Film-forming composition containing surfactant or surfactant and salt as whitening agent

Patent metadata

Field	Value
Publication number	US-11801205-B2
Application number	US-201917253103-A
Country	US
Kind code	B2
Filing date	Jul 3, 2019
Priority date	Jul 4, 2018
Publication date	Oct 31, 2023
Grant date	Oct 31, 2023

Abstract

[Problem] Providing a whitened capsule and a whitened film without using any white pigment such as titanium dioxide.
[Solution] Provided is a film, a capsule, and a film forming composition, characterized by comprising: a film-forming polymer; and a whitening agent including either a surfactant or both a surfactant and a salt, and characterized in that the surfactant is selected from a fatty acid ester of polyhydric alcohol, a polyethylene glycol, a polypropylene glycol, a polyalkylene oxide derivative, an alkyl sulfate ester salt, and a saponin.

First claim

The invention claimed is:

1. A single layer white film, comprising:
a single film-forming polymer as a base material of the single layer white film, wherein the single film-forming polymer is either gelatin or pullulan; and
a whitening agent that includes either a surfactant or both a surfactant and a water-soluble salt,
wherein the surfactant is a fatty acid ester of polyhydric alcohol, polyethylene glycol, polypropylene glycol, polyalkylene oxide derivative, alkyl sulfate ester salt, and/or a saponin; and
wherein the single layer white film is free from a white-color pigment.

2. The single layer white film according to claim 1 ,
wherein the fatty acid ester of polyhydric alcohol is a sucrose fatty acid ester, sorbitan fatty acid ester, glycerin fatty acid ester, or polyoxysorbitan fatty acid ester;
the polyalkylene oxide derivative is a polyoxyethylene polyoxypropylene glycol, polyoxyethylene alkyl ether, or polyoxyethylene fatty acid ester; and
the saponin is either a triterpenoid saponin or steroid saponin.

3. The single layer white film according to claim 1 ,
wherein the surfactant is polyoxyethylene polyoxypropylene glycol, sucrose monolaurate ester, sucrose palmitate ester, sorbitan monolaurate ester, Polysorbate 80, sodium lauryl sulfate, quillaja saponin, ginseng saponin, soybean saponin, sophora saponin, tea seed saponin, beet saponin, yucca saponin, or glycyrrhizin.

4. The single layer white film according to claim 1 ,
wherein whiteness of the single layer white film is adjusted by a total amount of the surfactant within a range from 0.5 parts by weight to 30 parts by weight while an amount, in dry weight, of the film-forming polymer is defined as 100 parts by weight.

5. The single layer white film according to claim 1 ,
wherein whiteness of the single layer white film is adjusted by a total amount of the surfactant within a range from 0.7 parts by weight to 30 parts by weight while an amount, in dry weight, of the film-forming polymer is defined as 100 parts by weight.

6. The single layer white film according to claim 1 ,
wherein whiteness of the single layer white film is adjusted by a total amount of the surfactant within a range from 1.0 part by weight to 30 parts by weight while an amount, in dry weight, of the film-forming polymer is defined as 100 parts by weight.

7. The single layer white film according to claim 1 ,
wherein whiteness of the single layer white film is adjusted by a total amount of the surfactant within a range from 0.5 parts by weight to 15 parts by weight while an amount, in dry weight, of the film-forming polymer is defined as 100 parts by weight.

8. The single layer white film according to claim 1 ,
wherein the water-soluble salt to be added is a sodium salt and/or a potassium salt and/or an ammonium salt.

9. The single layer white film according to claim 1 ,
wherein the water-soluble salt to be added to the film-forming polymer is one or more salts selected from sodium malate, sodium succinate, sodium citrate, sodium polyphosphate, sodium bicarbonate, dipotassium hydrogenphosphate, disodium hydrogenphosphate, sodium dihydrogenphosphate, potassium carbonate, potassium dihydrogenphosphate, and sodium pyrophosphate dehydrate,
the whiteness of the single layer white film is changed by the total amount of the water-soluble salt within a range from 0.5 parts by weight to 30 parts by weight, while an amount, in dry weight, of the film-forming polymer is defined as 100 parts by weight.

