System and method for collecting and isolating radiosotopes

Patent metadata

Field	Value
Publication number	US-11798702-B2
Application number	US-201916554048-A
Country	US
Kind code	B2
Filing date	Aug 28, 2019
Priority date	Sep 6, 2018
Publication date	Oct 24, 2023
Grant date	Oct 24, 2023

Abstract

A method for obtaining 225AC from 225Ra having the steps of assembling a column having an inorganic stationary phase; priming the column to immobilize 226Ra 225Ra and natural decay products therefrom; immobilizing the 226Ra, 225Ra, 224Ra, and natural decay products therefrom onto a stationary phase within the column; and eluting the column containing the 225Ra with an aqueous sulfate solution to obtain a milking effluent that contains 225AC. Also provided is a method for obtaining pure 225AC from its isotope parents, the method comprising assembling a column having a stationary phase comprising an inorganic material; priming the column with the isotope parents to immobilize 225Ac, and natural decay products of 225AC; immobilizing the 225Ac, and natural decay products therefrom onto the stationary phase within the column 226Ra, 225Ra, 224Ra; and eluting the column containing the 225AC to obtain an effluent that contains the isotope parents.

First claim

The invention claimed is:

1. A method for obtaining 225 Ac from its isotope parents, the method comprising:
a) assembling a column having a stationary phase comprising an inorganic material;
b) priming the column with the isotope parents;
c) immobilizing the 225 Ac, and natural decay products therefrom onto the stationary phase within the column; and
d) eluting the column containing the 225 Ac to obtain an effluent that contains the isotope parents wherein the priming step further comprises eluting an aqueous solution containing free hydroxide ions until the effluent of the column is basic.

2. The method as recited in claim 1 wherein the eluting step comprises contacting the column with a mineral acid selected from the group consisting of hydrochloric acid, nitric acid, sulfuric acid, perchloric acid, and combinations thereof.

3. The method as recited in claim 1 wherein the 225 Ac, immobilized on the column remains on the column after step d).

4. The method as recited in claim 1 wherein the inorganic material is a compound selected from the group consisting of alumina, zirconate, titanate, niobate, and combinations thereof.

5. A method for obtaining 225 Ac from its isotope parents, the method comprising:
a) assembling a column having a stationary phase comprising an inorganic material;
b) priming the column with the isotope parents;
c) immobilizing the 225 Ac, and natural decay products therefrom onto the stationary phase within the column; and
d) eluting the column containing the 225 Ac to obtain an effluent that contains the isotope parents wherein the immobilizing step further comprises:
e) eluting an aqueous solution containing 226 Ra, 225 Ra, 224 Ra, and natural decay products therefrom through the column;
f) eluting a dilute solution of H 2 SO 4 through the column; and
g) eluting water through the column until the effluent has neutral pH.

6. The method as recited in claim 5 wherein the eluting step comprises contacting the column with a mineral acid selected from the group consisting of hydrochloric acid, nitric acid, sulfuric acid, perchloric acid, and combinations thereof.

7. The method as recited in claim 5 wherein the 225 Ac, immobilized on the column remains on the column after step d).

8. The method as recited in claim 5 wherein the inorganic material is a compound selected from the group consisting of alumina, zirconate, titanate, niobate, and combinations thereof.

Assignees

• Uchicago Argonne Llc

Inventors

• Brown Michael A
• Gelis Artem
• Rotsch David
• Nolen Jr Jerry A
• Youker Amanda J

Classifications

• G21G1/12 Primary

  by electromagnetic irradiation, e.g. with gamma or X-rays (applications of radiation G21H5/00; irradiation devices G21K5/00) · CPC title

• B01D15/322

  Normal bonded phase · CPC title

• B01D15/363

  Anion-exchange · CPC title

• B01J20/0211

  Compounds of Ti, Zr, Hf · CPC title

• B01J41/05

  in the strongly basic form · CPC title