Electrically enhanced retrieval of material from vessel lumens

Patent metadata

Field	Value
Publication number	US-11832836-B2
Application number	US-202217647319-A
Country	US
Kind code	B2
Filing date	Jan 6, 2022
Priority date	Dec 11, 2017
Publication date	Dec 5, 2023
Grant date	Dec 5, 2023

Abstract

Retrieval of material from vessel lumens can be improved by electrically enhancing attachment of the material to the removal device. The removal device can have a core assembly that includes a hypotube coupled to a first electrical terminal and a pushwire coupled to a second electrical terminal, the pushwire extending through the hypotube lumen. An insulating layer separates the hypotube and the pushwire, and an interventional element is coupled to a distal end of the pushwire. The interventional element can be disposed adjacent to a thrombus. An electrical signal is delivered to the interventional element to promote adhesion of the thrombus to the interventional element. The electrical signal can optionally be a periodic waveform, and the total energy delivered can be between 0.75-24,000 mJ and the peak current delivered via the electrical signal can be between 0.5-5 mA.

First claim

We claim:

1. A system for removing a thrombus, the system comprising:
a delivery electrode comprising an interventional element configured to be disposed proximate to or adjacent to a thrombus within a blood vessel, the interventional element comprising a self-expandable mesh;
a core assembly having a distal end portion coupled to the interventional element,
the core assembly comprising:
an electrically conductive pushwire;
a conductive hypotube surrounding the pushwire along at least a portion of its length, the hypotube having a cut pattern along at least a portion of its length; and
an electrically insulative material disposed radially between the pushwire and the hypotube;

and
a current generator having a first terminal in electrical communication with the pushwire and a second terminal electrically coupled to the hypotube, the current generator configured to deliver an electrical signal to the interventional element for a predetermined time period,
wherein the peak current delivered via the electrical signal is between 0.5-5 mA, and
wherein the predetermined time period is no more than 5 minutes.

2. The system of claim 1 , wherein the current generator comprises a power source and a processor coupled to a memory, the memory storing the instructions for causing the power source to deliver the electrical signal to the interventional element.

3. The system of claim 1 , wherein the current generator comprises a power source and drive circuitry configured to deliver the electrical signal to the interventional element.

4. The system of claim 1 , wherein the predetermined time period is no more than 2 minutes.

5. The system of claim 1 , wherein the total energy delivered via the electrical signal over the predetermined time period is between 120-24,000 mJ.

6. The system of claim 1 , wherein the total energy delivered via the electrical signal over the predetermined time period is between 120-5000 mJ.

7. The system of claim 1 , wherein the total charge delivered via the electrical signal over the predetermined time period is between 30-1200 mC.

8. The system of claim 1 , wherein the total charge delivered via the electrical signal over the predetermined time period is between 120-160 mC.

9. The system of claim 1 , wherein the electrical signal comprises a square waveform.

10. The system of claim 1 , wherein the interventional element comprises an electrically conductive self-expandable device.

11. The system of claim 1 , wherein the interventional element comprises a stent retriever.

12. The system of claim 1 , wherein the electrical signal comprises a periodic waveform or a constant direct current.

13. A system for removing a thrombus, the system comprising:
a first electrode comprising an interventional element, the interventional element comprising a self-expandable mesh;
a core assembly having a distal end portion coupled to the interventional element and including a second electrode, the core assembly comprising:
an elongate shaft;
a tubular member surrounding the elongate shaft along at least a portion of its length, the tubular member having a cut pattern along at least a portion of its length; and
an insulative material disposed radially between the elongate shaft and the tubular member; and

a current generator having a first terminal in electrical communication with the first electrode and a second terminal electrically coupled to the second electrode, the current generator configured to deliver an electrical signal to the interventional element for a predetermined time period,
wherein the peak current delivered via the electrical signal is between 0.5-5 mA, and
wherein the predetermined time period is no more than 5 minutes.

14. The system of claim 13 , wherein the electrical signal comprises a monopolar square wave.

15. The system of claim 13 , wherein the interventional element comprises a tubular thrombectomy device.

16. The system of claim 13 , wherein the predetermined time period is no more than 2 minutes.

17. The system of claim 13 , wherein the total energy delivered via the electrical signal over the predetermined time period is between 120-5000 mJ.

18. The system of claim 13 , wherein the total charge delivered via the electrical signal over the predetermined time period is between 120-160 mC.

19. The system of claim 1 , wherein the first terminal is electrically coupled to the pushwire and the second terminal is electrically coupled to the hypotube.

20. The system of claim 13 , wherein the first terminal is electrically coupled to the elongate shaft and the second terminal is electrically coupled to the tubular member.

Assignees

• Covidien Lp

Inventors

• Girdhar Gaurav
• Nguyen Hoai
• Huynh Andyanhdzung
• Nageswaran Ashok
• Andrews Christopher

Classifications

• A61B17/22031 Primary

  Gripping instruments, e.g. forceps, for removing or smashing calculi (A61B17/221 takes precedence) · CPC title

• A61B17/221 Primary

  Gripping devices in the form of loops or baskets {for gripping calculi or similar types of obstructions (surgical snare instruments A61B17/32056)} · CPC title

• A61B18/00

  Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body (eye surgery A61F9/007; ear surgery A61F11/00) · CPC title

• A61F2/95

  Instruments specially adapted for placement or removal of stents or stent-grafts · CPC title

• A61B2017/00017

  Electrical control of surgical instruments · CPC title