Systems and methods for performing multiple precurser, neutral loss and product ion scans in a single ion trap
US-2019035614-A1 · Jan 31, 2019 · US
Precursor and neutral loss scan in an ion trap
US11764046B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11764046-B2 |
| Application number | US-202217730830-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 27, 2022 |
| Priority date | Nov 2, 2015 |
| Publication date | Sep 19, 2023 |
| Grant date | Sep 19, 2023 |
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Abstract
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The invention generally relates to systems and methods for precursor and neutral loss scan in an ion trap. In certain aspects, the invention provides a system that includes a mass spectrometer having an ion trap, and a central processing unit (CPU). The CPU includes storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to excite a precursor ion and eject a product ion in the single ion trap.
First claim
Opening claim text (preview).
What is claimed is: 1. A system comprising: a mass spectrometer comprising a single rectilinear ion trap; and a central processing unit (CPU), and storage coupled to the CPU and storing instructions that when executed by the CPU cause the system to apply to the single ion trap a constant alternating current (AC) frequency and ramping a radio frequency (RF) voltage in a reverse direction in order to excite a precursor ion and eject a product ion in the single ion trap, wherein the excitation of the precursor ion occurs through application of at least two signals to the single ion trap and the ejection of the product ion occurs through simultaneous application of a third signal to the ion trap, and wherein a second detector of a mass spectrometer is positioned orthogonal to a first detector of the mass spectrometer such that ions made unstable by the second AC signal and are ejected from the ion trap and received at the second detector. 2. The system according to claim 1 , wherein the third signal comprises a variable frequency that results in ejection of the corresponding product ion from the ion trap. 3. The system according to claim 1 , wherein the product ion has a neutral loss and the third signal is configured to scan a frequency of the product ion at a constant mass offset from the precursor ion that corresponds to the neutral loss.
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Classifications
- H01J49/0081Primary
Tandem in time, i.e. using a single spectrometer · CPC title
Three-dimensional ion traps, i.e. comprising end-cap and ring electrodes · CPC title
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- What does patent US11764046B2 cover?
- The invention generally relates to systems and methods for precursor and neutral loss scan in an ion trap. In certain aspects, the invention provides a system that includes a mass spectrometer having an ion trap, and a central processing unit (CPU). The CPU includes storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to excite a precursor ion and e…
- Who is the assignee on this patent?
- Purdue Research Foundation
- What technology area does this patent fall under?
- Primary CPC classification H01J49/0081. Mapped technology areas include Electricity.
- When was this patent published?
- Publication date Tue Sep 19 2023 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 12 related publications on this page (citations in our corpus or others sharing the same primary CPC).