Oral compositions and methods of use

Patent metadata

Field	Value
Publication number	US-11779446-B2
Application number	US-201816196872-A
Country	US
Kind code	B2
Filing date	Nov 20, 2018
Priority date	Nov 21, 2017
Publication date	Oct 10, 2023
Grant date	Oct 10, 2023

Abstract

Compositions that include: from 5 wt-% to 30 wt-% of one or more plant based oils based on the total weight of the composition; from 70 wt-% to 95 wt-% of an aqueous phase based on the total weight of the composition; from 0.1 wt-% to 5 wt-% of one or more surfactants based on the total weight of the composition; and from 0.05 wt-% to 3 wt-% of a viscosity modifier, wherein the composition has a pH from 4.5 to 9.5, the composition is an oil in water (o/w) emulsion, and the composition is edible. Methods of utilizing disclosed compositions are also included.

First claim

What is claimed is:

1. A method of reducing one or more symptoms associated with one or more of xerostomia and dry mouth, the method comprising:
contacting an oral tissue with an edible oil-in-water composition,
the edible oil-in-water composition comprising:
an oil phase comprising:
one or more plant-based oils present in a total amount from 5 wt-% to 30 wt-% based on the total weight of the edible oil-in-water composition;

an aqueous phase comprising:
water,

wherein the aqueous phase is present in an amount from 70 wt-% to 95 wt-% based on the total weight of the edible oil-in-water composition;
one or more polyglycerol ester surfactant present in a total amount from 0.1 wt-% to 2 wt-% based on the total weight of the edible oil-in-water composition,
viscosity modifiers present in a total amount from 0.05 wt % to 3 wt-% based on the total weight of the composition,
wherein at least one viscosity modifier is ethyl cellulose, and
wherein at least one viscosity modifier is selected from hydroxypropyl guar and xanthan gum,

wherein the edible oil-in-water composition is characterized by a pH from 4.5 to 9.5.

2. The method of claim 1 , the edible oil-in-water composition comprising xanthan gum present in an amount from 0.5 wt % to 0.7 wt % based on the weight of the aqueous phase.

3. The method of claim 1 , wherein the viscosity modifiers are present in an amount not less than 0.2 weight percent based on the total weight of the edible oil-in-water composition.

4. The method of claim 1 , wherein the edible oil-in-water composition further comprises fish oil.

5. The method according to claim 1 , wherein the edible oil-in-water composition further comprises sweeteners, humectants, mineral salts, remineralizing agents, caries preventing agents, buffering components, flavorants, preservative agents, or a combination thereof.

6. The method of claim 1 , wherein the edible oil-in-water composition comprises at least 2 wt % ethyl cellulose based on the weight of the oil phase, and 0.5 wt % to 0.7 wt % of hydroxypropyl guar or xanthan gum or based on the weight of the aqueous phase.

7. The method according to claim 1 , the edible oil-in-water composition further comprising a viscosity modifier selected from fumed silica, wherein the fumed silica is present in an amount not less than 0.5 wt-% based on the total weight of the edible oil-in-water composition.

8. The method according to claim 1 , the polyglycerol ester is selected from polyglyceryl-10 stearate, polyglyceryl-10 dipalmitate, polyglyceryl-6-distearate, polyglyceryl-10 oleate, polyglyceryl-10 caprylate/caprate, and a combination thereof.

9. The method according to claim 1 , wherein the one or more edible plant based oils are selected from: sunflower oil, safflower oil, olive oil, coconut oil, palm oil, peanut oil, soybean oil, linseed oil, rapeseed oil, flaxseed oil, hempseed oil, cocoa butter, walnut oil, corn oil, grape seed oil, sesame oil, groundnut oil, wheat germ oil, cottonseed oil, watermelon seed oil, lemon oil, orange oil, thistle oil, tomato seed oil, almond oil, perilla oil, canola oil, pistachio oil, hazelnut oil, and avocado oil.

10. The method according to claim 1 , wherein the one or more edible plant-based oils are present in an amount from 10 wt-% to 25 wt-% based on the total weight of the edible oil-in-water composition.

11. The method according to claim 10 , wherein the one or more edible plant-based oils are present in an amount from 15 wt-% to 22 wt-% based on the total weight of the edible oil-in-water composition.

12. The method of claim 5 , wherein the edible oil-in-water composition further comprises a remineralizing agent selected from calcium chloride.

13. The method according to claim 1 , wherein the edible oil-in-water composition further comprises aloe vera, folic acid, hyaluronic acid, ceramides, betaines or oxygenated glycerol triesters, vitamin E, vitamin B12, EDTA, cetyl pyridinium chloride, chlorhexidine, other antiseptics, or a combination thereof.

14. The method according to claim 5 , wherein the preservative agents are a combination of at least CPC, vitamin E, paraben.

15. The method according to claim 5 , wherein the edible oil-in-water composition further comprises a sweetener present in an amount from 1 wt-% to 35 wt-% based on the total weight of the edible oil-in-water composition.

16. The method according to claim 5 , wherein the edible oil-in-water composition further comprises a humectant present in an amount from 2.5 wt-% to 40 wt-% based on the total weight of the edible oil-in-water composition.

17. The method according to claim 13 , wherein the edible oil-in-water composition excludes quaternary antimicrobial compounds.

18. The method according to claim 1 , wherein the edible oil-in-water composition is characterized by a viscosity effective for use as a sprayable composition.

19. The method according to claim 1 , wherein the edible oil-in-water composition remains physically stable and does not separate into water and oil phases when subjected to normal room temperature conditions, when subjected to temperatures approaching or surpassing the freezing point of the edible oil-in-water composition and subsequently thawed, or combinations thereof.

20. The method according to claim 1 , wherein the edible oil-in-water composition reduces hydration loss in an area contacted by the edible oil-in-water composition.

21. The method according to claim 1 , wherein the edible oil-in-water composition increases lubricity or lubriciousness of an area contacted by the edible oil-in-water composition.

Assignees

• 3M Innovative Properties Company

Inventors

• Wlaschin Katie F
• Engler Amanda C
• Cohen Hannah C
• Wang Yizhong
• Gong Tao
• Ton Tiffany T
• Oxman Joel D
• Yang Jie
• Rusin Richard P

Classifications

• A61K36/5777

  Theobroma, e.g. cocao or cocoa · CPC title

• A61K36/3482

  Cannabis · CPC title

• A61K36/577

  Malvaceae (Mallow family) · CPC title

• A61K36/185

  Magnoliopsida (dicotyledons) · CPC title

• A61C19/063 Primary

  Medicament applicators for teeth or gums, e.g. treatment with fluorides · CPC title