Anti-bril antibody

Patent metadata

Field	Value
Publication number	US-11773161-B2
Application number	US-202117226312-A
Country	US
Kind code	B2
Filing date	Apr 9, 2021
Priority date	Jul 13, 2017
Publication date	Oct 3, 2023
Grant date	Oct 3, 2023

Abstract

An object of the present invention is to provide a method of enabling efficient structural analysis of a target protein that has been impossible or difficult to analyze so far, by stabilizing the target protein. The present invention provides an anti-BRIL antibody which specifically binds to BRIL or a BRIL fusion protein and an antigen-binding fragment thereof, a nucleic acid encoding the anti-BRIL antibody and the antigen-binding fragment thereof, a vector containing the nucleic acid, an antibody producing cell containing the vector, a method of producing the antibody, and a method of using the antibody in a protein structural analysis.

First claim

The invention claimed is:

1. An anti-BRIL antibody or an antigen-binding fragment thereof, comprising:
VH CDRs 1 to 3 which comprise the amino acid sequences represented by SEQ ID NOs: 1 to 3, respectively, and
VL CDRs 1 to 3 which comprise the amino acid sequences represented by SEQ ID NOs: 4 to 6, respectively.

2. The anti-BRIL antibody or antigen-binding fragment thereof according to claim 1 ,
wherein the anti-BRIL antibody or antigen-binding fragment thereof is an antigen-binding fragment of the anti-BRIL antibody, and
wherein the antigen-binding fragment of the anti-BRIL antibody is selected from the group consisting of Fab, Fab′, F(ab′) 2 , scFv, diabody, dsFv, and a peptide containing a plurality of CDRs.

Assignees

• Kyowa Kirin Co Ltd

Inventors

• Miyagi Hikaru
• Suzuki Michihiko
• Saito Junichi
• Asada Hidetsugu
• Iwata So

Classifications

• C07K16/28 Primary

  against receptors, cell surface antigens or cell surface determinants · CPC title

• C07K14/705

  Receptors; Cell surface antigens; Cell surface determinants {(tumour specific antigens C07K14/4748)} · CPC title

• C07K14/723

  G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor · CPC title

• C07K2317/565

  Complementarity determining region [CDR] · CPC title

• C07K2319/30

  Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto · CPC title