Stimulator systems and methods for selectively recruiting fascicles in hypoglossal nerve trunk

Patent metadata

Field	Value
Publication number	US-11779759-B2
Application number	US-202117190612-A
Country	US
Kind code	B2
Filing date	Mar 3, 2021
Priority date	Aug 30, 2017
Publication date	Oct 10, 2023
Grant date	Oct 10, 2023

Abstract

An electrode lead comprises a lead body, connector contacts affixed to the proximal end of the lead body, and a cuff body affixed to the distal end of the lead body. The cuff body is pre-shaped to transition from an unfurled state to a furled state, wherein the cuff body, when in the furled state has an inner surface for contacting a nerve and an overlapping inner cuff region and an outer cuff region. The electrode lead further comprise electrode contacts circumferentially disposed along the cuff body when in the furled state, such that at least one of the electrode contacts is located on the inner surface of the cuff body, and at least another of the electrode contacts is located between the overlapping inner and outer cuff regions. The electrode lead further comprises electrical conductors extending through the lead body respectively between the connector contacts and the electrode contacts.

First claim

What is claimed is:

1. A method of stimulating a nerve of a patient to treat an ailment, the nerve having a plurality of peripherally located fascicles and at least one centrally located fascicle, the method comprising:
circumferentially disposing a plurality of axially aligned electrode contacts around the nerve, such that each of all available pairs of immediately adjacent ones of the plurality of electrode contacts has a center-to-center circumferential spacing that is equal to or less than twice the circumferential width of an electrode contact of the respective pair of immediately adjacent electrode contacts; and
delivering an electrical pulse train between a pair of immediately adjacent ones of the plurality of electrode contacts, thereby creating a confined bipolar electrical field that recruits one or more of the peripherally located fascicles to treat the ailment, while not recruiting the at least one centrally located fascicle.

2. The method of claim 1 , wherein the nerve has a diameter in the range of 2.5 mm to 4.0 mm.

3. The method of claim 1 , wherein the plurality of electrode contacts comprises at least three electrode contacts.

4. The method of claim 1 , wherein the plurality of electrode contracts comprises at least six electrode contacts.

5. The method of claim 1 , wherein the peripherally located fascicles innervate tongue protrusor muscles of the patient.

6. The method of claim 5 , wherein the nerve is a hypoglossal nerve (HGN) trunk.

7. The method of claim 6 , wherein the pair of immediately adjacent ones of plurality of electrode contacts is located on the HGN trunk proximal to a medial branch of the HGN trunk.

8. The method of claim 6 , wherein the ailment is obstructive sleep apnea (OSA).

9. The method of claim 1 , further comprising delivering another electrical pulse train between another pair of immediately adjacent ones of the plurality of electrode contacts, thereby creating another confined bipolar electrical field that recruits a different one or more of the peripherally located fascicles to treat the ailment, while not recruiting the at least one centrally located fascicle.

10. The method of claim 1 , wherein none of the at least one centrally located fascicle is recruited by the electrical pulse train delivered to the pair of immediately adjacent electrode contacts.

11. The method of claim 1 , further comprising repeating the electrical pulse train delivery step for different pairs of immediately adjacent ones of the plurality of electrode contacts until all peripherally located fascicles of the nerve have been recruited.

Assignees

• The Alfred E Mann Foundation For Scient Research
• The Alfred E Mann Foundation For Scientic Res

Inventors

• NG Boon Khai
• Calderon Joseph L

Classifications

• A61N1/3601 Primary

  of respiratory organs · CPC title

• A61B5/4818

  Sleep apnoea · CPC title

• A61N1/0556 Primary

  Cuff electrodes · CPC title

• A61N1/36139

  with automatic adjustment · CPC title

• A61N1/37211

  Means for communicating with stimulators · CPC title