Delivering tumor treating fields (TTFields) using implantable transducer arrays

Patent metadata

Field	Value
Publication number	US-11857782-B2
Application number	US-202318109539-A
Country	US
Kind code	B2
Filing date	Feb 14, 2023
Priority date	Feb 27, 2019
Publication date	Jan 2, 2024
Grant date	Jan 2, 2024

Abstract

Tumor treating fields (TTFields) can be delivered by implanting a plurality of sets of implantable electrode elements within a person's body. Temperature sensors positioned to measure the temperature at the electrode elements are also implanted, along with a circuit that collects temperature measurements from the temperature sensors. In some embodiments, an AC voltage generator configured to apply an AC voltage across the plurality of sets of electrode elements is also implanted within the person's body.

First claim

What is claimed is:

1. An apparatus for delivering tumor treating fields, the apparatus comprising:
a plurality of sets of electrode elements, wherein each of the sets of electrode elements is configured for implantation within a person's body;
a plurality of temperature sensors configured for implantation within the person's body and positioned to measure a temperature at each of the sets of electrode elements;
a plurality of multiplexors configured for implantation within the person's body, wherein each of the multiplexors is positioned to reduce a number of conductors that are required to obtain temperature measurements from a respective subset of the temperature sensors and to forward the obtained temperature measurements to an output; and
a circuit configured for implantation within the person's body configured for collecting the temperature measurements that have been forwarded by the multiplexors.

2. The apparatus of claim 1 , wherein each of the sets of electrode elements comprises a plurality of capacitively coupled electrode elements.

3. The apparatus of claim 1 , wherein each of the temperature sensors comprises a thermistor.

4. The apparatus of claim 1 , wherein the plurality of sets of electrode elements, the plurality of temperature sensors, the plurality of multiplexors, and the circuit are all implanted in the person's body.

5. The apparatus of claim 1 , wherein each of one or more electrode elements in each of the sets of electrode elements is associated with a respective one of the temperature sensors.

6. The apparatus of claim 1 , wherein each of the electrode elements is associated with a respective one of the temperature sensors.

7. The apparatus of claim 6 , wherein the circuit is configured to control a current that is applied to each individual electrode element based on signals from the plurality of temperature sensors so that the electrode elements do not overheat.

Assignees

• Novocure Gmbh

Inventors

• Wasserman Yoram
• Bomzon Zeev
• Hershkovich Hadas Sara
• Naveh Ariel
• Giladi Moshe
• Kirson Eilon
• Bar-Tal Golan
• VOLOSHIN-SELA Tali

Classifications

• A61N1/40

  Applying electric fields by inductive or capacitive coupling (microwave apparatus A61N5/00); {Applying radio-frequency signals} · CPC title

• A61N1/36002 Primary

  Cancer treatment, e.g. tumour · CPC title

• A61N1/05

  for implantation or insertion into the body, e.g. heart electrode (A61N1/06 takes precedence) · CPC title

• A61N1/3787

  from an external energy source · CPC title

• A61B18/14 Primary

  Probes or electrodes therefor · CPC title