Manufacturing method for granule

Patent metadata

Field	Value
Publication number	US-11801222-B2
Application number	US-201916598299-A
Country	US
Kind code	B2
Filing date	Oct 10, 2019
Priority date	Apr 14, 2017
Publication date	Oct 31, 2023
Grant date	Oct 31, 2023

Abstract

A method for producing granules of a uniform size includes preparing an organic member solution, uniformly dispersing an inorganic member in the organic member solution at a weight ratio of 1 to 10 based on an organic member to form an organic-inorganic composite solution, spraying the organic-inorganic composite solution in an electrostatic charge manner, and polymerizing the sprayed organic-inorganic composite solution to form a hydrogel phase. The granules having a uniform size may be mass-produced in a short time and may be produced at a high yield. The method may be applied to a variety of fields, such as a pharmaceutical field, a medical field, a cosmetics field, and a food field and may replace a conventional spray drying method.

First claim

The invention claimed is:

1. A method for manufacturing granules, the method comprising:
preparing an organic member solution;
uniformly dispersing an inorganic member in the organic member solution at a weight ratio of 1 to 10 based on an organic member to form an organic-inorganic composite solution, the uniformly dispersing including,
dispersing the inorganic member with a rotation and revolution mixer to form an organic-inorganic composite solution, and
stirring the organic-inorganic composite solution with an ultrasonic mixer;
spraying the organic-inorganic composite solution in an electrostatic charge manner after the uniformly dispersing; and
polymerizing the organic member contained in the sprayed organic-inorganic composite solution to form granules having a hydrogel phase,
wherein an average diameter of the granules is between 100 to 2000 μm, and
each diameter of the granules falls in a range of −20% to +20% to the average size of granules,
wherein the organic member comprises at least one organic matter among alginate, collagen, gelatin, chitosan, cellulose, and hyaluronate,
wherein the inorganic member comprises at least one among hydroxy apatite (HA), dicalcium phosphate (DCP), tricalcium phosphate (TCP), tetracalcium phosphate (TTCP), and octacalcium phosphate (OCP).

2. The method of claim 1 ,
wherein the weight ratio of the inorganic member dispersed in the organic member solution to the organic member is 5 to 10.

3. The method of claim 1 ,
wherein the polymerizing is performed by dropping the sprayed organic-inorganic composite solution to a polymerization-inducing solution.

4. The method of claim 1 ,
wherein the inorganic member comprises a functional member.

5. The method of claim 1 , further comprising:
supporting a functional member or cells in the organic-inorganic composite solution.

6. The method of claim 1 ,
wherein a concentration of the organic member solution is 0.5-5 wt %.

7. The method of claim 1 ,
wherein a size of the inorganic member is 20 nm to 10 μm.

8. The method of claim 1 ,
wherein the dispersing is performed in a range where a temperature of the organic-inorganic composite solution does not exceed 40° C.

9. The method of claim 1 ,
wherein the spraying the organic-inorganic composite solution in an electrostatic charge manner is performed by using a micro-granule coater, and
the micro-granule coater has a spray nozzle size in a range of 50-1,000 μm, a voltage in a range of 500-2,500 V, a pressure in a range of 100-1,500 mbar, and a vibration frequency in a range of 100-6,000 Hz.

10. The method of claim 1 ,
wherein the formed hydrogel phase does not comprise a dispersant.

11. The method of claim 1 , further comprising:
washing and drying the formed hydrogel phase; and
sintering the washed and dried hydrogel phase.

12. The method of claim 9 ,
wherein the average diameter of the granules is controlled according to change in the spray nozzle size, pneumatic condition and frequency of the micro-granule coater.

13. The method of claim 1 ,
the polymerizing is performed by any one among ion crosslinking, chemical crosslinking, and photo crosslinking.

14. The method of claim 13 ,
wherein the ion crosslinking uses at least one polymerization-inducing material among calcium chloride (CaCl 2 ), calcium sulfate (CaSO 4 ), and calcium carbonate (CaCO 3 ).

15. The method of claim 11 ,
wherein the sintering is performed at a temperature range of 1000-1300° C. to remove the organic member.

16. The method of claim 11 ,
wherein a size and porosity of the granules are controlled according to content of the inorganic member to the organic member.

17. The method of claim 11 ,
wherein the manufactured granules are granulated particles comprising calcium oxide (CaO) and content of the calcium oxide is 1 to 10 mass %.

Assignees

• Korea Inst Mach & Materials
• Korea Institute Materials Science

Inventors

• Yun Hui Suk
• Park Honghyun

Classifications

• A61K9/1694 Primary

  resulting in granules or microspheres of the matrix type containing more than 5% of excipient · CPC title

• A61L27/12

  Phosphorus-containing materials, e.g. apatite · CPC title

• A61L27/425

  of phosphorus containing material, e.g. apatite · CPC title

• A61K9/1652 Primary

  Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin (homeopathic globules A61K9/1623) · CPC title

• C04B35/03

  based on magnesium oxide, calcium oxide or oxide mixtures derived from dolomite · CPC title