Magnetic-optical composite nanostructure

Patent metadata

Field	Value
Publication number	US-11779896-B2
Application number	US-202016987816-A
Country	US
Kind code	B2
Filing date	Aug 7, 2020
Priority date	Aug 13, 2019
Publication date	Oct 10, 2023
Grant date	Oct 10, 2023

Abstract

The present invention relates to a magnetic-optical composite nanostructure, which has a heterogeneous nature due to consisting of a first core-shell nanoparticle and second core-shell nanoparticles and thus realizes magnetic and optical functions at the same time.

First claim

What is claimed is:

1. A method of manufacturing a magnetic-optical composite nanostructure, comprising:
preparing a first core-shell nanoparticle by forming a ceramic shell on a magnetic nanoparticle;
preparing a gold nanoparticle-attached core-shell nanoparticle by attaching gold nanoparticles to the first core-shell nanoparticle;
primarily growing the gold nanoparticles of the gold nanoparticle-attached core-shell nanoparticle;
preparing a Raman molecule-functionalized core-shell nanoparticle by functionalizing the primarily grown gold nanoparticles with a Raman molecule; and
preparing second core-shell nanoparticles by forming a gold, silver, or gold-silver alloy shell on each of the Raman molecule-functionalized gold nanoparticles of the Raman molecule-functionalized core-shell nanoparticle,
wherein in the forming of the gold, silver, or gold-silver alloy shell, the concentration of gold ions in a gold ion precursor solution and the concentration of silver ions in a silver ion precursor solution are in the range of 0.01 mM to 1 M, and the weight ratio of the gold ion precursor solution and the silver ion precursor solution is 1:0 to 0:1.

2. The method of claim 1 , wherein the magnetic nanoparticle is a metal oxide nanoparticle, and the metal oxide is one or more selected from the group consisting of FeO, Fe 2 O 3 , Fe 3 O 4 , CoFe 2 O 4 , NiFe 2 O 4 , MnFe 2 O 4 , TiO 2 , ZrO 2 , CeO 2 , Al 2 O 3 , and MgO.

3. The method of claim 1 , wherein the magnetic nanoparticle has an average particle diameter of 10 to 500 nm.

4. The method of claim 1 , wherein the ceramic includes one or more selected from the group consisting of silica, titania, zirconia, alumina, and zeolite.

5. The method of claim 1 , wherein the preparing the gold nanoparticle-attached core-shell nanoparticle includes:
introducing a functional group onto a surface of the shell of the first core-shell nanoparticles; and
allowing a gold nanoparticle seed to be bonded to the functional group.

6. The method of claim 5 , wherein the functional group includes one or more selected from the group consisting of an amine group (—NH), a thiol group (—SH), a carboxyl group (—COOH), a hydroxyl group (—OH), and dopamine.

7. The method of claim 1 , wherein, in the primarily growing the gold nanoparticles, the grown gold nanoparticles have an average particle diameter of 5 to 50 nm.

8. The method of claim 1 , wherein in the preparing the Raman molecule-functionalized core-shell nanoparticle, the Raman molecule includes one or more selected from the group consisting of 1,4-benzenedithiol (BDT), fluorescein (FAM), Dabcyl, tetramethyl rhodamine isothiol (TRIT), 7-nitrobenz-2-oxa-1,3-diazol (NBD), Texas Red dye, phthalic acid, terephthalic acid, isophthalic acid, Cresyl Fast Violet, Cresyl Blue Violet, Brilliant Cresyl Blue, para-aminobenzoic acid, erythrosine, biotin, digoxigenin, 5-carboxy-4′,5′-dichloro-2′,7′-dimethoxy, 5-carboxy-2′,4′,5′,7′-tetrachlorofluorescein, 5-carboxyfluorescein, 5-carboxyrhodamine, 6-carboxyrhodamine, 6-carboxytetramethyl aminophthalocyanine, azomethine, xanthine, succinylfluorescein, aminoacridine, a quantum dot, a carbon nanotube, a carbon allotrope, a cyanide, a thiol, chlorine, bromine, methyl, phosphorus, sulfur, a cyanine dye (Cy3, Cy3.5, or Cy5), and rhodamine.

9. The method of claim 1 , wherein, when only the gold ion precursor solution is used or a mixed solution of the gold ion precursor solution and the silver ion precursor solution in which the amount of the gold ions is 50 mol % or more relative to the sum of the amounts of the gold ions and the silver ions is used, the shell exhibits an epitaxial growth pattern.

10. The method of claim 9 , wherein the size of the epitaxially grown second core-shell nanoparticle is in the range of 5 nm to 100 nm.

11. The method of claim 1 , wherein, when only the silver ion precursor solution is used or a mixed solution of the gold ion precursor solution and the silver ion precursor solution in which the amount of the silver ions is more than 50 mol % relative to the sum of the amounts of the gold ions and the silver ions is used, the shell grows as a crystalline island.

12. The method of claim 11 , wherein the size of the second core-shell nanoparticle exhibiting the growth of a silver island is in the range of 5 nm to 500 nm.

Assignees

• Univ Korea Res & Bus Found

Inventors

• Kim Young Keun
• Kim Yu Jin
• Park Bum Chul
• Kim Myeong Soo

Classifications

• B01J13/02 Primary

  Making microcapsules or microballoons {(for medical preparations A61K9/50)} · CPC title

• B03C1/30

  Combinations with other devices, not otherwise provided for · CPC title

• G01N33/54326

  Magnetic particles · CPC title

• G01N33/54346 Primary

  Nanoparticles · CPC title

• G01N33/54353

  with ligand attached to the carrier via a chemical coupling agent (coatings G01N33/54393) · CPC title