Process of manufacture of annexin v
US-2024116982-A1 · Apr 11, 2024 · US
Cation exchange resins
US11840554B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11840554-B2 |
| Application number | US-202117172156-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 10, 2021 |
| Priority date | Aug 12, 2016 |
| Publication date | Dec 12, 2023 |
| Grant date | Dec 12, 2023 |
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- Title
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Abstract
Official abstract text for this publication.
In some embodiments, the present invention provides a method of purifying a protein of interest with a reduced level of aggregation formation in cation exchange (CEX) chromatography, comprising: (a) providing a mixture comprising the protein of interest and one or more contaminants; (b) loading the mixture onto a CEX resin coupled with arginine; and (c) eluting the protein of interest from the resin, thereby purifying the protein of interest with a reduced level of aggregation formation in CEX chromatography.
First claim
Opening claim text (preview).
We claim: 1. A cation exchange (CEX) resin chemically coupled with arginine for use in chromatography. 2. The CEX resin of claim 1 , wherein the CEX resin is selected from agarose, cellulose, dextran, chitosan, poly(methacrylate), acrylic polymers, and poly(styrene-divinyl-benzene). 3. The CEX resin of claim 1 , wherein the CEX resin is prepared using a cation exchange ligand selected from sulfonate, carboxylic, carboxymethyl sulfonic acid, sulfoisobutyl, sulfoethyl, carboxyl, sulphopropyl, sulphonyl, sulphoxyethyl and orthophosphate. 4. The CEX resin of claim 1 , wherein the CEX resin coupled with arginine is an arginine-sulphopropyl (Arg-SP) functionalized resin.
Assignees
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Classifications
- C07K1/18Primary
Ion-exchange chromatography · CPC title
in the weakly acidic form · CPC title
obtained by reactions only involving unsaturated carbon-to-carbon bonds · CPC title
Cellulose or wood; Derivatives thereof · CPC title
Affinity chromatography or related techniques based upon selective absorption processes · CPC title
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- What does patent US11840554B2 cover?
- In some embodiments, the present invention provides a method of purifying a protein of interest with a reduced level of aggregation formation in cation exchange (CEX) chromatography, comprising: (a) providing a mixture comprising the protein of interest and one or more contaminants; (b) loading the mixture onto a CEX resin coupled with arginine; and (c) eluting the protein of interest from the …
- Who is the assignee on this patent?
- Bristol Myers Squibb Co
- What technology area does this patent fall under?
- Primary CPC classification C07K1/18. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Dec 12 2023 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).