Device for supporting an image capturing device on a bioreactor, bioreactor with device for supporting an image capturing device, and method for propagation or cultivation of biological material

Patent metadata

Field	Value
Publication number	US-11788669-B2
Application number	US-201916379454-A
Country	US
Kind code	B2
Filing date	Apr 9, 2019
Priority date	Apr 9, 2018
Publication date	Oct 17, 2023
Grant date	Oct 17, 2023

Abstract

A supporting device for an image capturing device on a bioreactor, a bioreactor, and a method of use are provided. The supporting device for an image capturing device includes a window and a holder. The window has a transparent element that is transparent to electromagnetic radiation. The holder is configured to hold the image capturing device. The supporting device is held at least partially in a through-opening of a feedthrough of a container for holding fluid media containing biological material. The window seals the through-opening.

First claim

What is claimed is:

1. A device for supporting an image capturing device in a feedthrough of a bioreactor, comprising:
a window including a transparent element, the transparent element is transparent to electromagnetic radiation; and
a holder for the image capturing device, wherein the holder comprises a holder body made of a high temperature resistant plastic selected from the group consisting of a thermoplastic material, polyaryletherketone, and polyetheretherketone,
wherein the holder body has a columnar receiving area or through-opening of circular cross-sectional shape, wherein the transparent element has a circular outer lateral contour and an outer diameter that is larger than the inner diameter of the circular receiving area or through-opening of the holder body by about 10%, wherein the transparent element is inserted into the receiving area or through-opening of the holder body when the holder body is heated to a temperature of about 200° C., and wherein when being cooled down, results in a compressive stress on the transparent element,
wherein the holder body has a portion that is sized and configured to pass into an interior of the bioreactor from an exterior of the bioreactor through the feedthrough, and
wherein the transparent element of the window has a shape selected from a group consisting of sheet, plano-convex, plano-concave, biconvex, biconcave, convexo-concave, and concavo-convex.

2. The device of claim 1 , wherein the holder has a cylindrically symmetrical shape and has a receiving area, the window hermetically sealing the receiving area on a side associated with the interior of the bioreactor.

3. The device of claim 1 , wherein the transparent element exhibits a transmittance of greater than 80% in a spectral range of wavelengths between 250 and 2000 nm.

4. The device of claim 1 , wherein the transparent element of the window comprises a material selected from a group consisting of glass, quartz glass, and borosilicate glass.

5. The device of claim 1 , wherein the transparent element forms part of a microscopic device.

6. The device of claim 1 , wherein the holder has a radially extending lateral shoulder, the lateral shoulder being positioned a first axial distance from the transparent element so that the first axial distance defines a second axial distance between the transparent element and the inner surface of the bioreactor.

7. The device of claim 6 , further comprising an illumination device disposed on the holder at a side of the holder configured to be in the inner surface of the bioreactor.

8. The device of claim 1 , further comprising an illumination device, the illumination device having a housing and a second window including a second transparent element.

9. The device of claim 8 , wherein the second transparent element is secured to the housing by a compression glass seal or welding.

10. The device of claim 8 , wherein the transparent element and the second transparent element have a predefined spacing from each other.

11. The device of claim 8 , further comprising a first electrical connector on the holder and a second electrical connector the housing, wherein the first and second electrical connectors are each hermetically sealed and complementary interengagable.

12. The device of claim 8 , further comprising a first inductive coupler on the holder and a second inductive coupler on the housing, wherein the first and second inductive couplers are each hermetically sealed and adapted to be coupled inductively.

13. The device of claim 8 , wherein the illumination device comprises an LED or an array of LEDs arranged in the housing.

14. The device of claim 13 , further comprising an associated electronic device configured to control the LED or array of LED's stroboscopically.

15. The device of claim 8 , wherein the illumination device is autoclavable.

16. The device of claim 1 , wherein the window is sized and configured to pass into the interior of the bioreactor from the exterior of the bioreactor through the feedthrough.

17. A device for supporting an image capturing device in a feedthrough of a bioreactor, comprising:
a window including a transparent element, the transparent element is transparent to electromagnetic radiation; and
a holder for the image capturing device, wherein the holder comprises a holder body made of a high temperature resistant plastic selected from the group consisting of a thermoplastic material, polyaryletherketone and polyetheretherketone,
wherein the holder body has a columnar receiving area or through-opening of circular cross-sectional shape, wherein the transparent element has a circular outer lateral contour and an outer diameter that is larger than the inner diameter of the circular receiving area or through-opening of the holder body by about 10%, wherein the transparent element is inserted into the receiving area or through-opening of the holder body when the holder body is heated to a temperature of about 200° C., and wherein when being cooled down results in a compressive stress on the transparent element,
wherein the holder body has a portion that is sized and configured to pass into an interior of the bioreactor from an exterior of the bioreactor through the feedthrough, and
wherein the transparent element of the window has a shape selected from a group consisting of plano-convex, plano-concave, biconvex, biconcave, convexo-concave, and concavo-convex.

Assignees

• Schott Ag

Inventors

• Ott Christian
• Hettler Robert

Classifications

• F16M11/00 Primary

  Stands or trestles as supports for apparatus or articles placed thereon {; Stands for scientific apparatus such as gravitational force meters} (without heads F16M13/00; easels or stands for blackboards or the like A47B97/04; show-stands A47F7/00; for workmen E04G1/32; {sockets or holders for poles or posts E04H12/22;} supporting or suspending for lighting devices F21V21/00) · CPC title

• C12M23/22

  Transparent or translucent parts (glassware for laboratory use B01L3/00) · CPC title

• C12M23/48

  Holding appliances; Racks; Supports (holding devices for laboratory apparatus B01L9/00) · CPC title

• C12M31/10

  by light emitting elements located inside the reactor, e.g. LED or OLED · CPC title

• C12M37/04

  Seals · CPC title