space data in the second MR signal with a predetermined density compensation factor,

wherein the at least one particular image is generated based on the MR information.

Assignees

• Vaughan Jr John Thomas
• Geethanath Sairam
• Jambawalikar Sachin
• Poojar Pavan
• Qian Enlin
• Univ Columbia

Inventors

• Vaughan Jr John Thomas
• Geethanath Sairam
• Jambawalikar Sachin
• Poojar Pavan
• Qian Enlin

Classifications

• A61B5/055

  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging · CPC title

• A61B5/0042 Primary

  for the brain · CPC title

• G01R33/561

  by reduction of the scanning time, i.e. fast acquiring systems, e.g. using echo-planar pulse sequences · CPC title

• G01R33/5602

  by filtering or weighting based on different relaxation times within the sample, e.g. T1 weighting using an inversion pulse · CPC title

• A61B2576/026

  for the brain · CPC title