Method and device for determining a concentration of at least one analyte

Patent metadata

Field	Value
Publication number	US-11782009-B2
Application number	US-202117443260-A
Country	US
Kind code	B2
Filing date	Jul 23, 2021
Priority date	Dec 21, 2016
Publication date	Oct 10, 2023
Grant date	Oct 10, 2023

Abstract

A method for determining a concentration of at least one analyte in bodily fluid, comprising: a signal generation step, wherein an excitation voltage signal is generated by a signal generator, wherein the excitation voltage signal comprises a poly frequent alternating current (AC) voltage and a direct current (DC) voltage profile, wherein the poly frequent AC voltage comprises at least two frequencies; a signal application step, wherein the excitation voltage signal is applied to at least two measurement electrodes; a measurement step, wherein a response is measured by using the measurement electrodes; an evaluation step, wherein an AC current response for each frequency and a DC current response are evaluated from the response; a determination step, wherein the concentration of the analyte is determined from the DC current response and from one or both of the phase and impedance information by using at least one predetermined relationship.

First claim

What is claimed is:

1. An analytical device for determining a concentration of at least one analyte in bodily fluid, the analytical device comprising:
at least one signal generator device adapted to generate at least one excitation voltage signal, wherein the excitation voltage signal comprises at least one poly frequent alternating current (AC) voltage and at least one direct current (DC) voltage profile, wherein the poly frequent AC voltage comprises at least two frequencies;
at least one measurement unit, wherein the measurement unit is adapted to receive a response,
at least one evaluation device adapted to evaluate an AC current response for each frequency and a DC current response from the response, wherein the evaluation device is adapted to evaluate for each frequency at least one phase information and at least one impedance information is evaluated from the AC current response,
wherein the evaluation device is adapted to determine a concentration of the analyte from the DC current response and from one or both of the phase information and impedance information by using at least one predetermined relationship,
wherein the AC voltage and DC profile are superimposed to form the excitation voltage signal, and
wherein the evaluation device is adapted to determine a predetermined relationship between the concentration of the analyte and the DC current response, the phase information and impedance information, or
wherein the evaluation device is adapted to deposit and/or store a predetermined relationship between the concentration of the analyte and the DC current response, the phase information and impedance information in a storage of the evaluation device.

2. The analytical device according to claim 1 , wherein the predetermined relationship is
bG=Σ i=1 n α i DC i e Σ m=1 f bm i Ym i +cm i Pm i ,

wherein bG is the determined analyte concentration, i denotes the number of measurement time points, wherein i, n, f and m are natural integer numbers, m denotes the number of frequencies, a i , b i , c i are weighting coefficients, Ym j are admittance values from AC response at different frequencies at time points, Pm j are phase angle values from AC response at different frequencies at time points and DC i are DC response values at selected DC response time points.

3. The analytical device according to claim 1 , wherein the predetermined relationship is

b
⁢
G

=

∑

i
=
1

n

∑

m
=
1

f

(

a

m
⁢
i

⁢

DC

i

Y

(
imag
)

⁢
m
⁢
i

+

b

m
⁢
i

⁢

DC

i

Y

(
real
)

⁢
m
⁢
i

)

,

wherein bG is the determined analyte concentration, i denotes the number of measurement time points, wherein i, n, f and m are natural integer numbers, m denotes the number of frequencies, ai are weighting coefficients, Y (imag)mi and Y (real)mi are real and imaginary parts of admittance values from AC response at different frequencies at time points and DC i are DC response values at selected DC response time points.

4. The analytical device according to claim 3 , wherein the predetermined relationship is,

bG
=

∑

i
,

j
=
1

i
≠
j

n

(

a
i

⁢

DC

i

Y
i

+

b
i

(

DC

i

Assignees

• Roche Diagnostics Operations Inc

Inventors

• Marquant Michael
• Evgin Samuel
• Klein Melanie

Classifications

• G01N27/3274 Primary

  Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration (coding of calibration information G01N33/48771) · CPC title

• G06F17/10

  Complex mathematical operations {(function generation by table look-up G06F1/03; evaluation of elementary functions by calculation G06F7/544)} · CPC title

• G01N33/492

  Determining multiple analytes · CPC title