Signal acquisition apparatus, signal acquisition system, and signal acquisition method

Patent metadata

Field	Value
Publication number	US-11842555-B2
Application number	US-202117642233-A
Country	US
Kind code	B2
Filing date	Mar 5, 2021
Priority date	Mar 5, 2020
Publication date	Dec 12, 2023
Grant date	Dec 12, 2023

Abstract

A signal acquisition apparatus includes a light source that irradiates a living tissue with light and a detector that acquires signals from light returned from the living tissue to generate output data on the basis of the signals. The detector includes circuitry that acquires the signals and characteristic data regarding the signals and generates the output data on the basis of the characteristic data. The circuitry is implemented in a single semiconductor chip. Further, the present technology also provides a signal acquisition system including the signal acquisition apparatus and an analysis unit configured to analyze output data output from the image acquisition apparatus.

First claim

The invention claimed is:

1. A signal acquisition apparatus comprising:
a light source configured to irradiate a biological sample with light; and
a single semiconductor chip that includes
a detector configured to detect light from the biological sample in a plurality of conditions, and
circuitry configured to apply a learned model to an output provided by the detector to determine characteristic data about the biological sample according to a condition, the condition being at least one of the plurality of conditions, the condition comprising detection of the light from the biological sample at a plurality of different light wavelengths.

2. The signal acquisition apparatus according to claim 1 , wherein
the condition further comprising detection of the light from the biological sample from at least one of a plurality of positions or a plurality of angles.

3. The signal acquisition apparatus according to claim 1 , wherein
the condition further comprising detection by the detector of the light from the biological sample at different times.

4. The signal acquisition apparatus according to claim 1 , wherein
the semiconductor chip is configured to receive the learned model from an external processing apparatus.

5. The signal acquisition apparatus according to claim 1 , wherein
the circuitry of the single semiconductor chip is configured to train the learned model.

6. The signal acquisition apparatus according to claim 1 , wherein
the detector includes an imaging element, and the output provided by the detector includes a pixel signal from the imaging element.

7. The signal acquisition apparatus according to claim 1 , wherein
the detector includes an imaging element, and
the circuitry is further configured to determine the characteristic data based on focus state information of the imaging element.

8. The signal acquisition apparatus according to claim 7 , wherein
the focus state information includes at least one of a Z position at a time of imaging, an amount of blur of the light received by the imaging element, or an amount of deviation of the Z position from an in-focus position.

9. The signal acquisition apparatus according to claim 7 , wherein
the circuitry is configured to determine whether to execute focus adjustment based on the focus state information.

10. The signal acquisition apparatus according to claim 9 , wherein
the circuitry is configured to execute the focus adjustment of the imaging element prior to the imaging element capturing an image of the biological sample by the imaging element at a position after the focus adjustment has been executed.

11. The signal acquisition apparatus according to claim 10 , wherein
the circuitry is configured to generate the characteristic data from a signal provided by the imaging device at the position after the focus adjustment has been executed.

12. The signal acquisition apparatus according to claim 1 , wherein
the detector includes an imaging element, and
the circuitry is configured to determine, based on the characteristic data, whether to execute focus adjustment on the imaging element.

13. The signal acquisition apparatus according to claim 12 , wherein
the circuitry is configured to control, based on the characteristic data, an imaging operation performed by the imagining element of the biological sample at a position where the focus adjustment has already been executed.

14. The signal acquisition apparatus according to claim 1 , wherein
the detector includes an imaging element,
the circuitry is configured to acquire signals from the imagining element from the light from the biological sample at a plurality of positions in an optical axis direction, and
the circuitry is further configured to acquire from a set of the signals acquired at the plurality of positions, signal correlation information or focus state information.

15. The signal acquisition apparatus according to claim 14 , wherein
the focus state information includes a focus detection value.

16. The signal acquisition apparatus according to claim 14 , wherein
the circuitry is configured to generate an output image based on a plurality of pieces of the focus state information and control the imaging element to output the output image.

17. The signal acquisition apparatus according to claim 16 , wherein
the output image includes an image generated from a signal acquired at a certain Z position in the set of signals.

18. The signal acquisition apparatus according to claim 15 , wherein
an output image from the imaging element includes an image generated from a most focused signal in the set of signals.

19. The signal acquisition apparatus according to claim 14 , wherein
an output image from the imaging element includes an image generated from signals acquired at a plurality of Z positions in the set of signals.

20. The signal acquisition apparatus according to claim 14 , wherein the circuitry is also configured to apply the learned model to image data from the imaging element to generate an output image of the biological sample.

21. The signal acquisition apparatus according to claim 14 , wherein
the circuitry is configured to
divide respective images based on the set of signals acquired at the plurality of positions into a plurality of regions,
acquire focus state information regarding each of the plurality of regions, and
connect images of regions in focus to generate an output image.

22. The signal acquisition apparatus according to claim 1 , wherein
the circuitry is configured to acquire spectrum effective region information based on previously obtained output from the detector.

23. The signal acquisition apparatus according to claim 22 , wherein
the circuitry is configured to acquire the spectrum effective region information by using the learned model.

24. The signal acquisition apparatus according to claim 22 , wherein
the circuitry is configured to control a readout region of the detector based on the spectrum effective region information.

25. The signal acquisition apparatus according to claim 1 , wherein
the circuitry is configured to acquire the output from the detector from the light from the biological sample through an objective lens.

26. The signal acquisition apparatus according to claim 1 , wherein
the biological sample includes a bio-derived tissue sample.

27. A sensor comprising:
a detector configured to detect light from a biological sample in a plurality of conditions and generate output data based on the detected light, and
circuitry configured to apply a learned model to the output data provided by the detector to determine characteristic data about the biological sample according to a condition, the condition being at least one of the plurality of conditions, the condition comprising detection of the light from the biological sample at a plurality of different light wavelengths.

28. A signal acquisition system comprising:
a signal acquisition apparatus including
a light source configured to irradiate a biological sample with light, and
a single semiconductor chip that includes
a detector configured to produce a signal from light returned from the biological sample irradiated with the light by the light source in a plurality of conditions, and
circuitry configured to
apply a learned model to the signal provided by the detector to determine cha

Assignees

• Sony Group Corp

Inventors

• Yamane Kenji
• Mizutani Yoichi
• Hayashi Nobuhiro
• Tatsuta Hirokazu

Classifications

• G06V20/695 Primary

  Preprocessing, e.g. image segmentation · CPC title

• H04N23/67

  Focus control based on electronic image sensor signals · CPC title

• H04N23/695

  Control of camera direction for changing a field of view, e.g. pan, tilt or based on tracking of objects · CPC title

• G01N21/31 Primary

  Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry {(G01N21/72 takes precedence)} · CPC title

• G01N21/6458

  Fluorescence microscopy (fluorescence microscopes per se G02B21/0076 and G02B21/16) · CPC title