System and method for image segmentation and digital analysis for clinical trial scoring in skin disease
US-11244456-B2 · Feb 8, 2022 · US
US11832958B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11832958-B2 |
| Application number | US-202218080331-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 13, 2022 |
| Priority date | Dec 4, 2018 |
| Publication date | Dec 5, 2023 |
| Grant date | Dec 5, 2023 |
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There is shown and described a deep learning based system and method for skin diagnostics as well as testing metrics that show that such a deep learning based system outperforms human experts on the task of apparent skin diagnostics. Also shown and described is a system and method of monitoring a skin treatment regime using a deep learning based system and method for skin diagnostics.
Opening claim text (preview).
What we claim is: 1. A skin diagnostic device comprising: a memory configured to store and provide a convolutional neural network (CNN) configured to classify pixels of an image to determine a plurality (N) of respective skin sign diagnoses for each of a plurality (N) of respective skin signs wherein the CNN comprises a deep neural network for image classification configured to generate the N respective skin sign diagnoses and wherein the CNN is trained using skin sign data for each of the N respective skin signs; and at least one processor coupled to the memory and configured to receive the image and process the image using the CNN to generate the N respective skin sign diagnoses, wherein the CNN comprises: an encoder phase for image classification and configured to encode features to a final encoder phase feature net; and a decoder phase configured to receive the final encoder phase feature net for decoding by a plurality (N) of respective parallel skin sign branches to generate each of the N respective skin sign diagnoses. 2. The skin diagnostic device according to claim 1 , wherein the decoder phase includes a global pooling operation to process the final encoder phase feature net to provide to each of the N respective parallel skin sign branches. 3. The skin diagnostic device according to claim 1 , wherein the CNN is further configured to classify the pixels to determine an ethnicity vector and the CNN is trained using skin sign data for each of the N respective skin signs and a plurality of ethnicities. 4. The skin diagnostics device according to claim 3 , wherein the decoder phase comprises a further parallel branch for ethnicity to generate the ethnicity vector. 5. The skin diagnostic device according to claim 1 , wherein each branch of the N respective parallel skin sign branches comprises in succession: a first fully connected layer followed, a first activation layer, a second fully connected layer, a second activation layer and a final activation layer to output a final value comprising one of the N respective skin sign diagnoses and the ethnicity vector. 6. The skin diagnostic device according to claim 5 , wherein the final activation layer is defined in accordance with a function of equation (1) for an input score x received from the second activation layer: LeakyClamp ( x ) = { x if x ∈ [ a , b ] α ( x - a ) + a if x < a α ( x - b ) + b if x > b ( 1 ) where α is a slope, a is a lower bound and b is an upper bound of a respective score range for each the N respective skin sign diagnoses. 7. The skin diagnostic device according to claim 4 : wherein the CNN is trained using multiple samples in the form (x i , y i ), with x i being the i-th training image and y i being a corresponding vector of ground truth skin sign diagnoses; and wherein the CNN is trained to minimize a loss function for each respective branch of the N parallel skin sign branches and the further parallel branch for ethnicity. 8. The skin diagnostic device according to claim 7 , wherein the CNN is further trained to minimize a loss function L, comprising a L2 loss function for each of the N respective skin sign branches in a weighted combination with a standard cross-entropy classification loss L ethnicity for the further parallel branch for ethnicity, according to equation (3): L=L 2+λ L ethnicity (3) where λ controls a balance between a score regression and ethnicity classification losses. 9. The skin diagnostic device according to claim 1 , wherein the memory stores a face and landmark detector to pre-process the image and wherein the at least one processor is configured to generate a normalized image from the image using the face and landmark detector and use the normalized image when using the CNN. 10. The skin diagnostic device according to claim 1 , wherein the CNN comprises a pre-trained network for image classification which is adapted to generate the N respective skin sign diagnoses such that: the fully connected layers of the pre-trained network are removed; and N respective groups of layers are defined to decode a same feature net for each of the N respective skin sign diagnoses in parallel. 11. The skin diagnostic device according to claim 1 , configured as one of: a computing device for personal use comprising a mobile dev
Auto-encoder networks; Encoder-decoder networks · CPC title
Learning methods · CPC title
Convolutional networks [CNN, ConvNet] · CPC title
Transfer learning · CPC title
Supervised learning · CPC title
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