Composition for improving the solubility of poorly soluble substances, use thereof and complex formulation containing thereof

Patent metadata

Field	Value
Publication number	US-11801310-B2
Application number	US-201816232601-A
Country	US
Kind code	B2
Filing date	Dec 26, 2018
Priority date	Dec 26, 2017
Publication date	Oct 31, 2023
Grant date	Oct 31, 2023

Abstract

A composition for improving the solubility of poorly soluble substances is provided. The composition includes about 40-99.5% by weight of cyclodextrin and/or derivatives thereof; about 0.05-10% by weight of at least one water-soluble polymer; and about 0.05-60% by weight of at least one water-soluble stabilizer.

First claim

What is claimed is:

1. A composition for improving the solubility of poorly soluble substances, comprising:
40-99.5% by weight of cyclodextrin and/or a derivative thereof;
0.05-10% by weight of at least one water-soluble polymer; and
0.05-20% by weight of at least one water-soluble stabilizer, wherein the at least one water-soluble stabilizer comprises adenine or guanine.

2. The composition for improving the solubility of poorly soluble substances as claimed in claim 1 , wherein the cyclodextrin comprises α-cyclodextrin, β-cyclodextrin, γ-cyclodextrin, δ-cyclodextrin or a combination thereof.

3. The composition for improving the solubility of poorly soluble substances as claimed in claim 1 , wherein the derivative of cyclodextrin comprises hydroxypropyl modified cyclodextrin, succinyl modified cyclodextrin, methyl modified cyclodextrin or a combination thereof.

4. The composition for improving the solubility of poorly soluble substances as claimed in claim 3 , wherein the hydroxypropyl modified cyclodextrin comprises hydroxypropyl-γ-cyclodextrin (hydroxypropyl-γ-CD).

5. The composition for improving the solubility of poorly soluble substances as claimed in claim 1 , wherein the at least one water-soluble polymer comprises hydroxypropyl methyl cellulose (HPMC), hydroxypropyl cellulose, carboxymethyl cellulose (CMC), polyvinylpyrrolidone, (PVP), polyvinyl alcohol, poly(ethylene glycol)-poly(propylene glycol)-poly(ethylene glycol) (PEG-PPG-PEG (ABA)) triblock copolymer or a combination thereof.

Assignees

• Ind Tech Res Inst

Inventors

• Huang Wen-Chia
• Wang Yen-Jen
• Cheng Felice
• Chen Chia-Ching
• Yin Shao-Chan
• Pan Chien-Lin
• Hu Tsan-Lin
• Lin Meng-Nan
• Huang Kuo-Kuei
• Lu Maggie
• Liu Chih-Peng

Classifications

• A61K47/6951 Primary

  using cyclodextrin (cyclodextrins used as simple excipients A61K47/40) · CPC title

• A61K9/0019 Primary

  Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00) · CPC title

• A61K9/0048

  Eye, e.g. artificial tears · CPC title

• A61K9/0053

  Mouth and digestive tract, i.e. intraoral and peroral administration · CPC title

• A61K9/08

  Solutions {(composition of solutions A61K47/00)} · CPC title