Device for interacting with neurological tissue and methods of making and using the same

Patent metadata

Field	Value
Publication number	US-11766560-B2
Application number	US-202016899820-A
Country	US
Kind code	B2
Filing date	Jun 12, 2020
Priority date	Apr 1, 2010
Publication date	Sep 26, 2023
Grant date	Sep 26, 2023

Abstract

Described herein are microelectrode array devices, and methods of fabrication, assembly and use of the same, to provide highly localized neural recording and/or neural stimulation to a neurological target. The device includes multiple microelectrode elements arranged protruding shafts. The protruding shafts are enclosed within an elongated probe shaft, and can be expanded from their enclosure. The microelectrode elements, and elongated probe shafts, are dimensioned in order to target small volumes of neurons located within the nervous system, such as in the deep brain region. Beneficially, the probe can be used to quickly identify the location of a neurological target, and remain implanted for long-term monitoring and/or stimulation.

First claim

What is claimed is:

1. A probe to find neurological targets, comprising:
an elongated shaft having a distal end and an internal lumen;
a shaft support at least partially disposed in the internal lumen, the shaft support comprising a plurality of shafts and a cylindrical member;
a microelectrode array film disposed on the cylindrical member, the microelectrode array film comprising a plurality of microelectrode film shafts, each of the plurality of microelectrode film shafts disposed on a corresponding shaft of the plurality of shafts and having at least one of a plurality of microelectrode elements, at least one of the plurality of microelectrode film shafts coupled with at least a portion of a neurological target;
a microelectronic component disposed along a portion of the microelectrode array film, the microelectronic component electrically coupled with one or more of the plurality of microelectrode elements, the microelectronic component having a signal generator to generate, based on a command signal, a signal to communicate via at least one of the plurality of microelectrode elements to measure or stimulate at least a portion of the neurological target and
the microelectronic component having a switch, the switch having a plurality of filters, each filter of the plurality of filters coupled between the switch and a corresponding microelectrode element of the plurality of microelectrode elements, each filter of the plurality of filters to tune the signal.

2. The probe of claim 1 , comprising the switch to select, from the plurality of microelectrode elements, a microelectrode element to which to convey the signal.

3. The probe of claim 1 , comprising the microelectronic component having an amplifier coupled between at least one of the plurality of microelectrode elements and an output of the microelectronic component to condition the signal.

4. The probe of claim 1 , comprising the microelectronic component having an encoder to transmit the signal measured from the portion of the neurological target from at least one of the plurality of microelectrode elements.

5. The probe of claim 1 , comprising the switch to select the signal to communicate with at least one of the plurality of microelectrode elements in accordance with one of a recording state or a stimulation state.

6. The probe of claim 1 , comprising the microelectronic component to convey the signal including an oscillating current to perform electrical impedance tomography between a first microelectrode element and a second microelectrode element on a microelectrode shaft of the plurality of microelectrode film shafts.

7. The probe of claim 1 , comprising a helical ribbon cable coupled with the microelectrode array film to permit movement of the plurality of microelectrode film shafts.

8. The probe of claim 1 , comprising the microelectronic component having:
the signal generator to generate the signal to measure at least the portion of the neurological target and to generate a second signal to stimulate at least the portion of the neurological target;
the switch electrically coupled with the signal generator, the switch to select one of the signal or the second signal in accordance with one of a recording state or a stimulation state.

9. The probe of claim 1 , comprising the microelectronic component having:
the signal generator to increase a field potential of the signal and to induce a spike in the signal to output a second signal; and
the switch electrically to select one of the signal and the second signal, based on a second command signal, to convey to one or more of the plurality of microelectrode elements via the switch.

10. The probe of claim 1 , comprising the microelectronic component disposed on a microelectronic platform corresponding to a portion of the microelectrode array film.

11. A method of finding neurological targets, comprising:
implanting a neurological probe within a vicinity of a neurological target, the neurological probe comprising:
an elongated shaft having a distal end and an internal lumen;
a shaft support at least partially disposed in the internal lumen, the shaft support comprising a plurality of shafts and a cylindrical member;
a microelectrode array film disposed on the cylindrical member, the microelectrode array film comprising a plurality of microelectrode film shafts, each of the plurality of microelectrode film shafts disposed on a corresponding shaft of the plurality of shafts and having at least one of a plurality of microelectrode elements, at least one of the plurality of microelectrode film shafts coupled with at least a portion of the neurological target; and
a microelectronic component disposed along a portion of the microelectrode array film, the microelectronic component electrically coupled with one or more of the plurality of microelectrode elements, the microelectronic component having a signal generator to generate, based on a command signal, a signal to communicate via at least one of the plurality of microelectrode elements;

the microelectronic component having a switch, the switch having a plurality of filters, each filter of the plurality of filters coupled between the switch and a corresponding microelectrode element of the plurality of microelectrode elements, each filter of the plurality of filters to tune the signal; and
providing the command signal to the signal generator of the microelectronic component to generate the signal to communicate via at least one of the plurality of microelectrode elements to measure or stimulate at least a portion of the neurological target.

12. The method of claim 11 , comprising implanting the neurological probe, the microelectronic component of the neurological probe having the switch to select, from the plurality of microelectrode elements, a microelectrode element to which to convey the signal.

13. The method of claim 11 , comprising implanting the neurological probe, the microelectronic component of the neurological probe having an amplifier coupled between at least one of the plurality of microelectrode elements and an output of the microelectronic component to condition the signal.

14. The method of claim 11 , comprising implanting the neurological probe, the microelectronic component of the neurological probe having an encoder to transmit the signal measured from the portion of the neurological target from at least one of the plurality of microelectrode elements.

15. The method of claim 11 , comprising implanting the neurological probe, the microelectronic component of the neurological probe having the switch to select the signal to communicate with at least one of the plurality of microelectrode elements in accordance with one of a recording state or a stimulation state.

16. The method of claim 11 , comprising providing an oscillating current to perform electrical impedance tomography between a first microelectrode element and a second microelectrode element on a microelectrode shaft of the plurality of microelectrode film shafts.

Assignees

• Ecole Polytechnique Fed Lausanne Epfl

Inventors

• Mercanzini André
• Renaud Philippe
• Pollo Claudio

Classifications

• A61N1/0534 Primary

  Electrodes for deep brain stimulation · CPC title

• A61B5/0536

  Impedance imaging, e.g. by tomography · CPC title

• A61B5/24

  Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof · CPC title

• A61B5/4041

  Evaluating nerves condition · CPC title

• A61B5/4893

  Nerves · CPC title