Treatment of lung cancer using a combination of an anti-pd-1 antibody and another anti-cancer agent
US-2017158776-A1 · Jun 8, 2017 · US
US11793945B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11793945-B2 |
| Application number | US-202217846902-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 22, 2022 |
| Priority date | Jun 22, 2021 |
| Publication date | Oct 24, 2023 |
| Grant date | Oct 24, 2023 |
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A droplet delivery device includes a housing with a mouthpiece port or outlet from a nasal device for releasing fluid droplets, a fluid reservoir, and an ejector bracket having a membrane positioned between a mesh with a plurality of openings and a vibrating member that is coupled to an electronic transducer, such as an ultrasonic transducer. The transducer vibrates the vibrating member which causes the membrane to push fluid supplied by the reservoir through the mesh to generate droplets in an ejected stream released through the outlet.
Opening claim text (preview).
What is claimed is: 1. A droplet delivery device comprising: a container assembly with a mouthpiece port; a reservoir disposed within or in fluid communication with the container assembly and configured to supply a volume of fluid; an ejector bracket in fluid communication with the reservoir, the ejector bracket including a mesh with a membrane operably coupled to a vibrating member that is coupled to an electronic transducer with the membrane between the vibrating member and the mesh, wherein the reservoir includes a self-sealing mating mechanism configured to couple to a fluid release mating mechanism of the ejector bracket, and wherein the mesh includes a plurality of openings formed through the mesh's thickness, and wherein the transducer is coupled to a power source and is operable to oscillate the vibrating member and the membrane and generate an ejected stream of droplets through the mesh; and an ejection channel within the container assembly configured to direct the ejected stream of droplets from the mesh to an outlet. 2. A droplet delivery device comprising: a container assembly with a mouthpiece port; a reservoir disposed within or in fluid communication with the container assembly and configured to supply a volume of fluid; an ejector bracket in fluid communication with the reservoir, the ejector bracket including a mesh with a membrane operably coupled to a vibrating member that is coupled to an electronic transducer with the membrane between the vibrating member and the mesh, wherein the membrane includes a slanted upper surface configured to contact the fluid supplied from the reservoir, and wherein the mesh includes a plurality of openings formed through the mesh's thickness, and wherein the transducer is coupled to a power source and is operable to oscillate the vibrating member and the membrane and generate an ejected stream of droplets through the mesh; and an ejection channel within the container assembly configured to direct the ejected stream of droplets from the mesh to an outlet. 3. A droplet delivery device comprising: a container assembly with a mouthpiece port; a reservoir disposed within or in fluid communication with the container assembly and configured to supply a volume of fluid; an ejector bracket in fluid communication with the reservoir, the ejector bracket including a mesh with a membrane operably coupled to a vibrating member that is coupled to an electronic transducer with the membrane between the vibrating member and the mesh, wherein the vibrating member includes a ring-shaped beveled tip, and wherein the mesh includes a plurality of openings formed through the mesh's thickness, and wherein the transducer is coupled to a power source and is operable to oscillate the vibrating member and the membrane and generate an ejected stream of droplets through the mesh; and an ejection channel within the container assembly configured to direct the ejected stream of droplets from the mesh to an outlet. 4. A droplet delivery device comprising: a container assembly with a mouthpiece port; a reservoir disposed within or in fluid communication with the container assembly and configured to supply a volume of fluid; an ejector bracket in fluid communication with the reservoir, the ejector bracket including a mesh with a membrane operably coupled to a vibrating member that is coupled to an electronic transducer with the membrane between the vibrating member and the mesh, wherein the vibrating member includes a ring-shaped non-beveled tip, and wherein the mesh includes a plurality of openings formed through the mesh's thickness, and wherein the transducer is coupled to a power source and is operable to oscillate the vibrating member and the membrane and generate an ejected stream of droplets through the mesh; and an ejection channel within the container assembly configured to direct the ejected stream of droplets from the mesh to an outlet. 5. A droplet delivery device comprising: a container assembly with a mouthpiece port; a reservoir disposed within or in fluid communication with the container assembly and configured to supply a volume of fluid; an ejector bracket in fluid communication with the reservoir, the ejector bracket including a mesh with a membrane operably coupled to a vibrating member that is coupled to an electronic transducer with the membrane between the vibrating member and the mesh, wherein the mesh has a bottom surface in a non-parallel configuration with an upper surface of the membrane, and wherein the mesh includes a plurality of openings formed through the mesh's thickness, and wherein the transducer is coupled to a power source and is operable to oscillate the vibrating member and the membrane and generate an ejected stream of droplets through the mesh; and an ejection channel within the container assembly configured to direct the ejected stream of droplets from the mesh to an outlet. 6. A droplet delivery device comprising: a container assembly with a mouthpiece port; a reservoir disposed within or in fluid communication with the container assembly and configured to supply a volume of fluid; an ejector bracket in fluid communication with the reservoir, the ejector bracket including a mesh with a membrane operably coupled to a vibrating member that is coupled to an electronic transducer with the membrane between the vibrating member and the mesh, wherein the mesh has a bottom surface in a non-parallel configuration with an upper surface of the membrane, and wherein the mesh includes a plurality of openings formed through the mesh's thickness, and wherein the transducer is coupled to a power source and is operable to oscillate the vibrating member and the membrane and generate an ejected stream of droplets through the mesh; an ejection channel within the container assembly configured to direct the ejected stream of droplets from the mesh to an outlet; and a central axis of the droplet delivery device passing through the ejection channel and the membrane, and wherein the vibrating member includes a tip coupling to the membrane at a position offset from the central axis. 7. A droplet delivery device comprising: a container assembly with a mouthpiece port; a reservoir disposed within or in fluid communication with the container assembly and configured to supply a volume of fluid; an ejector bracket in fluid communication with the reservoir, the ejector bracket including a mesh with a membrane operably coupled to a vibrating member that is coupled to an electronic transducer with the membrane between the vibrating member and the mesh, wherein an exterior surface of the membrane, opposite an underlying surface of the membrane contacting the vibrating member, includes a hydrophilic coating, and wherein the mesh includes a plurality of openings formed through the mesh's thickness, and wherein the transducer is coupled to a power source and is operable to oscillate the vibrating member and the membrane and generate an ejected stream of droplets through the mesh; and an ejection channel within the container assembly configured to direct the ejected stream of droplets from the mesh to an outlet.
by passing the aerosol trough sieves or filters · CPC title
using ultrasonics (spraying or atomising liquids using ultrasonic vibrations in general B05B17/06) · CPC title
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with air flow regulating means · CPC title
using ultrasonics (spraying or atomising liquids using ultrasonic vibrations in general B05B17/06) · CPC title
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