Lithium disilicate glass-ceramic compositions and methods thereof

Patent metadata

Field	Value
Publication number	US-11814649-B2
Application number	US-201816163013-A
Country	US
Kind code	B2
Filing date	Oct 17, 2018
Priority date	May 27, 2016
Publication date	Nov 14, 2023
Grant date	Nov 14, 2023

Abstract

A bioactive glass-ceramic composition as defined herein. Also disclosed are methods of making and using the disclosed compositions.

First claim

What is claimed is:

1. A bioactive composition, comprising:
a glass-ceramic composition comprising
a first crystalline phase comprising lithium disilicate, and
a second crystalline phase that is apatite, wollastonite, fluorapatite, cristobalite, β-quartz, lithiophosphate, or a combination thereof; and

at least one live osteoblast cell,
wherein contacting the bioactive composition with a liquid medium produces proliferation of the osteoblast cell on a surface of the bioactive composition, and
wherein the glass-ceramic composition comprises a source of:
50 to 75 wt % SiO 2 ,
1 to 5 wt % Al 2 O 3 ,
1 to 8 wt % P 2 O 5 ,
2 to 10 wt % CaO,
5 to 20 wt % Li 2 O,
0.5 to 5 wt % Na 2 O,
0.5 to 8 wt % ZrO 2 ,
0.1 to 10 wt % B 2 O 3 , and
0.1 to 1.0 wt % F − , based on a 100 wt % total of the composition.

2. The bioactive composition of claim 1 , wherein the glass-ceramic composition comprises a source of:
50 to 60 wt % SiO 2 ,
1 to 3 wt % Al 2 O 3 ,
2 to 6 wt % P 2 O 5 ,
4 to 8 wt % CaO,
7.5 to 12.5 wt % Li 2 O,
0.5 to 2 wt % Na 2 O,
1 to 4 wt % ZrO 2 ,
0.1 to 10 wt % B 2 O 3 , and
0.2 to 0.8 wt % F − , based on a 100 wt % total of the composition.

3. The bioactive composition of claim 1 , further comprising at least one compressive stress layer on the surface of the bioactive composition.

4. The bioactive composition of claim 1 , further comprising a strength of from 200 MPa to 500 MPa.

5. The bioactive composition of any claim 1 , further comprising a fracture toughness of from 1.4 to 2.0 MPa·m 1/2 .

6. A bioactive composition, comprising:
a glass-ceramic composition comprising
a first crystalline phase comprising lithium disilicate, and
a second crystalline phase comprising wollastonite, cristobalite, β-quartz, lithiophosphate, or a combination thereof; and

at least one live osteoblast cell;
wherein contacting the bioactive composition with a liquid medium produces proliferation of the osteoblast cell on a surface of the bioactive composition, and
wherein the glass-ceramic composition comprises a source of:
50 to 75 wt % SiO 2 ,
1 to 5 wt % Al 2 O 3 ,
1 to 8 wt % P 2 O 5 ,
2 to 10 wt % CaO,
5 to 20 wt % Li 2 O,
0.5 to 5 wt % Na 2 O,
0.5 to 8 wt % ZrO 2 ,
0.1 to 10 wt % B 2 O 3 , and
0.1 to 1.0 wt % F − , based on a 100 wt % total of the composition.

7. The bioactive composition of claim 6 , wherein the glass-ceramic composition comprises a source of:
50 to 60 wt % SiO 2 ,
1 to 3 wt % Al 2 O 3 ,
2 to 6 wt % P 2 O 5 ,
4 to 8 wt % CaO,
7.5 to 12.5 wt % Li 2 O,
0.5 to 2 wt % Na 2 O,
1 to 4 wt % ZrO 2 ,
0.1 to 10 wt % B 2 O 3 , and
0.2 to 0.8 wt % F − , based on a 100 wt % total of the composition.

8. The bioactive composition of claim 6 , further comprising at least one compressive stress layer on the surface of the bioactive composition.

9. The bioactive composition of claim 6 , further comprising a strength of from 200 MPa to 500 MPa.

10. The bioactive composition of any claim 6 , further comprising a fracture toughness of from 1.4 to 2.0 MPa·m 1/2 .

11. A method of culturing osteoblast cells, comprising:
contacting the bioactive composition of claim 1 with the liquid medium to produce a proliferation of the at least one osteoblast cell on the first crystalline phase and on the second crystalline phase.

12. The method of claim 11 , wherein contacting with the liquid medium produces a proliferation of the at least one osteoblast cell in the liquid medium.

13. The method of claim 12 , wherein the liquid medium comprises a simulated body fluid composition.

14. A method of culturing osteoblast cells, comprising:
contacting the bioactive composition of claim 6 with the liquid medium to produce a proliferation of the at least one osteoblast cell on the first crystalline phase and on the second crystalline phase.

Assignees

• Corning Inc

Inventors

• Deng Huayun
• Fu Qiang
• Mauro John Christopher

Classifications

• C03B32/02

  Thermal crystallisation, e.g. for crystallising glass bodies into glass-ceramic articles {(C03B27/012 takes precedence)} · CPC title

• C03C10/0009 Primary

  containing silica as main constituent · CPC title

• C12N5/0654 Primary

  Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth · CPC title

• A61K35/32

  Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane · CPC title

• C03C3/097 Primary

  containing phosphorus, niobium or tantalum · CPC title