Biodegradable piezoelectric ultrasonic transducer system

Patent metadata

Field	Value
Publication number	US-11826495-B2
Application number	US-202016806885-A
Country	US
Kind code	B2
Filing date	Mar 2, 2020
Priority date	Mar 1, 2019
Publication date	Nov 28, 2023
Grant date	Nov 28, 2023

Abstract

A biodegradable and biocompatible piezoelectric nanofiber platform for medical implant applications, including a highly sensitive, wireless, biodegradable force sensor for the monitoring of physiological pressures, and a biodegradable ultrasonic transducer for the delivery of therapeutics or pharmaceuticals across the blood-brain barrier.

First claim

What is claimed is:

1. A biodegradable ultrasonic transducer comprising:
a first biodegradable metal electrode;
a second biodegradable metal electrode;
a biodegradable piezoelectric material positioned between the first biodegradable metal electrode and the second biodegradable metal electrode;
a first link comprised of a biodegradable material, the first link coupled to the first biodegradable metal electrode and a coil;
a second link comprised of a biodegradable material, the second link coupled to the second biodegradable metal electrode and the coil; and
an encapsulation layer covering the first biodegradable metal electrode, the second biodegradable metal electrode, the biodegradable piezoelectric material, the first link, and the second link,
wherein the biodegradable ultrasonic transducer is configured for implantation near a target and to receive power through the first link and the second link to generate ultrasound waves for delivery to the target.

2. The transducer of claim 1 , wherein the biodegradable piezoelectric material comprises poly (L-lactic acid) (PLLA).

3. The transducer of claim 1 , wherein the encapsulation layer comprises a biodegradable medical polymer.

4. The transducer of claim 3 , wherein the biodegradable medical polymer is poly(lactic acid) (PLA).

5. The transducer of claim 1 , wherein the biodegradable piezoelectric material has a piezoelectric constant greater than 12 pC/N.

6. The transducer of claim 1 , wherein the biodegradable piezoelectric material has a perimeter greater than a perimeter of the first biodegradable metal electrode or the second biodegradable metal electrode.

7. A biodegradable ultrasonic transducer system comprising:
a biodegradable ultrasonic transducer of claim 1 ; and
a coil coupled to the first biodegradable metal electrode and the second biodegradable metal electrode.

8. The system of claim 7 , wherein the coil is coupled to the first biodegradable metal electrode with a first wire and to the second biodegradable metal electrode with a second wire.

9. The system of claim 8 , wherein the first wire and the second wire comprise Molybdenum (Mo).

10. The system of claim 8 , wherein the coil is covered with the encapsulation layer.

11. The system of claim 9 , wherein the coil is covered with the encapsulation layer.

Assignees

• Univ Connecticut

Inventors

• Nguyen Thanh Duc
• Le Thinh
• Curry Eli

Classifications

• A61L31/148 Primary

  Materials at least partially resorbable by the body · CPC title

• A61L31/022

  Metals or alloys · CPC title

• A61L31/06

  obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds {(A61L31/041 takes precedence)} · CPC title

• A61L31/10

  Macromolecular materials · CPC title

• A61M37/0092

  using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis · CPC title