Substituted diaminocarboxamide and diaminocarbonitrile pyrimidines, compositions thereof, and methods of treatment therewith
US-2017267647-A1 · Sep 21, 2017 · US
Methods of synthesis of (1R,2R,5R)-5-amino-2-methyl-cyclohexanol hydrochloride and intermediates useful therein
US11780801B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11780801-B2 |
| Application number | US-202117518552-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 3, 2021 |
| Priority date | Jul 24, 2015 |
| Publication date | Oct 10, 2023 |
| Grant date | Oct 10, 2023 |
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- Title
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Abstract
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Provided herein are methods and intermediates for making (1R, 2R, 5R)-5-amino-2-methylcyclohexanol hydrochloride, which are useful for the preparation of compounds useful for the treatment of a disease, disorder, or condition associated with the JNK pathway.
First claim
Opening claim text (preview).
What is claimed is: 1. A method for preparing a compound of formula (9): the method comprising contacting a compound of formula (8): with a mixture of a reducing agent, a chiral auxiliary and a Lewis acid in a solvent, followed by treatment with an oxidant in the presence of a base. 2. The method of claim 1 , wherein the reducing agent is NaBH 4 . 3. The method of claim 1 , wherein the chiral auxiliary is α-pinene. 4. The method of claim 1 , wherein the Lewis acid is BF 3 ·Et 2 O. 5. The method of claim 1 , wherein the solvent is THF or EtOH. 6. The method of claim 1 , wherein the solvent is THF. 7. The method of claim 1 , wherein the solvent is EtOH. 8. The method of claim 1 , wherein the oxidant is H 2 O 2 or oxone. 9. The method of claim 1 , wherein the oxidant is H 2 O 2 . 10. The method of claim 1 , wherein the base is NaOH. 11. The method of claim 1 , wherein the reducing agent is NaBH 4 , the chiral auxiliary is α-pinene, the Lewis acid is BF 3 ·Et 2 O, and the solvent is THF. 12. The method of claim 11 , wherein the oxidant is H 2 O 2 and the base is NaOH.
Assignees
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Classifications
- C07C213/02Primary
by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups · CPC title
from carboxylic acid esters or lactones · CPC title
by addition to unsaturated carbon-to-carbon bonds · CPC title
from or via amides · CPC title
Separation of optical isomers · CPC title
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- What does patent US11780801B2 cover?
- Provided herein are methods and intermediates for making (1R, 2R, 5R)-5-amino-2-methylcyclohexanol hydrochloride, which are useful for the preparation of compounds useful for the treatment of a disease, disorder, or condition associated with the JNK pathway.
- Who is the assignee on this patent?
- Celgene Corp
- What technology area does this patent fall under?
- Primary CPC classification C07C213/02. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Oct 10 2023 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 12 related publications on this page (citations in our corpus or others sharing the same primary CPC).