Inhibitors of RAC1 and uses thereof for treating cancers

Patent metadata

Field	Value
Publication number	US-11795144-B2
Application number	US-201816619311-A
Country	US
Kind code	B2
Filing date	Jun 6, 2018
Priority date	Jun 6, 2017
Publication date	Oct 24, 2023
Grant date	Oct 24, 2023

Abstract

The present invention concerns a compound having the following formula (I):

wherein:
A is in particular —N(R′ a )—C(═O)—R, R′ a being H or a (C 1 -C 6 )alkyl group, and R being preferably a group having the following formula (II):

X is in particular chosen from the group consisting of: —SO 2 —N(R′ b )—, R′ b being H or a (C 1 -C 6 )alkyl group, —N(R″ b )—SO 2 —, R″ b being H or a (C 1 -C 6 )alkyl group, —CO—NH—, and —NH—CO—,

for use for the treatment of cancers, such as metastatic cancers.

First claim

The invention claimed is:

1. A method for the treatment of cancer, comprising administering to a mammal in need thereof a therapeutically effective amount of a compound having the following formula (VII):

wherein:
p is an integer from 1 to 3 inclusive;
X′ is chosen from the group consisting of: —S—, —NH—, —NR d —, —CH 2 —, —SO 2 —, and —SO—, R d being H or a (C 1 -C 6 )alkyl group;
R 5 is a (C 1 -C 6 )alkyl group; and
the R 4 groups, identical or different, are chosen from the (C 1 -C 6 )alkyl groups.

2. The method of claim 1 , wherein X′ is —CH 2 —or —S—.

3. The method of claim 1 , wherein the compound of formula (VII) is the following compound:

4. (Allowed) The method of claim 1 , wherein the cancer is breast cancer.

Assignees

• Inst Nat Sante Rech Med
• Centre Nat Rech Scient
• Univ Nantes
• Chu Nantes

Inventors

• Sauzeau Vincent
• Loirand Gervaise
• Lebreton Jacques
• Tessier Arnaud
• Quemener Agnès

Classifications

• C07C311/29 Primary

  having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring · CPC title

• A61P35/00

  Antineoplastic agents · CPC title

• C07C311/21 Primary

  having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring · CPC title

• C07C311/44

  having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring · CPC title

• A61P35/04

  specific for metastasis · CPC title