Combined degassing and circulation of liquid

Patent metadata

Field	Value
Publication number	US-11772012-B2
Application number	US-202016780366-A
Country	US
Kind code	B2
Filing date	Feb 3, 2020
Priority date	Feb 4, 2019
Publication date	Oct 3, 2023
Grant date	Oct 3, 2023

Abstract

A degasser for at least partially degassing a gas-containing liquid, in particular for a sample separation device, includes a circulation path along which the liquid can be circulated between a liquid accommodation volume and one of an inlet to a consumer unit consuming degassed liquid or a conduit leading to the inlet, a drive unit configured for circulating the liquid in the circulation path, and a filter in the circulation path for filtering particles or debris out of the liquid, wherein the liquid is forced through the filter by the drive unit. The drive unit includes a movable body, in particular a movable piston or a movable membrane, configured for at least partially degassing the liquid by generating a negative pressure in the liquid.

First claim

The invention claimed is:

1. A system for at least partially degassing a liquid, the system comprising:
a consumer unit configured to consume degassed liquid, wherein the degassed liquid is at least a portion of the liquid that has been at least partially degassed; and
a degasser, comprising:
a circulation path along which the liquid can be circulated between a liquid accommodation volume and one of an inlet to the consumer unit or a conduit leading to the inlet, the circulation path comprising a splitting point located upstream of or at the inlet of the consumer unit,
wherein the degasser is configured to split the at least partially degassed liquid at the splitting point to thereby form a first partial flow of the at least partially degassed liquid out of the degasser and into the consumer unit and a second partial flow of the at least partially degassed liquid back to the liquid accommodation volume; and
a drive unit configured for circulating the liquid in the circulation path,
wherein the drive unit comprises a movable body configured to at least partially degas the liquid by generating a negative pressure in the liquid.

2. The system according to claim 1 , comprising at least one of the following features:
the consumer unit is located vertically higher than the liquid accommodation volume;
the degasser is configured so that vapor originating from the liquid remains within the system;
the degasser is configured so that vapor originating from the liquid is completely returned into the liquid accommodation volume;
an inlet and an outlet of the circulation path in the liquid accommodation volume are located at the same height level.

3. The system according to claim 1 , wherein the circulation path is configured so that components of the liquid removed from the liquid are circulated back to the liquid accommodation volume.

4. The system according to claim 1 , wherein:
the consumer unit is configured to consume only part of the degassed liquid; and
the drive unit is configured to circulate another part of the degassed liquid, which is not consumed by the consumer unit, back to the liquid accommodation volume.

5. A sample separation device for separating a fluidic sample, the sample separation device comprising:
a pump for driving a mobile phase;
a sample separation unit for separating the fluidic sample in the mobile phase; and
the system according to claim 1 , wherein:
the consumer unit comprises the pump;
the pump is configured to drive the mobile phase, and the fluidic sample when injected in the mobile phase, toward the sample separation unit; and
the at least partially degassed liquid is supplied for creation of the mobile phase.

6. The sample separation device according to claim 5 , further comprising at least one of the following features:
at least part of the drive unit forms at least part of the pump;
at least part of the consumer unit forms at least part of the pump;
the sample separation device is configured as a chromatography sample separation device;
the sample separation device comprises a detector configured to detect separated fractions of the fluidic sample;
the sample separation device comprises a fractioner unit configured to collect separated fractions of the fluidic sample;
the sample separation device comprises an injector configured to inject the fluidic sample in the mobile phase.

7. The system according to claim 1 , comprising a chamber defining the liquid accommodation volume, wherein the movable body moves in the chamber.

8. The system according to claim 7 , comprising at least one of the following features:
the degasser has a gap between the movable body and the chamber for supplying the liquid to the chamber via the gap;
the movable body in the chamber forms part of one selected from the group consisting of: a piston pump; a syringe pump; and a membrane pump.

9. The system according to claim 1 , comprising a liquid container separate from the liquid accommodation volume, wherein the drive unit is configured to circulate the liquid between the consumer unit, the liquid container and the liquid accommodation volume.

10. The system according to claim 9 , wherein the degasser is configured to direct the second partial flow to the liquid container.

11. The system according to the claim 10 , comprising a gas separator at the splitting point, wherein the gas separator is configured to provide degassed liquid to the consumer unit and separated gas to the liquid container.

12. The system according to claim 9 , comprising a chamber defining the liquid accommodation volume, wherein the movable body moves in the chamber.

13. The system according to claim 1 , wherein the consumer unit is configured to consume the degassed liquid by transporting at least a portion of the degassed liquid to a destination separate from the circulation path.

14. The system according to claim 13 , wherein the destination comprises a sample separation unit, and the consumer unit is configured to transport the at least portion of the degassed liquid as a pressurized mobile phase to the sample separation unit.

15. The system according to claim 1 , wherein the consumer unit comprises a pump.

16. The system according to claim 1 , comprising a filter in the circulation path for filtering particles or debris out of the liquid, wherein the liquid is forced through the filter by the drive unit.

17. The system according to claim 1 , comprising an inlet restrictor positioned in the circulation path upstream of the drive unit, wherein the inlet restrictor is configured to contribute to the generating of the negative pressure.

18. A method for at least partially degassing a liquid, the method comprising:
circulating the liquid in a circulation path between a liquid accommodation volume and an inlet to a consumer unit consuming degassed liquid or a conduit leading to the inlet to the consumer unit;
at least partially degassing the liquid by generating a negative pressure in the liquid, by operating a movable body of a drive unit; and
splitting the at least partially degassed liquid at a splitting point located in the circulation path upstream of or at the inlet of the consumer unit, to thereby form a first partial flow of the at least partially degassed liquid out of the degasser and into the consumer unit and a second partial flow of the at least partially degassed liquid back to the liquid accommodation volume.

19. A sample separation device for separating a fluidic sample, the sample separation device comprising:
a pump for driving a mobile phase;
a sample separation unit for separating the fluidic sample in the mobile phase; and
a system for at least partially degassing a liquid, the system comprising:
a consumer unit configured to consume degassed liquid, wherein the degassed liquid is at least a portion of the liquid that has been at least partially degassed; and
a degasser, comprising:
a circulation path along which the liquid can be circulated between a liquid accommodation volume and one of an inlet to the consumer unit or a conduit leading to the inlet, the circulation path comprising a splitting point located upstream of or at the inlet of the consumer unit,
wherein the degasser is configured to split the at least partially degassed liquid at the splitting point to thereby form a first partial flow of the at least partially degassed liquid out of the degasser and into the consumer unit and a second partial flow of the at least partially degassed liquid back to the liquid accommodation volume; and

Assignees

• Agilent Technologies Inc

Inventors

• Shoykhet Konstantin

Classifications

• B01D19/0031 Primary

  by filtration · CPC title

• G01N30/10

  using a splitter · CPC title

• G01N30/14

  by elimination of some components · CPC title

• G01N30/6091

  Cartridges · CPC title

• G01N2030/027

  Liquid chromatography · CPC title