Heterocyclic compounds as monoacylglycerol lipase inhibitors

Patent metadata

Field	Value
Publication number	US-11802133-B2
Application number	US-202217749496-A
Country	US
Kind code	B2
Filing date	May 20, 2022
Priority date	Aug 13, 2018
Publication date	Oct 31, 2023
Grant date	Oct 31, 2023

Abstract

The invention provides new heterocyclic compounds having the general formula (I)wherein A, L, X, m, n, R1 and R2 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

First claim

The invention claimed is:

1. A compound, wherein the compound is:

or is a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 , wherein the compound is:

3. A pharmaceutical composition comprising the compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a therapeutically inert carrier.

4. A pharmaceutical composition comprising the compound of claim 2 , and a therapeutically inert carrier.

5. A method of treating a neurodegenerative disease in a mammal in need thereof, comprising administering to the mammal an effective amount of the compound of claim 1 , or a pharmaceutically acceptable salt thereof.

6. The method of claim 5 , wherein the neurodegenerative disease is multiple sclerosis, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, traumatic brain injury, neurotoxicity, stroke, or epilepsy.

7. The method of claim 5 , wherein the neurodegenerative disease is multiple sclerosis, Alzheimer's disease, or Parkinson's disease.

8. The method of claim 5 , wherein the mammal is a human.

9. The method of claim 6 , wherein the mammal is a human.

10. The method of claim 7 , wherein the mammal is a human.

Assignees

• Hoffmann La Roche

Inventors

• Bell Charles
• Benz Joerg
• Gobbi Luca
• Grether Uwe
• Groebke Zbinden Katrin
• Hornsperger Benoit
• Kocer Buelent
• Kroll Carsten
• Kuhn Bernd
• Lutz Marius Daniel Rinaldo
• O'Hara Fionn
• Richter Hans
• Ritter Martin
• Rombach Didier
• Kuratli Martin

Classifications

• C07D498/04 Primary

  Ortho-condensed systems · CPC title

• C07D519/00

  Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00 · CPC title

• A61K31/5365 Primary

  ortho- or peri-condensed with heterocyclic ring systems · CPC title

• A61P25/00

  Drugs for disorders of the nervous system · CPC title

• A61P25/28

  for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia · CPC title