Stable hydrogel compositions including additives
US-2017273886-A1 · Sep 28, 2017 · US
Hyaluronic acid-collagen matrices for dermal filling and volumizing applications
US11833269B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11833269-B2 |
| Application number | US-201916595481-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 8, 2019 |
| Priority date | Sep 6, 2011 |
| Publication date | Dec 5, 2023 |
| Grant date | Dec 5, 2023 |
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- Title
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- Abstract
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Abstract
Official abstract text for this publication.
Hydrogels comprising a macromolecular matrix and water may be used for aesthetic fillers, for example, dermal fillers. The macromolecular matrix may include a crosslinked combination of hyaluronic acid and collagen.
First claim
Opening claim text (preview).
What is claimed is: 1. A hydrogel composition comprising: (i) about 16 mg/ml to about 24 mg/ml of a hyaluronic acid, and (ii) about 3 mg/ml to about 6 mg/ml of a collagen, wherein the weight ratio of the hyaluronic acid to the collagen is from 3:1 to 7:1; wherein the hyaluronic acid is crosslinked with the collagen via a plurality of crosslink units, wherein the hyaluronic acid is crosslinked with the collagen via a water-soluble carbodiimide, wherein at least a portion of the crosslink units comprise an amide bond, and wherein the composition has a storage modulus value of between about 850 Pa and about 5,000 Pa. 2. The composition of claim 1 , wherein the hydrogel has a storage modulus value of between about 1,000 Pa and about 5,000 Pa. 3. The composition of claim 1 , wherein the collagen is collagen type I, collagen type III, or a combination thereof. 4. The composition of claim 3 , wherein the collagen is collagen type I. 5. The composition of claim 3 , wherein the collagen is derived from a human or porcine source. 6. The composition of claim 1 , wherein the hyaluronic acid has a molecular weight of about 1,000,000 Da to about 5,000,000 Da. 7. The composition of claim 1 , wherein the hydrogel has a hyaluronic acid concentration of about 18 mg/ml or about 20 mg/ml. 8. The composition of claim 1 , wherein the hydrogel has a collagen concentration of about 3 mg/ml, about 4 mg/ml or about 5 mg/ml. 9. The composition of claim 1 , wherein the composition is injectable. 10. An injectable hydrogel product comprising the composition of claim 1 . 11. A method of augmenting a soft tissue in a subject in need thereof, the method comprising administering to the subject the composition of claim 1 .
Assignees
Inventors
Classifications
- A61L27/24Primary
Collagen · CPC title
Gels · CPC title
Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof · CPC title
Mixtures of macromolecular compounds · CPC title
characterised by the function or physical properties of the final product, where no specific conditions are defined to achieve this (A61L27/3687, A61L27/3691 take precedence) · CPC title
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Frequently asked questions
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- What does patent US11833269B2 cover?
- Hydrogels comprising a macromolecular matrix and water may be used for aesthetic fillers, for example, dermal fillers. The macromolecular matrix may include a crosslinked combination of hyaluronic acid and collagen.
- Who is the assignee on this patent?
- Allergan Inc
- What technology area does this patent fall under?
- Primary CPC classification A61L27/24. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Dec 05 2023 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 3 related publications on this page (citations in our corpus or others sharing the same primary CPC).