Refined chlorogenic acid-containing composition manufacturing method

Patent metadata

Field	Value
Publication number	US-11771670-B2
Application number	US-201716345194-A
Country	US
Kind code	B2
Filing date	Sep 28, 2017
Priority date	Oct 26, 2016
Publication date	Oct 3, 2023
Grant date	Oct 3, 2023

Abstract

Provided is a method of producing a purified chlorogenic acid-containing composition, including a contact step of bringing a chlorogenic acid-containing composition having solids concentration of from 1.5 mass % to 4.7 mass % and a “caffeine/chlorogenic acid” mass ratio of 5 or less into contact with a porous adsorbent.

First claim

The invention claimed is:

1. A method of producing a purified chlorogenic acid-containing composition, comprising:
providing a chlorogenic acid-containing composition comprising chlorogenic acid and caffeine, wherein the chlorogenic acid-containing composition has a solids concentration of from 1.5 mass % to 4.7 mass % and a mass ratio of caffeine to chlorogenic acid is from 0.001 to 0.4; and
contacting the chlorogenic acid-containing composition with a porous adsorbent at a temperature of from 50° C. to 100° C.;
wherein the change ratio of caffeine to chlorogenic acid before and after purification is 89% or more, wherein the change ratio of caffeine to chlorogenic acid (%)=100−(C/D)/(E/F)×100, wherein C represents the mass of caffeine after contact with the porous adsorbent, D represents the mass of the chlorogenic acid after contact with the porous adsorbent, E represents the mass of caffeine before contact with the porous adsorbent, and F represents the mass of the chlorogenic acid before contact with the porous adsorbent.

2. The method of producing a purified chlorogenic acid-containing composition according to claim 1 , wherein the porous adsorbent comprises activated carbon.

3. The method of producing a purified chlorogenic acid-containing composition according to claim 2 , wherein a pore radius of the activated carbon is from 0.1 nm to 1.0 nm.

4. The method of producing a purified chlorogenic acid-containing composition according to claim 2 , wherein an average particle size of the activated carbon is from 0.01 mm to 2.0 mm.

5. The method of producing a purified chlorogenic acid-containing composition according to claim 1 , wherein the method of contacting the chlorogenic acid-containing composition with the porous adsorbent is a continuous method.

6. The method of producing a purified chlorogenic acid-containing composition according to claim 1 , wherein the porous adsorbent is used in an amount from 50 mass % to 400 mass % with respect to the solids concentration of the chlorogenic acid-containing composition.

7. The method of producing a purified chlorogenic acid-containing composition according to claim 1 , further comprising a step of subjecting a solution treated with the porous adsorbent to solid-liquid separation after the contact with the porous adsorbent.

8. The method of producing a purified chlorogenic acid-containing composition according to claim 7 , wherein the solid-liquid separation comprises one or two or more selected from the group consisting of paper filtration, centrifugal separation and membrane filtration.

9. The method of producing a purified chlorogenic acid-containing composition according to claim 1 , further comprising, before the contact step, a step of obtaining the chlorogenic acid-containing composition having solids concentration of from 1.5 mass % to 4.7 mass % and a mass ratio of caffeine to chlorogenic acid is from 0.001 to 0.4 through a step comprising an extraction step of subjecting at least one selected from the group consisting of green coffee beans, decaffeinated green coffee beans, roasted coffee beans having an L value of 30 or more, and decaffeinated roasted coffee beans having an L value of 25 or more, to column extraction using an aqueous solvent.

10. The method of producing a purified chlorogenic acid-containing composition according to claim 9 , wherein an extraction temperature in the extraction step is from 75° C. to 98° C.

11. The method of producing a purified chlorogenic acid-containing composition according to claim 9 , wherein the aqueous solvent comprises water.

12. The method of producing a purified chlorogenic acid-containing composition according to claim 1 , wherein the chlorogenic acid is selectively recovered.

13. The method of producing a purified chlorogenic acid-containing composition according to claim 12 , wherein caffeine is removed through a porous adsorbent treatment.

14. The method of producing a purified chlorogenic acid-containing composition according to claim 1 , wherein a value of G×H/I is >1.3, wherein G represents a mass of the recovered solution, H represents the solids concentration (mass %) of the chlorogenic acid-containing composition before contact with the porous adsorbent, and I represents the mass (g) of the porous adsorbent used.

15. The method of producing a purified chlorogenic acid-containing composition according to claim 1 , wherein the porous adsorbent is used in an amount from 80 mass % to 370 mass % with respect to the solids concentration of the chlorogenic acid-containing composition.

16. The method of producing a purified chlorogenic acid-containing composition according to claim 1 , wherein the porous adsorbent is used in an amount from 150 mass % to 350 mass % with respect to the solids concentration of the chlorogenic acid-containing composition.

Assignees

• Kao Corp

Inventors

• Hotta Yusuke
• Sugiyama Yukiteru

Classifications

• A61K36/742

  Coffea, e.g. coffee · CPC title

• A61K31/194 Primary

  having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid · CPC title

• A23F5/00

  Coffee; Coffee substitutes; Preparations thereof (preservation of coffee or coffee substitutes A23B90/00) · CPC title

• A23L33/105

  Plant extracts, their artificial duplicates or their derivatives · CPC title

• A61K31/216

  of acids having aromatic rings, e.g. benactizyne, clofibrate · CPC title