10. The single layer white film according to claim 1 , further comprising a dye or a pigment to provide the single layer white film with a color other than white.

11. A capsule that is made of the single layer white film according to claim 1 and that is suitable for oral delivery.

12. The capsule according to claim 11 , wherein the capsule is filled with a drug, a cosmetic or a health food product.

13. The capsule according to claim 11 ,
wherein a combination of the film-forming polymer and the surfactant is a combination of:
gelatin and sucrose monolaurate ester;
gelatin and polyoxyethylene polyoxypropylene glycol;
gelatin and the saponin; or
pullulan and polyoxyethylene polyoxypropylene glycol.

14. A film forming composition for forming the single layer white film according to claim 1 , the film forming composition comprising:
the single film-forming polymer dissolved in water, and
the whitening agent.

15. A method of manufacturing a single layer white film or a capsule suitable for oral delivery, the single layer white film and the capsule being white and free from a white-color pigment, the method comprising:
providing gelatin or pullulan as a film-forming polymer to provide a base material of the single layer white film or capsule; and
providing, as a whitening agent, either a surfactant or both a surfactant and a water-soluble salt;
combining the film-forming polymer and the whitening agent to provide a film-forming composition; and
forming the single layer white film or the capsule from the film-forming composition;
wherein the surfactant is a fatty acid ester of polyhydric alcohol, polyethylene glycol, polypropylene glycol, polyalkylene oxide derivative, an alkyl sulfate ester salt, or a saponin.

16. The capsule according to claim 13 , wherein the saponin is quillaja saponin, ginseng saponin, soybean saponin, sophora saponin, tea seed saponin, beet saponin, yucca saponin, or glycyrrhizin.

17. A white film comprising:
a film-forming polymer that is a cellulose derivative; and
a whitening agent that includes either a surfactant or both a surfactant and a water-soluble salt, wherein the surfactant is an alkyl sulfate ester salt and/or a saponin; and
wherein the white film is free from a white-color pigment.

18. The film according to claim 17 , wherein the cellulose derivative is hydroxypropyl methylcellulose (HPMC).

19. The film according to claim 17 , wherein the surfactant is sodium lauryl sulfate, quillaja saponin, ginseng saponin, soybean saponin, sophora saponin, tea seed saponin, beet saponin, yucca saponin, or glycyrrhizin.

20. The film according to claim 17 , wherein whiteness of the film is adjusted by a total amount of the surfactant within a range from 0.5 parts by weight to 30 parts by weight while an amount, in dry weight, of the film-forming polymer is defined as 100 parts by weight.

21. The film according to claim 17 , wherein whiteness of the film is adjusted by a total amount of the surfactant within a range from 0.7 parts by weight to 30 parts by weight while an amount, in dry weight, of the film-forming polymer is defined as 100 parts by weight.

22. The film according to claim 17 , wherein whiteness of the film is adjusted by a total amount of the surfactant within a range from 1.0 part by weight to 30 parts by weight while an amount, in dry weight, of the film-forming polymer is defined as 100 parts by weight.

23. The film according to claim 17 , wherein whiteness of the film is adjusted by a total amount of the surfactant within a range from 0.5 parts by weight to 15 parts by weight while an amount, in dry weight, of the film-forming polymer is defined as 100 parts by weight.

24. The film according to claim 17 , wherein the water-soluble salt to be added is a sodium salt and/or a potassium salt and/or an ammonium salt.

25. The film according to claim 17 , wherein the water-soluble salt to be added to the film-forming polymer is one

Assignees

• Capsugel Belgium Nv

Inventors

• Sato Kaori
• Takubo Takahisa
• Doi Hitomi

Classifications

• A61K2800/92

  Oral administration · CPC title

• A61K2800/594

  Mixtures of polymers · CPC title

• A61K2800/43

  Pigments; Dyes · CPC title

• A61K2800/26

  Optical properties · CPC title

• A61K2800/10

  General cosmetic use · CPC title