Topical composition

Patent metadata

Field	Value
Publication number	US-11793741-B2
Application number	US-201816766830-A
Country	US
Kind code	B2
Filing date	Dec 17, 2018
Priority date	Dec 18, 2017
Publication date	Oct 24, 2023
Grant date	Oct 24, 2023

Abstract

The present invention relates to a topical composition comprising from 0.001 to 10% by weight a compound of formula (I), i.e. N-cyclopropyl nicotinamide, that provides improved antimicrobial effect through generation of antimicrobial peptides when applied to an external surface of the human body. A combination of compound of formula I and at least one ingredient selected from niacinamide, picolinamide and iso-nicotinamide triggers generation of AMPs in a synergistic way.

First claim

The invention claimed is:

1. A topical composition comprising from 0.001 to 10% by weight a compound of formula I,

further comprising from 0.001 to 10% by weight of at least one ingredient selected from niacinamide, picolinamide and iso-nicotinamide.

2. The topical composition of claim 1 , wherein the ingredient is niacinamide.

3. The topical composition of claim 1 , further comprising a cosmetically accepted base.

4. The topical composition of claim 1 , wherein the composition is in the form of a wash-off composition.

5. The topical composition of claim 1 , wherein the composition is in the form of a leave-on composition.

6. The topical composition of claim 1 , wherein said leave-on composition includes lotion, cream, deodorants, hand sanitizer and body spray.

7. The topical composition of claim 1 , wherein the topical composition is configured for obtaining an antimicrobial benefit.

8. The topical composition of claim 7 , wherein the antimicrobial benefit includes killing or reducing disease causing microbes.

9. The topical composition of claim 1 , wherein the topical composition is configured to induce secretion of antimicrobial peptides when applied on an external surface of a human body.

10. The topical composition of claim 1 , wherein the topical composition provides 24-hour protection against germs.

11. A method of disinfecting a surface comprising the step of applying on to the surface a composition as claimed in claim 1 .

12. The method of claim 11 , wherein the composition is in the form of a wash- off composition and wherein the method comprises an additional step of at least partially removing the composition.

13. The method of claim 12 , wherein the step of at least partially removing the composition is carried out in less than 5 minutes after the step of applying the composition on the substrate.

14. A method for obtaining an antimicrobial benefit by using the topical composition of claim 1 .

15. A method for inducing secretion of anti-microbial peptides (AMPs) when applied on an external surface of the human body by using the topical composition of claim 1 .

16. The method of claim 14 , comprising 0.001 to 10% of compound of formula 1,

for the antimicrobial benefit.

Assignees

• Conopco Inc

Inventors

• Agarwal Khushbu
• Kunjupillai Balu
• Majumdar Amitabha

Classifications

• A61K8/4926 Primary

  having six membered rings · CPC title

• A61K8/675

  Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde (tocopheryl nicotinate A61K8/678) · CPC title

• A61Q15/00

  Anti-perspirants or body deodorants (deodorisation of air A61L9/00) · CPC title

• A61Q17/005

  Antimicrobial preparations · CPC title