Chamber for transplantation and device for transplantation

Patent metadata

Field	Value
Publication number	US-11771806-B2
Application number	US-201916727817-A
Country	US
Kind code	B2
Filing date	Dec 26, 2019
Priority date	Jun 29, 2017
Publication date	Oct 3, 2023
Grant date	Oct 3, 2023

Abstract

According to the present invention, there are provided a chamber for transplantation, including a membrane for immunoisolation including a porous membrane at at least part of a boundary between an inside and an outside of the chamber for transplantation, in which the porous membrane contains a polymer and has a layered compact portion where a pore diameter is the smallest within the membrane, a pore diameter continuously increases in a thickness direction from the compact portion toward both one surface A and the other surface B of the porous membrane, a porosity in a vicinity of the surface A is 65% or more, an average pore diameter of the surface A is larger than an average pore diameter of the surface B, and the surface B is disposed on the inside of the chamber for transplantation; and a device for transplantation including the chamber for transplantation enclosing a biological constituent therein. In the chamber for transplantation of the present invention, angiogenesis in a recipient is induced and a deterioration in substance permeability is unlikely to occur.

First claim

What is claimed is:

1. A chamber for transplantation, comprising:
a membrane for immunoisolation at at least part of a boundary between an inside and an outside of the chamber for transplantation,
wherein the membrane for immunoisolation includes a porous membrane,
the porous membrane contains a polymer,
the porous membrane is formed from a single composition as a single layer and has a layered compact portion where a pore diameter is the smallest within the membrane,
a pore diameter continuously increases in a thickness direction from a compact portion toward both one surface A and the other surface B of the porous membrane,
a porosity in a vicinity of the surface A is 65% or more,
an average pore diameter of the surface A is larger than an average pore diameter of the surface B, and
the surface B is disposed on the inside of the chamber for transplantation.

2. The chamber for transplantation according to claim 1 , wherein an average pore diameter of the compact portion is 0.02 μm to 1.5 μm.

3. The chamber for transplantation according to claim 1 , wherein the average pore diameter of the surface A is 1.0 μm to 100 μm.

4. The chamber for transplantation according to claim 1 , wherein the average pore diameter of the surface B is 0.1 μm to 10 μm.

5. The chamber for transplantation according to claim 1 , wherein the average pore diameter of the surface A is three times or more the average pore diameter of the surface B.

6. The chamber for transplantation according to claim 1 , wherein a thickness of the compact portion is 0.5 μm to 30 μm.

7. The chamber for transplantation according to claim 1 , wherein a thickness of the porous membrane is 10 μm to 50 μm.

8. The chamber for transplantation according to claim 1 , wherein the porous membrane contains polysulfone or polyethersulfone, and at least one kind of hydrophilic polymers.

9. A device for transplantation, comprising the chamber for transplantation according to claim 1 enclosing a biological constituent therein.

10. The device for transplantation according to claim 9 , wherein the biological constituent releases a physiologically active substance.

11. The device for transplantation according to claim 10 , wherein the physiologically active substance is insulin.

12. A method for transplanting a biological constituent into a recipient, comprising enclosing a biological constituent in the chamber for transplantation according to claim 1 .

13. The method according to claim 12 , wherein the biological constituent releases a physiologically active substance.

14. The method according to claim 13 , wherein the physiologically active substance is insulin.

15. The method according to claim 12 , wherein the biological constituent is insulin-secreting cells.

16. A method for preventing an immune rejection by a recipient in a case of transplantation, comprising enclosing a biological constituent in the chamber for transplantation according to claim 1 .

17. The method according to claim 16 , wherein the biological constituent releases a physiologically active substance.

18. The method according to claim 17 , wherein the physiologically active substance is insulin.

19. A method for manufacturing a chamber for transplantation, using a membrane for immunoisolation,
wherein the membrane for immunoisolation includes a porous membrane,
the porous membrane contains a polymer,
the porous membrane is formed from a single composition as a single layer and has a layered compact portion where a pore diameter is the smallest within the membrane,
a pore diameter continuously increases in a thickness direction from the compact portion toward both one surface A and the other surface B of the porous membrane,
a porosity in a vicinity of the surface A is 65% or more,
an average pore diameter of the surface A is larger than an average pore diameter of the surface B.

20. The method according to claim 19 , comprising
providing the membrane for immunoisolation at at least part of a boundary between an inside and an outside of the chamber for transplantation, disposing the surface B on the inside of the chamber for transplantation.

Assignees

• Fujifilm Corp

Inventors

• Hasegawa Kazuhiro
• Takegami Ryuta
• Kaminaga Kuniyuki
• Mochizuki Yusuke

Classifications

• A01N1/146

  Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving · CPC title

• A01N1/128

  Chemically defined matrices for immobilising, holding or storing living parts, e.g. alginate gels; Chemically altering living parts, e.g. by cross-linking · CPC title

• A61L27/56 Primary

  Porous materials, {e.g. foams or sponges} · CPC title

• A01N1/0231

  Human Necessities · mapped topic

• A01N1/0263

  Human Necessities · mapped topic