Purification process for the preparation of non-carrier added copper-64

Patent metadata

Field	Value
Publication number	US-11798701-B2
Application number	US-202217993186-A
Country	US
Kind code	B2
Filing date	Nov 23, 2022
Priority date	Sep 3, 2020
Publication date	Oct 24, 2023
Grant date	Oct 24, 2023

Abstract

Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.

First claim

What is claimed is:

1. A composition for use as a radioactive precursor comprising from 4 Ci to 15 Ci of copper-64 ( 64 Cu), wherein the composition has a total content of trace metals of less than about 6 parts per million (ppm), the trace metals being cobalt, copper, gold, iron, lead, mercury, nickel, and zinc, and wherein the composition comprises chemical and radionuclidic purities suitable for positron emission tomography (PET).

2. The composition of claim 1 , wherein the composition has a total content of trace metals of less than about 3 parts per million (ppm), the trace metals being cobalt, copper, gold, iron, lead, mercury, nickel, and zinc.

3. The composition of claim 1 , wherein the composition has a total content of trace metals of 0 ppm Au, 0 ppm Hg, <0.02 ppm Co, <0.2 ppm Fe, <0.4 ppm Pb, <0.5 ppm Ni, <0.6 ppm Cu, and <1.5 ppm Zn.

4. The composition of claim 1 , wherein the composition comprises a solution of hydrochloric acid (HCl) having a molarity of about 0.001 M to about 3 M.

5. The composition of claim 1 , wherein the 64 Cu exists as [ 64 Cu]CuCl 2 .

6. The composition of claim 5 , wherein the composition further comprises a chelating agent or a bifunctional chelating agent in which the 64 Cu is coordinated therein, and the chelating agent or the bifunctional chelating agent is a macrocyclic compound, a bridged macrocyclic compound, a bicyclic compound, or an acyclic compound.

7. The composition of claim 6 , wherein the bifunctional chelating agent is DOTA.

8. A non-carrier added composition for use as a radioactive precursor of a patient dose comprising from 4 Ci to 15 Ci of copper-64 ( 64 Cu), wherein the composition has a total content of trace metals of less than about 6 part per million (ppm), the trace metals being cobalt, copper, gold, iron, lead, mercury, nickel, and zinc, and wherein the composition comprises chemical and radionuclidic purities suitable for positron emission tomography (PET).

9. The composition of claim 8 , wherein the composition has a total content of trace metals of less than about 5 parts per million (ppm), the trace metals being cobalt, copper, gold, iron, lead, mercury, nickel, and zinc.

10. The composition of claim 8 , wherein the composition has a total content of trace metals of less than about 3 parts per million (ppm), the trace metals being cobalt, copper, gold, iron, lead, mercury, nickel, and zinc.

11. The composition of claim 8 , wherein the composition has a total content of trace metals of 0 ppm Au, 0 ppm Hg, <0.02 ppm Co, <0.2 ppm Fe, <0.4 ppm Pb, <0.5 ppm Ni, <0.6 ppm Cu, and <1.5 ppm Zn.

12. The composition of claim 8 , wherein the composition comprises a solution of hydrochloric acid (HCl) having a molarity of about 0.001 M to about 3 M.

13. The composition of claim 8 , wherein the 64 Cu exists as [ 64 Cu]CuCl2.

14. The composition of claim 13 , wherein the composition further comprises a chelating agent or a bifunctional chelating agent in which the 64 Cu is coordinated therein, and the chelating agent or the bifunctional chelating agent is a macrocyclic compound, a bridged macrocyclic compound, a bicyclic compound, or an acyclic compound.

15. The composition of claim 14 , wherein the bifunctional chelating agent is DOTA.

Assignees

• Curium Us Llc

Inventors

• Pipes David
• Radford Lauren
• Uhland William
• Regna Brian
• Brunkhorst Craig

Classifications

• G21G1/001 Primary

  Recovery of specific isotopes from irradiated targets · CPC title

• A61K51/0482

  chelates from cyclic ligands, e.g. DOTA · CPC title

• C01G3/003

  Preparation involving a liquid-liquid extraction, an adsorption or an ion-exchange · CPC title

• G21G1/10

  by bombardment with electrically charged particles (irradiation devices G21K5/00) · CPC title

• G21G4/08

  specially adapted for medical application (radiation therapy using radioactive sources A61N5/10) · CPC title