Pressure sensing ventricular assist devices and methods of use

Patent metadata

Field	Value
Publication number	US-11779234-B2
Application number	US-202017028687-A
Country	US
Kind code	B2
Filing date	Sep 22, 2020
Priority date	Mar 29, 2017
Publication date	Oct 10, 2023
Grant date	Oct 10, 2023

Abstract

The invention generally relates to heart pump systems. In some embodiments, a pressure sensor is provided with a heart pump, either at the inflow or the outflow of the blood pump. The heart pump may further include a flow estimator based on a rotor drive current signal delivered to the rotor. Based on the rotor drive current signal, a differential pressure across the pump may be calculated. The differential pressure in combination with the pressure measurements from the pressure sensor may be used to calculate pressure on the opposite side of the pump from the pressure sensor. In some embodiments, the pressure sensor is located at the outflow of the pump and the pump is coupled with the left ventricle. The differential pressure and pressure measurement may be used to calculate a left ventricular pressure waveform of the patient. With such a measurement, other physiological parameters may be derived.

First claim

What is claimed is:

1. A blood pump system, the system comprising:
a blood pump comprising an inflow and an outflow,
an upstream pressure sensor coupled with the outflow of the blood pump at an upstream location;
a downstream pressure sensor coupled with the outflow of the blood pump at a downstream location; and
a controller operably coupled with the blood pump, the upstream pressure sensor, and the downstream pressure sensor, the controller configured to:
calibrate measurements from the upstream pressure sensor and the downstream pressure sensor to account for sensor drift;
determine a differential pressure across the blood pump; and
calculate, based on the differential pressure: 1) a pressure at the inflow of the blood pump, or 2) a pressure at the outflow of the blood pump.

2. The blood pump system of claim 1 , wherein the controller is further configured to:
generate a desired data waveform based on the calculated pressure; and
output the generated data waveform.

3. The blood pump system of claim 2 , wherein the controller is configured to adjust a pumping of the blood pump in response to the generated data waveform.

4. The blood pump system of claim 2 , wherein the controller is configured to adjust a pumping mode of the blood pump in response to the generated data waveform.

5. The blood pump system of claim 2 , wherein the controller adjusts a pump rotor speed in response to the generated data waveform.

6. The blood pump system of claim 2 , wherein the generated data waveform comprises a left ventricular pressure waveform and wherein the left ventricular pressure waveform is calculated by subtracting the differential pressure from the calculated pressure.

7. The blood pump system of claim 1 , wherein the upstream pressure sensor is integrated into a housing of the blood pump at the outflow of the blood pump.

8. The blood pump system of claim 1 , wherein the upstream pressure sensor is positioned within an outflow graft coupled to the blood pump.

9. The blood pump system of claim 1 , wherein the controller determines the differential pressure across the blood pump by accessing a lookup table associating rotor drive current signal values with differential pressure values.

10. The blood pump system of claim 1 , further comprising a pulmonary pressure sensor configured to be implanted within a pulmonary artery of a patient, wherein the controller is further configured to:
receive pulmonary pressure measurements from the pulmonary pressure sensor; and
estimate a left atrial pressure waveform or a left ventricular pressure waveform based on the pulmonary pressure measurements.

11. A blood pump system, the system comprising:
a blood pump comprising an inflow and an outflow,
an upstream pressure sensor coupled with the outflow of the blood pump at an upstream location;
a downstream pressure sensor coupled with the outflow of the blood pump at a downstream location; and
a controller operably coupled with the blood pump, the upstream pressure sensor, and the downstream pressure sensor, the controller configured to:
determine a differential pressure across the blood pump based on a rotor drive current signal configured to drive the blood pump; and
calculate, based on the differential pressure: 1) a pressure at the inflow of the blood pump, or 2) a pressure at the outflow of the blood pump.

12. The blood pump system of claim 11 , wherein the controller is configured to calibrate measurements from the upstream pressure sensor and the downstream pressure sensor to account for sensor drift.

13. A method for hemodynamic monitoring of a patient with a heart pump, the method comprising:
determining a differential pressure across the heart pump having an inflow and an outflow;
receiving an upstream pressure measurement from an upstream pressure sensor coupled with the outflow of the heart pump at an upstream location;
receiving a downstream pressure measurement from a downstream pressure sensor coupled with the outflow of the heart pump at a downstream location;
calibrating measurements from the upstream pressure sensor and the downstream pressure sensor to account for sensor drift; and
generating a desired data waveform based on the differential pressure and at least one of the upstream pressure measurement or the downstream pressure measurement.

14. The method of claim 13 , comprising outputting the desired data waveform to a clinician.

15. The method of claim 13 , further comprising adjusting a pump operation based on the desired data waveform.

16. The method of claim 13 , wherein the heart pump is configured to be coupled with a right ventricle of the patient, and wherein the desired data waveform comprises a right ventricular pressure waveform.

17. The method of claim 13 , wherein the heart pump is configured to be coupled with a left atrium of the patient, and wherein the desired data waveform comprises a left atrial pressure waveform.

18. The method of claim 13 , wherein the heart pump is configured to be coupled with a left ventricle of the patient, and wherein the desired data waveform comprises a left ventricular pressure waveform.

19. A method for hemodynamic monitoring of a patient with a heart pump, the method comprising:
determining a differential pressure across the heart pump having an inflow and an outflow, wherein the differential pressure is determined based on a rotor drive current signal configured to drive the heart pump;
receiving an upstream pressure measurement from an upstream pressure sensor coupled with the outflow of the heart pump at an upstream location;
receiving a downstream pressure measurement from a downstream pressure sensor coupled with the outflow of the heart pump at a downstream location; and
generating a desired data waveform based on the differential pressure and at least one of the upstream pressure measurement or the downstream pressure measurement.

20. The method of claim 19 , further comprising calibrating measurements from the upstream pressure sensor and the downstream pressure sensor to account for sensor drift.

Assignees

• Tc1 Llc

Inventors

• Harjes Daniel I
• Frederick Kathryn B
• Lee Eric

Classifications

• A61B5/029 Primary

  Measuring blood output from the heart, e.g. minute volume · CPC title

• A61B5/0031

  Implanted circuitry · CPC title

• A61M60/148

  in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices · CPC title

• A61M60/178

  drawing blood from a ventricle and returning the blood to the arterial system via a cannula external to the ventricle, e.g. left or right ventricular assist devices · CPC title

• A61M60/221

  the blood flow through the rotating member having both radial and axial components, e.g. mixed flow pumps · CPC title