Compound for modulating DDAH and ADMA levels, as well as methods of using thereof to treat disease
US-11267780-B2 · Mar 8, 2022 · US
Compound for modulating DDAH and ADMA levels, as well as methods of using thereof to treat disease
US11858889B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11858889-B2 |
| Application number | US-202117565981-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 30, 2021 |
| Priority date | Apr 30, 2018 |
| Publication date | Jan 2, 2024 |
| Grant date | Jan 2, 2024 |
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- Title
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- Abstract
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Abstract
Official abstract text for this publication.
Disclosed are compounds that can modulate DDAH and the amount of asymmetric dimethylarginine (ADMA) in a subject. Also provided are pharmaceutical compositions comprising these compounds, as well as methods of using these compositions to treat and/or prevent diseases associated with elevated or low levels of DDAH and ADMA.
First claim
Opening claim text (preview).
What is claimed is: 1. A compound defined by the formula: or a pharmaceutically acceptable salt, wherein i) R 8 , R 9 , R 10 , R 11 , R 5 and R 4 are hydrogen and R 6 is methyl; or ii) R 8 , R 9 , R 10 , R 11 , R 6 , and R 5 are hydrogen and R 4 is methyl; or iii) R 8 , R 9 , R 10 , R 11 , R 6 , and R 5 are hydrogen and R 4 is chloro or floro; or iv) R 8 , R 9 , R 10 , R 11 , and R 6 are hydrogen, R 5 is methyl and R 4 is methoxy; or v) R 8 , R 9 , R 10 , R 11 , and R 5 are hydrogen, R 6 is methyl and R 4 is hydroxy; or vi) R 8 , R 9 , R 10 , R 11 , R 6 , and R 5 are hydrogen and R 4 is 2-(morpholin-4-yl)ethoxy; or vii) R 8 , R 9 , R 10 , R 11 , R 6 , and R 4 are hydrogen and R 5 is 2-(morpholin-4-yl)ethoxy; or viii) R 8 , R 9 , R 10 , R 11 , R 5 , and R 4 are hydrogen and R 6 is 2-(morpholin-4-yl)ethoxy. 2. The compound of claim 1 , wherein R 8 , R 9 , R 10 , R 11 , R 6 , and R 4 are hydrogen and R 5 is 2-(morpholin-4-yl)ethoxy. 3. A pharmaceutical composition comprising a compound of claim 1 . 4. A pharmaceutical composition comprising a compound of claim of claim 2 or a pharmaceutically acceptable salt thereof.
Assignees
Inventors
Classifications
- C07C65/19Primary
having unsaturation outside the aromatic ring · CPC title
- A61K31/192Primary
having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid {(cannabinoids A61K31/658)} · CPC title
a keto group being part of a condensed ring system · CPC title
containing rings other than six-membered aromatic rings · CPC title
Monocyclic acids with unsaturation outside the aromatic ring · CPC title
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Frequently asked questions
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- What does patent US11858889B2 cover?
- Disclosed are compounds that can modulate DDAH and the amount of asymmetric dimethylarginine (ADMA) in a subject. Also provided are pharmaceutical compositions comprising these compounds, as well as methods of using these compositions to treat and/or prevent diseases associated with elevated or low levels of DDAH and ADMA.
- Who is the assignee on this patent?
- Univ Indiana Trustees
- What technology area does this patent fall under?
- Primary CPC classification C07C65/19. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jan 02 2024 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).