MXene sorbent for removal of small molecules from dialysate

Patent metadata

Field	Value
Publication number	US-11772066-B2
Application number	US-202217670716-A
Country	US
Kind code	B2
Filing date	Feb 14, 2022
Priority date	Aug 1, 2017
Publication date	Oct 3, 2023
Grant date	Oct 3, 2023

Abstract

The present disclosure is directed to methods for scrubbing low levels of urea from aqueous solutions such as a dialysate from dialysis, and including blood and blood products, and devices capable of employing these methods.

First claim

What is claimed:

1. A device for removing urea from an initial aqueous solution of urea, the device comprising an exchangeable cartridge of a MXene composition through which the initial aqueous solution is directed to pass, the passage adapted to allow the initial aqueous urea solution to contact the MXene composition contained in the cartridge.

2. The device of claim 1 , wherein the device is adapted to allow the initial aqueous solution of urea to percolate through at least a portion of the MXene composition.

3. The device of claim 1 , wherein the device is adapted to effect removing urea from the initial aqueous solution of urea, the initial aqueous solution of urea contacting the MXene composition contained in the cartridge at ambient or near ambient temperatures and under conditions, so that the urea is reduced from an initial concentration in the initial aqueous solution to a final concentration in a final solution, wherein the initial concentration of urea in the initial aqueous solution is in a range of from 10 mmol/L to 1000 mmol/L, or is initially in a concentration range from 15 to 40 mb/dL mg/dL, and the final concentration is at least 10% less than the initial concentration, and wherein the initial aqueous solution is or comprises blood or a blood product and the ambient or near ambient temperatures and conditions used do not compromise the utility of the blood or blood product for later use by a human patient.

4. The device of claim 1 , wherein the MXene composition comprises a composition comprising at least one layer having first and second surfaces, each layer described by a formula M n+1 X n T, such that
each X is position within an octahedral array of M, wherein
M is at least on Group IIIB, IVB, VB, or VIB metal, wherein
each X is C, N, or a combination thereof,
n=1, 2, or 3; and wherein
T represents surface termination groups.

5. The device of claim 4 , wherein a surface termination group comprises alkoxide, carboxylate, halide, hydroxide, hydride, oxide, sub-oxide, nitride, sub-nitride, sulfide, thiol, or a combination thereof.

6. The device of claim 4 , wherein M is at least one group IVB, Group VB, or Group VIB metal.

7. The device of claim 4 , wherein M is Ti, Mo, Nb, V or Ta, or a combination thereof.

8. The device of claim 4 , wherein M n+1 X n is Ti 2 C, Mo 2 Ti 2 C, Mo 2 TiC 2 , Ti 3 C 2 , or a combination thereof.

9. The device of claim 1 , wherein the MXene composition comprises a composition comprising at least one layer having first and second surfaces, each layer comprising:
a. a substantially two-dimensional array of crystal cells,
b. each crystal cell having an empirical formula of M′ 2 M″ n X n+1 , such that each X is positioned within an octahedral array of M′ and M″, and where M″ 2 are present as individual two-dimensional array of atoms intercalated between a pair of two-dimensional arrays of M′ atoms,
c. wherein M′ and M″ are different Group IIIB, IVB, VB, or VIB metals,
d. wherein each X is C, N, or a combination thereof; and
e. n=1 or 2.

10. The device of claim 9 , wherein n is 1, M′ is Mo, and M″ is Nb, Ta, Ti, or V, or a combination thereof.

11. The device of claim 9 , wherein n is 2, M′ is Mo, Ti, V, or a combination thereof, and M″ is Cr, Nb, Ta, Ti, or V, or a combination thereof.

12. The device of claim 9 , wherein M′ 2 M″ n X n+1 comprises Mo 2 TiC 2 , Mo 2 VC 2 , Mo 2 TaC 2 , Mo 2 NbC 2 , Mo 2 Ti 2 C 3 , Cr 2 TiC 2 , Cr 2 VC 2 , Cr 2 TaC 2 , Cr 2 NbC 2 , Ti 2 NbC 2 , Ti 2 TaC 2 , V 2 TaC 2 , Mo 2 Ti 2 C 3 , Mo 2 V 2 C 3 , Mo 2 Nb 2 C 3 , Mo 2 Ta 2 C 3 , Cr 2 Ti 2 C 3 , Cr 2 V 2 C 3 , Cr 2 Nb 2 C 3 , Cr 2 Ta 2 C 3 , Nb 2 Ta 2 C 3 , Ti 2 Nb 2 C 3 , Ti 2 Ta 2 C 3 , V 2 Ta 2 C 3 , V 2 Nb 2 C 3 , or V 2 Ti 2 C 3 , or a nitride or carbonitride analog thereof.

13. The device of claim 9 , wherein the MXene composition comprises a plurality of stacked layers.

14. The device of claim 9 , wherein at least one of said surfaces of each layer has surface terminations comprising alkoxide, carboxylate, halide, hydroxide, hydride, oxide, sub-oxide, nitride, sub-nitride, sulfide, thiol, or a combination thereof.

15. The device of claim 1 , wherein the initial aqueous solution further comprises amino acids, polypeptides, or blood plasma proteins.

16. The device of claim 1 , wherein the aqueous solution further comprises one or more of erythrocytes, leukocytes, or thrombocytes.

17. The device of claim 1 , wherein the cartridge comprises channels coated with the MXene composition.

18. The device of claim 1 , wherein the MXene composition comprises Ti 3 C 2 T, wherein T is a surface termination group.

19. A method, comprising contacting an initial aqueous urea solution to a device according to claim 1 , the contacting being at ambient or near ambient temperatures and under such conditions that the urea is reduced from an initial concentration in the initial aqueous urea solution to a final concentration in a final solution, wherein the initial concentration of urea in the initial aqueous solution is in a range of from 10 mmol/L to 1000 mmol/L, or is initially in a concentration range from 15 to 40 mb/dL mg/dL, and the final concentration is at least 10% less than the initial concentration, and wherein the aqueous solution is or comprises blood or a blood product and the ambient or near ambient temperatures and conditions used do not compromise the utility of the blood or blood product for later use by a human patient.

20. The method of claim 19 , wherein the final concentration is at least 50% less than the initial concentration.

Assignees

• Univ Drexel
• Univ Of Brighton

Inventors

• Gogotsi Yury
• Mikhalovsky Sergey
• Sandeman Susan R
• Anasori Babak
• Meng Fayan

Classifications

• B01J20/0211 Primary

  Compounds of Ti, Zr, Hf · CPC title

• A61M1/1656

  Apparatus for preparing dialysates · CPC title

• B01D15/08

  Selective adsorption, e.g. chromatography · CPC title

• B01J20/0218 Primary

  Compounds of Cr, Mo, W · CPC title

• B01J20/0274

  characterised by the type of anion · CPC title